| 1. |
- Demmelmaier, Ingrid, 1960-, et al.
(författare)
-
Does exercise intensity matter for fatigue during (neo-)adjuvant cancer treatment? The Phys-Can randomized clinical trial
- 2021
-
Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 31:5, s. 1144-1159
-
Tidskriftsartikel (refereegranskat)abstract
- Exercise during cancer treatment improves cancer-related fatigue (CRF), but the importance of exercise intensity for CRF is unclear. We compared the effects of high- vs low-to-moderate-intensity exercise with or without additional behavior change support (BCS) on CRF in patients undergoing (neo-)adjuvant cancer treatment. This was a multicenter, 2x2 factorial design randomized controlled trial (Clinical Trials NCT02473003) in Sweden. Participants recently diagnosed with breast (n = 457), prostate (n = 97) or colorectal (n = 23) cancer undergoing (neo-)adjuvant treatment were randomized to high intensity (n = 144), low-to-moderate intensity (n = 144), high intensity with BCS (n = 144) or low-to-moderate intensity with BCS (n = 145). The 6-month exercise intervention included supervised resistance training and home-based endurance training. CRF was assessed by Multidimensional Fatigue Inventory (MFI, five subscales score range 4-20), and Functional Assessment of Chronic Illness Therapy-Fatigue scale (FACIT-F, score range 0-52). Multiple linear regression for main factorial effects was performed according to intention-to-treat, with post-intervention CRF as primary endpoint. Overall, 577 participants (mean age 58.7 years) were randomized. Participants randomized to high- vs low-to-moderate-intensity exercise had lower physical fatigue (MFI Physical Fatigue subscale; mean difference −1.05 [95% CI: −1.85, −0.25]), but the difference was not clinically important (ie <2). We found no differences in other CRF dimensions and no effect of additional BCS. There were few minor adverse events. For CRF, patients undergoing (neo-)adjuvant treatment for breast, prostate or colorectal cancer can safely exercise at high- or low-to-moderate intensity, according to their own preferences. Additional BCS does not provide extra benefit for CRF in supervised, well-controlled exercise interventions.
|
|
| 2. |
- Gad, Helge, et al.
(författare)
-
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
- 2014
-
Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 508:7495, s. 215-221
-
Tidskriftsartikel (refereegranskat)abstract
- Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, we show that cancer cells require MTH1 activity to avoid incorporation of oxidized dNTPs, resulting in DNA damage and cell death. We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and selectively engage and inhibit the MTH1 protein in cells. Protein co-crystal structures demonstrate that the inhibitors bindin the active site of MTH1. The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts. This study exemplifies the non-oncogene addiction concept for anticancer treatment and validates MTH1 as being cancer phenotypic lethal.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Andersson, Ronnie, 1975, et al.
(författare)
-
EP2819891 B1
- 2016
-
Patent (övrigt vetenskapligt/konstnärligt)
|
|
| 7. |
- Berntsen, Sveinung, et al.
(författare)
-
Design of a randomized controlled trial of physical training and cancer (Phys-Can) - the impact of exercise intensity on cancer related fatigue, quality of life and disease outcome
- 2017
-
Ingår i: BMC Cancer. - : Springer Science and Business Media LLC. - 1471-2407. ; 17:1, s. 1-12
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Cancer-related fatigue is a common problem in persons with cancer, influencing health-related quality of life and causing a considerable challenge to society. Current evidence supports the beneficial effects of physical exercise in reducing fatigue, but the results across studies are not consistent, especially in terms of exercise intensity. It is also unclear whether use of behaviour change techniques can further increase exercise adherence and maintain physical activity behaviour. This study will investigate whether exercise intensity affects fatigue and health related quality of life in persons undergoing adjuvant cancer treatment. In addition, to examine effects of exercise intensity on mood disturbance, adherence to oncological treatment, adverse effects from treatment, activities of daily living after treatment completion and return to work, and behaviour change techniques effect on exercise adherence. We will also investigate whether exercise intensity influences inflammatory markers and cytokines, and whether gene expressions following training serve as mediators for the effects of exercise on fatigue and health related quality of life. Methods/design: Six hundred newly diagnosed persons with breast, colorectal or prostate cancer undergoing adjuvant therapy will be randomized in a 2 × 2 factorial design to following conditions; A) individually tailored low-to-moderate intensity exercise with or without behaviour change techniques or B) individually tailored high intensity exercise with or without behaviour change techniques. The training consists of both resistance and endurance exercise sessions under the guidance of trained coaches. The primary outcomes, fatigue and health related quality of life, are measured by self-reports. Secondary outcomes include fitness, mood disturbance, adherence to the cancer treatment, adverse effects, return to activities of daily living after completed treatment, return to work as well as inflammatory markers, cytokines and gene expression. Discussion: The study will contribute to our understanding of the value of exercise and exercise intensity in reducing fatigue and improving health related quality of life and, potentially, clinical outcomes. The value of behaviour change techniques in terms of adherence to and maintenance of physical exercise behaviour in persons with cancer will be evaluated. Trial registration:NCT02473003 , October, 2014.
|
|
| 8. |
- Boström, Henrik, et al.
(författare)
-
On Evidential Combination Rules for Ensemble Classifiers
- 2008
-
Ingår i: Proceedings of the 11th International Conference on Information Fusion. - : IEEE. - 9783800730926 - 9783000248832 ; , s. 553-560
-
Konferensbidrag (refereegranskat)abstract
- Ensemble classifiers are known to generally perform better than each individual classifier of which they consist. One approach to classifier fusion is to apply Shafer’s theory of evidence. While most approaches have adopted Dempster’s rule of combination, a multitude of combination rules have been proposed. A number of combination rules as well as two voting rules are compared when used in conjunction with a specific kind of ensemble classifier, known as random forests, w.r.t. accuracy, area under ROC curve and Brier score on 27 datasets. The empirical evaluation shows that the choice of combination rule can have a significant impact on the performance for a single dataset, but in general the evidential combination rules do not perform better than the voting rules for this particular ensemble design. Furthermore, among the evidential rules, the associative ones appear to have better performance than the non-associative.
|
|
| 9. |
- Boström, Henrik, et al.
(författare)
-
On the Definition of Information Fusion as a Field of Research
- 2007
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A more precise definition of the field of information fusion can be of benefit to researchers within the field, who may use uch a definition when motivating their own work and evaluating the contribution of others. Moreover, it can enable researchers and practitioners outside the field to more easily relate their own work to the field and more easily understand the scope of the techniques and methods developed in the field. Previous definitions of information fusion are reviewed from that perspective, including definitions of data and sensor fusion, and their appropriateness as definitions for the entire research field are discussed. Based on strengths and weaknesses of existing definitions, a novel definition is proposed, which is argued to effectively fulfill the requirements that can be put on a definition of information fusion as a field of research.
|
|
| 10. |
- Brax, Christoffer, et al.
(författare)
-
Evaluating Precise and Imprecise State-Based Anomaly Detectors for Maritime Surveillance
- 2010
-
Ingår i: Proceedings of the 13th International Conference on Information Fusion. - : IEEE. - 9780982443811 ; , s. Article number 5711997-
-
Konferensbidrag (refereegranskat)abstract
- We extend the State-Based Anomaly Detection approach by introducing precise and imprecise anomaly detectors using the Bayesian and credal combination operators, where evidences over time are combined into a joint evidence. We use imprecision in order to represent the sensitivity of the classification regarding an object being normal or anomalous. We evaluate the detectors on a real-world maritime dataset containing recorded AIS data and show that the anomaly detectors outperform previously proposed detectors based on Gaussian mixture models and kernel density estimators. We also show that our introduced anomaly detectors perform slightly better than the State-Based Anomaly Detection approach with a sliding window.
|
|
