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- Jonasson, Grethe, 1945, et al.
(författare)
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Skeletal bone mineral density in relation to thickness, bone mass, and structure of the mandibular alveolar process in dentate men and women.
- 2007
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Ingår i: European journal of oral sciences. - : Wiley. - 0909-8836 .- 1600-0722. ; 115:2, s. 117-23
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Tidskriftsartikel (refereegranskat)abstract
- Peri-apical radiographs have been used to identify women with low bone mineral density (BMD) in various parts of the skeleton, but their usefulness for men has not been elucidated. The aim of this study was to test if the mandibular bone structure and bone mass in men and women were related to the BMD of the forearms, determined by dual X-ray absorptiometry, in 42 men and 42 women (aged 18-84 yr). Mandibular alveolar thickness was measured in casts, and alveolar 'bone mass' was estimated on digital radiographs using gray-shade distribution. Alveolar bone structure was evaluated visually (trabecular pattern) on analog radiographs and with its bone texture on digitized radiographs. Bone texture was correlated to BMD in both men and women. BMD was correlated to alveolar bone mass and trabecular pattern in women, but not in men. Bone texture and body mass index (BMI) explained 57% of the variance in BMD for men, whereas trabecular pattern and age explained 50% of the variance in BMD for women. Sparse trabeculation was associated with osteopenia. We conclude that alveolar bone texture and BMI are predictors of BMD for men, and age and trabecular pattern are predictors of BMD for women.
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| 4. |
- Berglund, Lisa, et al.
(författare)
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A whole-genome bioinformatics approach to selection of antigens for systematic antibody generation
- 2008
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Ingår i: Proteomics. - : Wiley. - 1615-9853 .- 1615-9861. ; 8:14, s. 2832-2839
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Tidskriftsartikel (refereegranskat)abstract
- Here, we present an antigen selection strategy based on a whole-genome bioinformatics approach, which is facilitated by an interactive visualization tool displaying protein features from both public resources and in-house generated data. The web-based bioinformatics platform has been designed for selection of multiple, non-overlapping recombinant protein epitope signature tags by display of predicted information relevant for antigens, including domain- and epitope sized sequence similarities to other proteins, transmembrane regions and signal peptides. The visualization tool also displays shared and exclusive protein regions for genes with multiple splice variants. A genome-wide analysis demonstrates that antigens for approximately 80% of the human protein-coding genes can be selected with this strategy.
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- Cornelissen, Johannes H C, et al.
(författare)
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Global negative vegetation feedback to climate warming responses of leaf litter decomposition rates in cold biomes
- 2007
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Ingår i: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 10:7, s. 619-627
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Tidskriftsartikel (refereegranskat)abstract
- Whether climate change will turn cold biomes from large long-term carbon sinks into sources is hotly debated because of the great potential for ecosystem-mediated feedbacks to global climate. Critical are the direction, magnitude and generality of climate responses of plant litter decomposition. Here, we present the first quantitative analysis of the major climate-change-related drivers of litter decomposition rates in cold northern biomes worldwide.Leaf litters collected from the predominant species in 33 global change manipulation experiments in circum-arctic-alpine ecosystems were incubated simultaneously in two contrasting arctic life zones. We demonstrate that longer-term, large-scale changes to leaf litter decomposition will be driven primarily by both direct warming effects and concomitant shifts in plant growth form composition, with a much smaller role for changes in litter quality within species. Specifically, the ongoing warming-induced expansion of shrubs with recalcitrant leaf litter across cold biomes would constitute a negative feedback to global warming. Depending on the strength of other (previously reported) positive feedbacks of shrub expansion on soil carbon turnover, this may partly counteract direct warming enhancement of litter decomposition.
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- Dolatabadi, Soheila, et al.
(författare)
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FUS-DDIT3 Fusion Oncoprotein Expression Affects JAK-STAT Signaling in Myxoid Liposarcoma
- 2022
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Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- Myxoid liposarcoma is one of the most common sarcoma entities characterized by FET fusion oncogenes. Despite a generally favorable prognosis of myxoid liposarcoma, chemotherapy resistance remains a clinical problem. This cancer stem cell property is associated with JAK-STAT signaling, but the link to the myxoid-liposarcoma-specific FET fusion oncogene FUS-DDIT3 is not known. Here, we show that ectopic expression of FUS-DDIT3 resulted in elevated levels of STAT3 and phosphorylated STAT3. RNA sequencing identified 126 genes that were regulated by both FUS-DDIT3 expression and JAK1/2 inhibition using ruxolitinib. Sixty-six of these genes were connected in a protein interaction network. Fifty-three and 29 of these genes were confirmed as FUS-DDIT3 and STAT3 targets, respectively, using public chromatin immunoprecipitation sequencing data sets. Enriched gene sets among the 126 regulated genes included processes related to cytokine signaling, adipocytokine signaling, and chromatin remodeling. We validated CD44 as a target gene of JAK1/2 inhibition and as a potential cancer stem cell marker in myxoid liposarcoma. Finally, we showed that FUS-DDIT3 interacted with phosphorylated STAT3 in association with subunits of the SWI/SNF chromatin remodeling complex and PRC2 repressive complex. Our data show that the function of FUS-DDIT3 is closely connected to JAK-STAT signaling. Detailed deciphering of molecular mechanisms behind tumor progression opens up new avenues for targeted therapies in sarcomas and leukemia characterized by FET fusion oncogenes.
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- Fagerberg, Linn, et al.
(författare)
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Prediction of the human membrane proteome
- 2010
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Ingår i: Proteomics. - : Wiley. - 1615-9853 .- 1615-9861. ; 10:6, s. 1141-1149
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Tidskriftsartikel (refereegranskat)abstract
- Membrane proteins are key molecules in the cell, and are important targets for pharmaceutical drugs. Few three-dimensional structures of membrane proteins have been obtained, which makes computational prediction of membrane proteins crucial for studies of these key molecules. Here, seven membrane protein topology prediction methods based on different underlying algorithms, such as hidden Markov models, neural networks and support vector machines, have been used for analysis of the protein sequences from the 21 416 annotated genes in the human genome. The number of genes coding for a protein with predicted cc-helical transmembrane region(s) ranged from 5508 to 7651, depending on the method used. Based on a majority decision method, we estimate 5539 human genes to code for membrane proteins, corresponding to approximately 26% of the human protein-coding genes. The largest fraction of these proteins has only one predicted transmembrane region, but there are also many proteins with seven predicted transmembrane regions, including the G-protein coupled receptors. A visualization tool displaying the topologies suggested by the eight prediction methods, for all predicted membrane proteins, is available on the public Human Protein Atlas portal (www.proteinatlas.org).
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- Jonasson, Julia, 1981-, et al.
(författare)
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Projektet TJAFS : Normkritisk Tjänsteutveckling i Avfallssystemet
- 2018
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Rapport (populärvet., debatt m.m.)abstract
- Sverige har ett av världens mest effektiva avfallssystem ur ett miljöperspektiv. Vi har mycket låg grad av deponi och förbränning och hög grad av källsortering. Men det har visat sig svårt att öka andelen sorterat avfall.Orsaken till bristande sorteringsgrad och nedskräpning sägs ofta vara att brukare inte förstår systemet eller att de medvetet slarvar i hanteringen av sitt avfall och vid sortering vid lokala återvinningsstationer.Men tänk om det inte stämmer. Tänk om det finns orsaker i designen av själva avfallssystemet som avgör brukarens benägenhet och möjlighet att göra rätt.I den här utförliga rapporten ges exempel på vad som händer när designmetoder, tjänstedesign, normkritik och stadsutveckling möts för att utmana det nuvarande avfallssystemet.
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| 9. |
- Jonasson, Julia, 1981-, et al.
(författare)
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Returcykeln : Ett normkreativt avfallsprojekt
- 2018
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Rapport (populärvet., debatt m.m.)abstract
- Sverige har ett av världens mest effektiva avfallssystem ur ett miljöperspektiv. Vi har mycket låg grad av deponi och förbränning och hög grad av källsortering. Men det har visat sig svårt att öka andelen sorterat avfall.Orsaken till bristande sorteringsgrad och nedskräpning sägs ofta vara att brukare inte förstår systemet eller att de medvetet slarvar i hanteringen av sitt avfall och vid sortering vid lokala återvinningsstationer.Men tänk om det inte stämmer. Tänk om det finns orsaker i designen av avfallssystemet som avgör brukarens benägenhet och möjlighet att göra rätt.I den här korta rapporten ges exempel på vad som händer när designmetoder, tjänstedesign, normkritik och stadsutveckling möts för att utmana det nuvarande avfallssystemet.
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| 10. |
- Jonasson, Kalle, et al.
(författare)
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The 6th HUPO Antibody Initiative (HAI) workshop : Sharing data about affinity reagents and other recent developments
- 2010
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Ingår i: Proteomics. - : Wiley. - 1615-9853 .- 1615-9861. ; 10:11, s. 2066-2068
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Tidskriftsartikel (refereegranskat)abstract
- The Human Antibody Initiative (HAI) aims to promote and facilitate the use of antibodies for proteomics research. The 6th workshop for the HUPO Antibody Initiative (HAI) held in September 2009 was co-chaired by Michael Snyder and Mathias Uhlen and discussed several aspects of antibody production, their validation, and attempts to standardise this process, in particular, when subsequently described in the literature. An update on the progress of the Human Protein Atlas was also presented to the attendees.
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