| 1. |
- Brodin, Petter, et al.
(författare)
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Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice
- 2010
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 5:10, s. e13174-
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Tidskriftsartikel (refereegranskat)abstract
- Background: A major group of murine inhibitory receptors on Natural Killer (NK) cells belong to the Ly49 receptor family and recognize MHC class I molecules. Infected or transformed target cells frequently downmodulate MHC class I molecules and can thus avoid CD8(+) T cell attack, but may at the same time develop NK cell sensitivity, due to failure to express inhibitory ligands for Ly49 receptors. The extent of MHC class I downregulation needed on normal cells to trigger NK cell effector functions is not known. Methodology/Principal Findings: In this study, we show that cells expressing MHC class I to levels well below half of the host level are tolerated in an in vivo assay in mice. Hemizygous expression (expression from only one allele) of MHC class I was sufficient to induce Ly49 receptor downmodulation on NK cells to a similar degree as homozygous expression, despite a strongly reduced cell surface level of MHC class I. Co-expression of weaker MHC class I ligands in the host did not have any further effect on the degree of Ly49 downmodulation. Furthermore, a single MHC class I allele could downmodulate up to three Ly49 receptors on individual NK cells. Only when NK cells simultaneously expressed several Ly49 receptors and hemizygous MHC class I levels, a putative threshold for Ly49 downmodulation was reached. Conclusion: Collectively, our findings suggest that in interactions between NK cells and normal untransformed cells, MHC class I molecules are in most cases expressed in excess compared to what is functionally needed to ensure self tolerance and to induce maximal Ly49 downmodulation. We speculate that the reason for this is to maintain a safety margin for otherwise normal, autologous cells over a range of MHC class I expression levels, in order to ensure robustness in NK cell tolerance.
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| 2. |
- Abrahamsen, Rune, et al.
(författare)
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Dynamic Response of Tall Timber Buildings Under Service Load : The DynaTTB Research Program
- 2020
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Ingår i: EURODYN 2020, XI international conferece on structural dynamics. - : National Technical University of Athens. - 9786188507210 ; , s. 4900-4910
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Konferensbidrag (refereegranskat)abstract
- Wind-induced dynamic excitation is becoming a governing design action determin-ing size and shape of modern Tall Timber Buildings (TTBs). The wind actions generate dynamic loading, causing discomfort or annoyance for occupants due to the perceived horizontal sway – i.e. vibration serviceability failure. Although some TTBs have been instrumented and meas-ured to estimate their key dynamic properties (natural frequencies and damping), no systematic evaluation of dynamic performance pertinent to wind loading has been performed for the new and evolving construction technology used in TTBs. The DynaTTB project, funded by the Forest Value research program, mixes on site measurements on existing buildings excited by heavy shakers, for identification of the structural system, with laboratory identification of building elements mechanical features coupled with numerical modelling of timber structures. The goal is to identify and quantify the causes of vibration energy dissipation in modern TTBs and pro-vide key elements to FE modelers.The first building, from a list of 8, was modelled and tested at full scale in December 2019. Some results are presented in this paper. Four other buildings will be modelled and tested in spring 2020.
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| 3. |
- Abrahamsen, Rune, et al.
(författare)
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Dynamic response of tall timber buildings under service load : results from the dynattb research program
- 2023
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Ingår i: World Conference on Timber Engineering 2023 (WCTE 2023). - : Curran Associates, Inc.. - 9781713873297 ; , s. 2907-2914
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Konferensbidrag (refereegranskat)abstract
- Wind-induced dynamic excitation is a governing design action determining size and shape of modern Tall Timber Buildings (TTBs). The wind actions generate dynamic loading, causing discomfort or annoyance for occupants due to the perceived horizontal sway, i.e. vibration serviceability problem. Although some TTBs have been instrumented and measured to estimate their key dynamic properties (eigenfrequencies, mode shapes and damping), no systematic evaluation of dynamic performance pertinent to wind loading had been performed for the new and evolving construction technologies used in TTBs. The DynaTTB project, funded by the ForestValue research program, mixed on site measurements on existing buildings excited by mass inertia shakers (forced vibration) and/or the wind loads (ambient vibration), for identification of the structural system, with laboratory identification of building elements mechanical features, coupled with numerical modelling of timber structures. The goal is to identify and quantify the causes of vibration energy dissipation in modern TTBs and provide key elements to finite element models. This paper presents an overview of the results of the project and the proposed Guidelines for design of TTBs in relation to their dynamic properties.
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| 4. |
- Bengtsson, Johan, et al.
(författare)
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Closed-loop Combustion Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics
- 2004
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Ingår i: International Journal of Adaptive Control and Signal Processing. - : Wiley. - 0890-6327 .- 1099-1115. ; 18:2, s. 167-179
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Tidskriftsartikel (refereegranskat)abstract
- Homogeneous charge compression ignition (HCCI) is a hybrid of the sparkignition and compression ignition engine concepts. As in a sparkignition engine, a homogeneous fuel-air mixture is created in theinlet system. During the compression stroke the temperature of themixture increases and reaches the point of auto ignition, just as in acompression ignition engine (or Diesel). One challenge with HCCI engines isthe need for good timing control of the combustion. Auto ignition of ahomogeneous mixture is very sensitive to operating condition. Evensmall variations of the load can change the timing from too early totoo late combustion. Thus a fast combustion timing control isnecessary since it sets the performance limitation of the loadcontrol. As measurement for combustion timing feedback, the crank angleof 50% burnt has been used. This paper performs a comparative studyof different cylinder-pressure based methods for estimating the crankangle of 50% burnt. The estimates are compared in terms of accuracy,robustness and feasibility for cycle-to-cycle real-time control.Dynamic models of CA50 are estimated using system identification asa means to find models relevant to engine control.
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| 5. |
- Bengtsson, Johan, et al.
(författare)
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Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics
- 2004
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Ingår i: Proceedings of the 2004 American Control Conference, ACC : June 30 - July 2, 2004, Boston Sheraton Hotel, Boston, Massachusetts. - 0743-1619. - 0780383354 ; 5, s. 4048-4053
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Konferensbidrag (refereegranskat)abstract
- The Homogeneous Charge Compression Ignition (HCCI) combustionconcept lacks direct ignition timing control, instead the autoignition depends on the operating condition. Since auto ignition of ahomogeneous mixture is very sensitive to operating conditions, a fastcombustion timing control is necessary for reliable operation. Hence,feedback is needed and the crank angle of 50% burnt (CA50) has provedto be a reliable feedback indicator of on-going combustion inpractice. CA50 or other methods for detecting on-going cylinderpressure used in the feedback control of a HCCI engine all rely onpressure sensors. This paper presents a newcandidate for control of HCCI engine by using the electronicconductive properties in the reaction zone. This phenomenon is calledion current. This paper perform combustion timing control based on ioncurrent and compare it with control based on pressure sensor. Thecombustion timing control is performed on cycle-to-cycle basis and the engine is a one-cylinder version of a heavy duty engine equipped with a port injection system using dual fuels.
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| 6. |
- Bengtsson, Johan, et al.
(författare)
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Hybrid Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics
- 2006
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Ingår i: International Journal of Control. - : Informa UK Limited. - 0020-7179 .- 1366-5820. ; 79:5, s. 422-448
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Tidskriftsartikel (refereegranskat)abstract
- The homogeneous charge compression ignition ( HCCI) combustion engine principle lacks direct ignition timing control, instead the auto-ignition depends on the operating condition. Since auto-ignition of a homogeneous mixture is very sensitive to operating conditions, fast combustion phasing control is necessary for reliable operation. For this paper, a six-cylinder heavy-duty HCCI engine was controlled on a cycle-to-cycle basis in real time. Sensors, actuators and control structures for control of the HCCI combustion were compared. Among several actuators for HCCI engine control suggested, two actuators were compared-i.e., dual-fuel actuation and variable valve actuation (VVA). As for control principles, model predictive control (MPC) has several desirable features and today MPC can be applied to relatively fast systems, such as VVA and dual-fuel actuation. For sensor feedback control of the HCCI engine, cylinder pressure and ion current - i.e., the electronic conductive properties in the reaction zone - were compared. Combustion phasing control based on ion current was compared to control based on cylinder pressure. For the purpose of control synthesis requiring dynamic models, system identification provided models of the HCCI combustion, the models being validated by stochastic model validation. With such models providing a basis for model-based control, MPC control results were compared to PID and LQG control results. While satisfying the constraints on cylinder pressure, both control of the combustion phasing and control of load torque was achieved with simultaneous minimization of the fuel consumption and emissions.
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| 7. |
- Bengtsson, Johan, et al.
(författare)
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Model Predictive Control of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics
- 2006
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Ingår i: 2006 IEEE Conference on Computer Aided Control System Design, 2006 IEEE International Conference on Control Applications, 2006 IEEE International Symposium on Intelligent Control. ; , s. 1675-1680
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Konferensbidrag (refereegranskat)abstract
- The Homogeneous Charge Compression Ignition ({HCCI}) combustion principle lacks direct ignition timing control, instead the auto-ignition depends on the operating condition and fast combustion phasing control is necessary for reliable operation. A six-cylinder heavy-duty HCCI engine was controlled on a cycle-to-cycle basis in real time using a variety of sensors, actuators and control structures for control of the {HCCI} combustion in comparison. Combustion phasing control based on ion current was compared to feedback control based on cylinder pressure. Two actuators were compared, dual fuel and Variable Valve Actuation (VVA). Model-based control synthesis requiring dynamic models of low complexity and HCCI combustion models were estimated by system identification and by physical modeling. The models identified by system identification were used to design model-predictive control (MPC) with several desirable features and today applicable to relatively fast systems. Both control of the combustion phasing and control of load-torque with simultaneous minimization of the fuel consumption and emissions were included.
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| 8. |
- Bengtsson, Johan, et al.
(författare)
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Multi-Output Control of a Heavy Duty HCCI Engine Using Variable Valve Actuation and Model Predictive Control
- 2006
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Ingår i: 2006 SAE World Congress. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International.
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Konferensbidrag (refereegranskat)abstract
- Autoignition of a homogeneous mixture is very sensitive to operating conditions, therefore fast control is necessary for reliable operation. There exists several means to control the combustion phasing of an Homogeneous Charge Compression Ignition (HCCI) engine, but most of the presented controlled HCCI result has been performed with single-input single-output controllers. In order to fully operate an HCCI engine several output variables need to be controlled simultaneously, for example, load, combustion phasing, cylinder pressure and emissions. As these output variables have an effect on each other, the controller should be of a structure which includes the cross-couplings between the output variables. A Model Predictive Control (MPC) controller is proposed as a solution to the problem of load-torque control with simultaneous minimization of the fuel consumption and emissions, while satisfying the constraints on cylinder pressure. One of the major motivations for using MPC is that it explicitly takes the constraints into account. When operating an HCCI engine there are several contraints present, for example on the cylinder pressure and on the emissions. A drawback of MPC is the potentially large on-line computational effort, which has historically limited its application to relative slow and/or small applications. Today, MPC can be applied in relative fast systems, and we will demonstrate that it can be used for control of HCCI engine dynamics on a cycle-to-cycle basis. As feedback signal of the combustion phasing, the crank angle for 50% burned, based on cylinder pressure, is used. In the control design of the MPC controllers (one for each cylinder), dynamic models obtained by system identification were used. This paper presents cycle-to-cycle cylinder individual control results from a six-cylinder HCCI engine using a Variable Valve Actuation (VVA) system and MPC controllers.
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| 9. |
- Bengtsson, Johan, et al.
(författare)
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System Identification of Homogenous Charge Compression Ignition (HCCI) Engine Dynamics
- 2004
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Ingår i: Advances in Automotive Control. - 0080442501 ; 37:22, s. 37-37
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Konferensbidrag (refereegranskat)abstract
- Homogeneous Charge Compression Ignition (HCCI) combustion lacksdirect ignition timing control, instead the auto ignition depends on the operatingcondition. Since auto ignition of a homogeneous mixture is very sensitive tooperating condition a fast combustion timing control is necessary for reliableoperation, the ignition timing control design requiring appropriate modelsand system output variables for its feedback design. This paper demonstratesthe use of system modeling and identification as a means to find modelsrelevant to the engine control. The identification methods used were varioussubspace-based methods. An LQG controller was designed based on the estimatedmodels and tested on a six-cylinder heavy duty engine running in HCCI operation.
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| 10. |
- Ekholm, Kent, et al.
(författare)
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Ethanol-Diesel Fumigation in a Multi-Cylinder Engine
- 2008
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Ingår i: SAE technical paper 2008-01-0033.
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Konferensbidrag (refereegranskat)abstract
- Fumigation was studied in a 12 L six-cylinder heavy-duty engine. Port-injected ethanol was ignited with a small amount of diesel injected into the cylinder. The setup left much freedom for influencing the combustion process, and the aim of this study was to find operation modes that result in a combustion resembling that of a homogeneous charge compression ignition (HCCI) engine with high efficiency and low NOx emissions. Igniting the ethanol-air mixture using direct-injected diesel has attractive properties compared to traditional HCCI operation where the ethanol is ignited by pressure alone. No preheating of the mixture is required, and the amount of diesel injected can be used to control the heat release rate. The two fuel injection systems provide a larger flexibility in extending the HCCI operating range to low and high loads. It was shown that cylinder-to-cylinder variations present a considerable challenge for this type of combustion. By using closed-loop cylinder-individual control based on incylinder pressure sensors, combustion was successfully harmonized between the cylinders. Successful fumigation operation was verified up to 18.4 bar BMEP at a fixed engine speed of 1450 rpm. Two load points (4.6 bar BMEP and 9.2 bar BMEP) were studied in detail. Different diesel injection timings, diesel ratios, and EGR rates were investigated, and comparisons were drawn to pure diesel operation of the same engine. At medium load (9.2 bar BMEP), it was possible to obtain a stable HCCI-like combustion with low NOx emissions (0.1 g/kWh), reasonably high brake efficiency (37 %), and low pressure derivatives (5 bar/CAD). High load operation (18.4 bar BMEP) resulted in low pressure derivatives (5.5 bar/CAD), acceptable brake efficency (36 %), and relatively low NOx emissions (0.34 g/kWh).
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