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- Haas, Rüdiger, 1966, et al.
(författare)
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Status of the Onsala Twin Telescopes – Two Years After the Inauguration
- 2019
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Ingår i: Proceedings of the 24th European VLBI Group for Geodesy and Astrometry Working Meeting. - 9788441656345 ; , s. 5-9
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Konferensbidrag (refereegranskat)abstract
- We give a brief overview on the status of the Onsala twin telescopes (OTT), two years after their inauguration. The dierent components of the VGOS systems are briefly described, and the development towards routine operations.
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| 5. |
- Haas, Rüdiger, 1966, et al.
(författare)
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Status of the Onsala Twin Telescopes – One Year After the Inauguration
- 2019
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Ingår i: IVS 2018 General Meeting Proceedings "Global Geodesy and the Role of VGOS – Fundamental to Sustainable Development". ; NASA/CP-2019-219039, s. 17-19
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Konferensbidrag (refereegranskat)abstract
- We briefly describe the status of the Onsala twin telescopes and the experience gained since the official inauguration in May 2017.
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| 6. |
- Herbert, Roger, 1966-, et al.
(författare)
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Bakgrundshalter av metaller i Svenska inlands- och kustvatten.
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- I tillämpningen av Vattendirektivet i Sverige kommer miljökvalitetsnormer att sättas både för prioriterade och andra ämnen enligt ett dotterdirektiv till Vattendirektivet. Hänsyn kommer att tas till bakgrundshalterna av de ämnen som förekommer naturligt, och det är därför av stor betydelse att fastställa sådana bakgrundshalter. Syftet med denna studie är att utifrån befintliga data ta fram bakgrundshalter för metaller i svenska sjöar, vattendrag, kustvatten och hav. Termen bakgrundshalt i denna studie syftar på en regional bakgrundshalt som är typiskt för vatten som är opåverkat av punktutsläpp eller försurning, men kan ha påverkats av depositionen av förbränningsrester från fossila och andra bränslen samt av diffusa utsläpp från jord- och skogsbruk. Regionala bakgrundshalter kan anses vara nutida bakgrundshalter, och gäller för en viss region och/eller vattentyp.Bakgrundshalter för metaller i vattendrag och sjöar fastställdes efter inventering och kvalitetssäkring av mätdata samt inventering av punktutsläppskällor. Bakgrundshalter för metaller i kustvatten och hav fastställdes efter en enklare kvalitetssäkring. I enlighet med Naturvårdsverkets indelningskriterier för limniska typer redovisas bakgrundshalter för metaller i vattendrag och sjöar för alla sju limniska ekoregioner i Sverige, med ytterligare indelningar baserade på hydromorfologiska egenskaper (humus- och kalkhalt). Bakgrundshalten av en metall i en viss limnisk ekoregion och klass beräknades som 50-percentilen (medianvärdet) av medianhalten för varje stationer inom samma klassning.Efter kvalitetsgranskning och jämförelsen med MIFO-objekt (dvs punktutsläppskällor) reducerades den ursprungliga databasen med 613 vattendragsstationer och 454 sjöstationer till 453 respektive 444 stationer. Efter ytterligare granskning användes slutligen mätdata från 430 vattendragsstationer och 438 sjöstationer för bestämning av bakgrundshalter. För beräkning av bakgrundshalter i kust- och havsvatten användes 245 mätpunkter, varav 49 i kustzonen och resten i öppet hav.Resultaten från bestämningen av bakgrundshalter i sjöar visar att humushalt och kalkhalt (och därmed pH) har generellt sett stor inverkan på metallhalterna. De högsta bakgrundshalterna av metaller sammanfaller ofta med sura sjöar. Kalkfattiga humusrika sjöar har i allmänhet högre bakgrundshalter av Fe än kalkfattiga humusfattiga sjöar, vilket tyder på ett samband mellan humus- och järnhalt. Vissa metaller såsom Co, Cr och V visar samvariation med Fe i dessa humusrika kalkfattiga sjöar. En jämförelse med de tidigare regionala bakgrundshalterna för sjöar i norra och södra Sverige visar att många av de nyräknade bakgrundshalterna ligger högre än de tidigare halterna.Analyserna visar relativt stora skillnader i metallhalter mellan vattendrag i norra och södra Sverige. Medianhalter i norra Sverige ligger mer än 50% lägre än halterna i södra Sverige, vilket kan förklaras främst med mindre luftdeposition i norra Sverige. Relativt höga regionala bakgrundshalter för Cr, Cu och Ni har beräknats för kalkrika vattendrag i sydöstra Sverige (ekoregion 4), där vissa vattendrag kan beskrivas som slättlandsåar. Beräknade bakgrundshalter av metaller i kustvatten och havsvatten visar att det finns stor variabilitet i främst Mn- och Zn-halter, där skillnaden mellan 25:e- och 75:e-percentilen uppgår till mer än en tiopotens. En jämförelse av halter mellan filtrerade och ofiltrerade prover från Egentliga Östersjön tyder på att en stor andel av de undersökta metallerna i ofiltrerat havsvatten är partikelbundna. Detta kan förklara den stora variabiliten i främst Mn- och Zn-, men också i Cd-, Co-, Fe- och Hg-halter.För att i framtiden kunna beräkna bakgrundshalter för kustområden, Västerhavet och Bottenhavet samt för att få en bättre bild av halterna i Egentliga Östersjön behövs omfattande provtagningar och analyser med enhetliga metoder.
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| 7. |
- Jansson, John-Olov, 1954, et al.
(författare)
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Body weight homeostat that regulates fat mass independently of leptin in rats and mice.
- 2018
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 115:2, s. 427-432
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Tidskriftsartikel (refereegranskat)abstract
- Subjects spending much time sitting have increased risk of obesity but the mechanism for the antiobesity effect of standing is unknown. We hypothesized that there is a homeostatic regulation of body weight. We demonstrate that increased loading of rodents, achieved using capsules with different weights implanted in the abdomen or s.c. on the back, reversibly decreases the biological body weight via reduced food intake. Importantly, loading relieves diet-induced obesity and improves glucose tolerance. The identified homeostat for body weight regulates body fat mass independently of fat-derived leptin, revealing two independent negative feedback systems for fat mass regulation. It is known that osteocytes can sense changes in bone strain. In this study, the body weight-reducing effect of increased loading was lost in mice depleted of osteocytes. We propose that increased body weight activates a sensor dependent on osteocytes of the weight-bearing bones. This induces an afferent signal, which reduces body weight. These findings demonstrate a leptin-independent body weight homeostat ("gravitostat") that regulates fat mass.
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| 8. |
- Johansson, I, et al.
(författare)
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PD-1 inhibitor therapy of basal cell carcinoma with pulmonary metastasis. : PD-1 inhibition in basal cell carcinoma
- 2022
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Ingår i: Journal of the European Academy of Dermatology and Venereology. - : Wiley. - 1468-3083 .- 0926-9959. ; 36:Suppl 1, s. 70-73
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Tidskriftsartikel (refereegranskat)abstract
- Basal cell carcinoma (BCC) may be challenging to differentiate from basaloid squamous cell carcinoma (bSCC), both clinically and histologically. BCC constitutes one of the most common tumours and metastatic behaviour is extremely rare. In contrast, bSCC is a rare entity with an increased propensity for distant metastasis. If these conditions develop into inoperable metastatic disease, the therapeutic alternatives are different, but the use of PD-1 inhibitors may be a valid option for both. Here, we report a case with complex histology with a component initially classified as bSCC with lung metastases and treated with the PD-1 inhibitor cemiplimab resulting in radiological and clinical responses. Re-examination of the lung biopsy using routine histomorphology in combination with immunohistochemical staining for cytokeratin 14, cytokeratin17 and BerEp4 has, however, revealed a histopathological pattern of BCC, which is in concordance with a similar analysis of the cutaneous primary tumour in the face that the patient underwent surgery for more than 5years earlier.
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| 9. |
- Johansson, Roger, 1966-, et al.
(författare)
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Assessing Flexibility : The Frequency and Horizon Approach
- 2001
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper focuses on flexibility in the area of flexible automatic assembly systems. Far-reaching research has been done in effort to develop flexible automatic assembly systems. A dilemma that appears in understanding the focus for these research projects is the immense amounts of flexibility concepts used. This paper proposes a structure for the concepts based on frequency and horizon for different events in an assembly system. The results are presented in a proposed “flexibility map”. Based on the “frequency and horizon approach” and the definition of flexibility as “the penalty of change” [1], an argumentation concerning what kind of flexibility is most valuable in an assembly system can be discussed. The paper also points out the demands for a flexibility that allows for de-coupling of high and low frequency events in a system. A clear distinction is made between dynamic flexibility and static flexibility. It is a well-known fact that the increase of the dynamic flexibility in an assembly system will decrease the static flexibility [2]. The paper ends with a proposal for decreasing the negative correlation between dynamic- and static flexibility. An objective for further research concerning whether a certain process within an assembly system affects certain flexibility is also presented.
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| 10. |
- Johansson, Roger, 1966-
(författare)
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Implementation of Flexible Automatic Assembly in Small Companies : Flexibility and Process demands
- 2002
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis has its focus within Flexible Automatic Assembly (FAA) systems and its implementation in small companies. The small companies are an important part of a country’s industry and economy. The need for the small company to increase the technology level, in order to be competitive in a global market as a supplier, is evident. The prevailing competence and economical resources of most small companies are often limited, a fact which underlines the need for economical, technological and application flexibility for their assembly system solutions. Therefore, these needs could be viewed as the main objectives posed on solutions which claim to be flexible, such as FAA systems.The objectives for this thesis are:- to investigate the state-of-the-art in FAA systems; the primary focus of the investigation residing upon flexibility issues. Theoretical study.- to investigate the implementation process in a small company that tries to apply FAA technology, and observe the problems that must be solved. Empirical study.- propose an approach as to how FAA systems should be structured.As a prerequisite for the proposed structure, the state of the art within FAA systems is discussed with focus on flexibility. The work in this thesis is based on the hypothesis that if systems are developed with properties satisfying the SME needs, the FAA-systems would be user-friendlier both in an economical- and a competence perspective. Hence the need to evaluate the status of current FAA systems.The work attempts to illustrate, through the theoretical and empirical studies, that there are three main factors that limit success when implementing FAA systems in small companies: Competence acquisition, Product design and Strategy for implementation. Learning, or competence acquisition, is most often carried out in parallel with the actual use of the system. This extensive learning phase most often leads to the system becoming obsolete during its expected run-time (period of use). The product design is another area of interest as it often seems hard to motivate product changes to facilitate automatic assembly, especially if no system is at hand as a driving force. The work also showed that there is a lack of strategy for implementation of FAA. The understanding of the FAA system impact on the product development and manufacturing is not understood, thus, the implementation is treated as a local phenomenon in the assembly shop. Furthermore, the ii uncertainty concerning future development of products is reflected in short payoff times, which makes the economical justification of systems difficult.All of these factors have been misrepresented to date due to a loose application of the term flexibility, and its implications. Therefore, the work attempts to clarify the flexibility issues, in terms of the assembly process demands, and also proposes a new flexibility map.To facilitate implementation of FAA into small companies, a modular assembly system approach is proposed. The modules should be task oriented. By using a modular approach, the possibility to have a system that is easy to keep up to date with product development, is greatly improved and the risk to invest in dead ends will decrease. Furthermore, it should become simpler to find an optimal level of automation or to prioritise the flexibility efforts, and thereby reduce the cost for maintaining flexibility over the system lifespan.A way to develop a decision.making tool for prioritising the flexibility efforts is proposed by using a Penalty-of-Change curve, which exploits the proposed flexibility map as a base. The modular approach is a way to decrease the negative correlation between dynamic flexibility (on-line) and static flexibility (off-line), since too much dynamic flexibility otherwise tends to limit the possibility to change the system to new situations. The modular approach isolates this negative correlation within modules. The technological adaptability will increase if a modular system is used since the standardised interfaces between modules define clear borders between functions or tasks within a system. Furthermore, a modular approach facilitates stepwise knowledge acquisition since it will be natural to focus on modules instead of entire systems.A leading idea in this thesis is, that small and large companies have the same system demands at module level, which makes it possible to increase the market for standardised modules and thereby decrease the cost for such modules. In other words, standardised modules, instead of systems. Modular systems are not optimised in terms of a low cost/capacity ratio for a certain product generation, instead, the system is optimised towards, reconfigurability to be able to follow product evolution, or totally rebuild for new products. Which, in the long run, may lead to a low cost/capacity ratio. Therefore, a prerequisite for the use of modular systems is that the systems will operate in a frequently changing market where fast ramp-up are more important (to maintain the market share) than an optimised system for each product generation.
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