| 1. |
- Ahrné, Karin, et al.
(författare)
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Rödlista över fjärilar Lepidoptera
- 2015
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Ingår i: Rödlistade arter i Sverige 2015. - Uppsala : ArtDatabanken SLU. - 9789187853104 ; , s. 98-112
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Jakobson Mo, Susanna, et al.
(författare)
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Dopamine transporter imaging with [18F]FE-PE2I PET and [123I]FP-CIT SPECT – a clinical comparison
- 2018
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Ingår i: EJNMMI Research. - : Springer. - 2191-219X. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Background: Dopamine transporter (DAT) imaging may be of diagnostic value in patients with clinically suspected parkinsonian disease. The purpose of this study was to compare the diagnostic performance of DAT imaging with positron emission computed tomography (PET), using the recently developed, highly DAT-selective radiopharmaceutical [18F]FE-PE2I (FE-PE2I), to the commercially available and frequently used method with [123I]FP-CIT (FP-CIT) single-photon emission computed tomography (SPECT) in early-stage idiopathic parkinsonian syndrome (PS).Methods: Twenty-two patients with a clinical de novo diagnosis of PS and 28 healthy controls (HC) participating in an on-going clinical trial of FE-PE2I were analyzed in this study. Within the trial protocol, participants are clinically reassessed 2 years after inclusion. A commercially available software was used for automatic calculation of FP-CIT-specific uptake ratio (SUR). MRI-based volumes of interest combined with threshold PET segmentation were used for FE-PE2I binding potential relative to non-displaceable binding (BPND) quantification and specific uptake value ratios (SUVR).Results: PET with FE-PE2I revealed significant differences between patients with a clinical de novo diagnosis of PS and healthy controls in striatal DAT availability (p < 0.001), with excellent accuracy of predicting dopaminergic deficit in early-stage PS. The effect sizes were calculated for FE-PE2I BPND (Glass’s Δ = 2.95), FE-PE2I SUVR (Glass’s Δ = 2.57), and FP-CIT SUR (Glass’s Δ = 2.29). The intraclass correlation (ICC) between FE-PE2I BPND FP-CIT SUR was high in the caudate (ICC = 0.923), putamen (ICC = 0.922), and striatum (ICC = 0.946), p < 0.001. Five of the 22 patients displayed preserved striatal DAT availability in the striatum with both methods. At follow-up, a non-PS clinical diagnosis was confirmed in three of these, while one was clinically diagnosed with corticobasal syndrome. In these patients, FE-PE2I binding was also normal in the substantia nigra (SN), while significantly reduced in the remaining patients. FE-PE2I measurement of the mean DAT availability in the putamen was strongly correlated with BPND in the SN (R = 0.816, p < 0.001). Olfaction and mean putamen DAT availability was correlated using both FE-PE2I BPND and FP-CIT SUR (R ≥ 0.616, p < 0.001).Conclusion: DAT imaging with FE-PE2I PET yields excellent basic diagnostic differentiation in early-stage PS, at least as good as FP-CIT SPECT.
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| 3. |
- Rafnar, Thorunn, et al.
(författare)
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European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
- 2011
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Ingår i: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 20:21, s. 4268-81
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Tidskriftsartikel (refereegranskat)abstract
- Three genome-wide association studies in Europe and the USA have reported eight urinary bladder cancer (UBC) susceptibility loci. Using extended case and control series and 1000 Genomes imputations of 5 340 737 single-nucleotide polymorphisms (SNPs), we searched for additional loci in the European GWAS. The discovery sample set consisted of 1631 cases and 3822 controls from the Netherlands and 603 cases and 37 781 controls from Iceland. For follow-up, we used 3790 cases and 7507 controls from 13 sample sets of European and Iranian ancestry. Based on the discovery analysis, we followed up signals in the urea transporter (UT) gene SLC14A. The strongest signal at this locus was represented by a SNP in intron 3, rs17674580, that reached genome-wide significance in the overall analysis of the discovery and follow-up groups: odds ratio = 1.17, P = 7.6 × 10(-11). SLC14A1 codes for UTs that define the Kidd blood group and are crucial for the maintenance of a constant urea concentration gradient in the renal medulla and, through this, the kidney's ability to concentrate urine. It is speculated that rs17674580, or other sequence variants in LD with it, indirectly modifies UBC risk by affecting urine production. If confirmed, this would support the 'urogenous contact hypothesis' that urine production and voiding frequency modify the risk of UBC.
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| 4. |
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| 5. |
- af Geijerstam, Peder, Doktorand, 1983-, et al.
(författare)
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P-selectin and C-reactive protein in relation to home blood pressure and coronary calcification: a SCAPIS substudy
- 2024
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Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598.
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Tidskriftsartikel (refereegranskat)abstract
- Background: Soluble P-selectin (sP-selectin) and high-sensitivity C-reactive protein (hsCRP) have previously been associated with hypertension, but the relation with out-of-office blood pressure (BP) and coronary artery calcification score is unknown. We aimed to examine the relationship between sP-selectin, hsCRP and home BP, as well as coronary artery calcification score and carotid artery plaques.Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS), 5057 randomly selected participants were evaluated with office and home BP using the semi-automatic Omron M10-IT device. For this cross-sectional study, participants with sP-selectin <4 standard deviations above mean and hsCRP <5 mg/l, representing low-grade inflammation, were included. Using generalized linear models, these inflammatory markers were evaluated in relation to BP classifications, as well as coronary artery calcification score and carotid artery plaques.Results: Of participants, 4548 were included in the analyses. The median age was 57.2 (53.4–61.2) years, and 775 (17.0%) reported taking medication for hypertension. Participants in the highest quartile of sP-selectin [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.40–1.98, P < 0.001] and hsCRP [OR 2.25, (95% CI 1.89–2.60), P < 0.001] were more likely to have sustained hypertension. Participants in the highest quartile of hsCRP were also more likely to have masked hypertension, OR (95% CI) 2.31 (1.72–3.10), P < 0.001 and carotid artery plaques, OR (95% CI) 1.21 (1.05–1.38), P = 0.007.Conclusion: Increased sP-selectin and hsCRP were independently associated with sustained hypertension. These findings indicate an association between hypertension and platelet activity, as expressed by sP-selectin.
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| 6. |
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| 7. |
- Al-Gburi, Majid, et al.
(författare)
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Effect of casting sequences on the restraint in slab-on-ground
- 2014
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Konferensbidrag (refereegranskat)abstract
- One of the widespread issues in concrete structures is cracks occurring at early age. Cracks that appear in the young concrete may cause early start of corrosion of rebars or early penetration of harmful liquids or gases into the concrete body. These situations could result in reduced service life and in significantly increased maintenance cost of structures. Therefore it is important for construction companies to avoid these cracks. Restraint represents one of the main sources of thermal and shrinkage stresses at early age concrete. The casting sequence is affected by the restraint from adjacent structures. The present study discusses the influence of five casting sequences for the typical structure slab-on-ground. The aim is to map restraints for a number of possible casting sequences, and to identify the sequence with the lowest restraint. The study covers both continuous and jumped casting sequences, which include one, two and three contact edges. The result shows that the best casting sequence is the continuous technique with one contact edge.
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| 8. |
- Al-Gburi, Majid, et al.
(författare)
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Effect of the boundary conditions on the crack distribution in early age concrete
- 2014
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Ingår i: Nordic Concrete Research. - 0800-6377. ; 50, s. 347-351
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Tidskriftsartikel (refereegranskat)abstract
- Restrained movement in early age concrete may cause cracking. The boundary conditions – restraint – influence the possible crack distribution. This study aims at highlighting the effect of such restraint on the crack distribution. This is done by using the “Cracking Model for Concrete” in ABAQUS/Explicit simulating the non-linear behaviour under and after cracking. In the study the typical case wall-on-slab was in focus using a structure previously been tested in laboratory with both fixed and free bottom slab. The result of the modelling shows fairly good agreement with the cracks observed in the tests.
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| 9. |
- Al-Gburi, Majid, et al.
(författare)
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Prediction of Restraint in Second Cast Sections of Concrete Culverts using Artificial Neural Networks
- 2018
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Ingår i: European Journal of Environmental and Civil Engineering. - : Taylor & Francis. - 1964-8189 .- 2116-7214. ; 22:2, s. 226-245
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Tidskriftsartikel (refereegranskat)abstract
- Estimation of restraint is very important for accurately predicting the risk of early thermal and shrinkage cracking in concrete structures. The stress in young concrete is affected by changes in its dimensions during hydration and the restraint imposed by adjoining structures. In concrete culverts, the restraints from existing structures acting upon the first and second casting sections to be cast are different, causing them to exhibit different early cracking behaviour. This work presents a new method for predicting restraint in complex concrete structures using artificial neural networks (ANNs). Finite element calculations were performed to predict restraint in 108 slabs, 324 walls and 972 roofs from second sections of concrete culverts, and the results obtained were used to train and validate ANN models. The ANN models were then used to study the effects of varying selected parameters (the thickness and width of the roof and slab, the thickness and height of the walls, and the length of the culvert section) on the predicted restraint. Mathematical expressions for predicting restraint values in slabs, walls and roofs were derived based on the ANN models’ output and implemented in an Excel spreadsheet that provides a simple way of predicting restraint in practical applications. Restraint values predicted in this way agree well with the results of finite-element calculations
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| 10. |
- Al-Gburi, Majid, et al.
(författare)
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Reducing Thermal Crack Risks Caused by Restraint in Young Concrete - A Case Study on Walls of Water Tanks
- 2022
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Ingår i: Nordic Concrete Research. - : Walter de Gruyter. - 0800-6377 .- 2545-2819. ; 66:1, s. 41-54
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Tidskriftsartikel (refereegranskat)abstract
- Concrete cracks in structures such as water tanks and nuclear power stations cause anxiety to owners, contractors and engineers. These cracks may significantly increase the structure’s permeability and thus increase leakage, reduce durability, and eventually lead to loss of structural functionality. Therefore it is important to minimize their occurrence and size. To identify effective ways of minimizing cracking in young concrete segments, a parametric study was conducted using the finite element method (FEM). Parameters considered include casting sequence, joint position, wall height, and cooling. The study examined continuous and jumped casting approaches to the casting of a cylindrical reinforced concrete tank for a sewage-treatment plant, with and without the application of the ‘kicker’ technique in which the lower part of the wall is cast with the slab. The main cause of cracking is thermal change and restraint imposed by adjacent older structures, and the FEM predictions agree well with experimental observations. Continuous casting is most effective at minimizing cracking because it creates only two contact edges between newly cast and existing structures producing the lowest level of restraint. The kicker technique is shown to be very effective for reducing restraint and consider rephasing.
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