| 1. |
- Olsen, Rickard, 1979-, et al.
(författare)
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Flexible automation in the printing industry
- 2012
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Ingår i: Proceedings of the 5th International Swedish Production Symposium. - 9789175197524 ; , s. 45-51
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The printing industry had a turnaround on about 700 billion US dollar in 2008. Althoughthe printing process itself is highly automated, a lot of the handling between process stepsis done manually and these heavy lifts could result in occupational injuries with long timeexposure. Operators for example can lift up to 1-2 tons/hour when moving large stacks ofpaper from a pallet to a jogger table before cutting. For quality reasons it’s important tomake these lifts with correct airing of the paper and without harming the edges or surface,something a human is very adapt in doing. To see if it is possible to do this mechanically,a dual armed robot equipped with grippers was used to lift an air paper stacks inlaboratory experiments. In order to achieve the same high quality as in manual handlingthese experiments tested the grippers, gripper fingers, robot movements and grippositions to find the best parameters for a future automated paper handling cell. The testsshowed that a dual armed robot could lift paper stacks with satisfying airing withoutharming the paper. Also, better gripper fingers were developed for lifting the paper withouttears or surface marks.
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| 2. |
- Sepulveda, Jorge I. Ramirez, et al.
(författare)
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Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients
- 2017
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Ingår i: Biology of Sex Differences. - : BioMed Central. - 2042-6410. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Background: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjogren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS. Methods: Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers. The mean follow-up time (years) was 8.8 +/- 7.6 for women and 8.5 +/- 6.2 for men (ns). Clinical data including serological and hematological parameters and glandular and extraglandular manifestations were compared between men and women. Results: Male patient serology was characterized by more frequent positivity for anti-Ro/SSA and anti-La/SSB (p = 0. 02), and ANA (p = 0.02). Further, men with pSS were more frequently diagnosed with interstitial lung disease (p = 0. 008), lymphadenopathy (p = 0.04) and lymphoma (p = 0.007). Conversely, concomitant hypothyroidism was more common among female patients (p = 0.009). Conclusions: We observe enhanced serological responses and higher frequencies of lymphoma-related extraglandular manifestations in men with pSS. Notably, lymphoma itself was also significantly more common in men. These observations may reflect an aggravated immune activation and a more severe pathophysiological state in male patients with pSS and indicate a personalized managing of the disease due to the influence of the sex of patients with pSS.
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| 3. |
- Albert, Malin, et al.
(författare)
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Hospitalized patients’ attitudes towards participating in a randomized control trial in case of a cardiac arrest
- 2024
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Ingår i: Resuscitation Plus. - 2666-5204. ; 18
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundNo previous study has evaluated patients attitudes towards inclusion in an ongoing cardiac arrest clinical trial. The aim of this study was to assess patientś willingness and motives to participate in the ongoing randomized controlled drug trial “Vasopressin and Steroids in addition to Adrenaline in cardiac arrest” (VAST-A trial) in case of an in-hospital cardiac arrest (IHCA).ObjectivesHospitalized patients, men ≥ 18 and women ≥ 50 years, were asked for informed consent for inclusion in the VAST-A trial in case of an IHCA, the reason for approving or declining inclusion in the trial and baseline characteristics.MethodsPatients admitted to hospital were asked to give informed consent of inclusion in VAST-A in case of an IHCA during their hospital stay. Patients were also asked why they approved or declined inclusion as well as baseline characteristics questions.Results1,064 patients were asked about willingness to participate in the VAST-A trial, of these 902 (84.8%) patients approved inclusion. A subgroup of 411 patients were, except willingness, also asked about motives to participate or not and basic characteristics. The main reason for approving inclusion was to contribute to research (n = 328, 83.9%). The main reason for declining inclusion was concerns regarding testing the drug treatment (n = 6, 30%).ConclusionAmong hospitalized patients the vast majority gave informed consent to inclusion in an ongoing randomized cardiac arrest drug trial. The main reason for approving inclusion was to contribute to research.
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| 4. |
- Baran, M, et al.
(författare)
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SURVIVIN IS AN ESSENTIAL MEDIATOR OF ARTHRITIS INTERACTING WITH UROKINASE SIGNALLING.
- 2009
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Ingår i: Journal of cellular and molecular medicine. - : Wiley. - 1582-4934 .- 1582-1838. ; 13:9B, s. 3797-3808
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT Proto-oncogene survivin has recently been identified as a prognostic marker distinguishing patients with destructive rheumatoid arthritis (RA). In the present material of 132 RA patients and 82 controls the levels of survivin correlated to urokinase (uPA) (r=0.46), a plasminogen activator over expressed in inflamed joints and known to exhibit potent arthritogenic properties. Here we evaluate the functional relationship between these proteins using primary synovial fibroblasts and leukocytes of RA patients, human monocytic (THP-1) and fibroblast (MRC-5) cell lines. Using inhibitors of intracellular signalling we show that uPA and survivin share common transduction pathways being in synovial fibroblasts dependent on the activity of tyrosine kinases, PI3-kinase and MEK. Moreover, uPA production is significantly reduced in fibroblasts if survivin synthesis has been silenced by siRNA. Importantly, silencing of survivin in fibroblasts prevented their invasive growth in knee joints of SCID mice. Interaction of uPA with receptor up regulates survivin expression in leukocytes. In turn, survivin is required for the upregulation of uPA receptor on cell surface. These findings indicate that survivin is an essential mediator of arthritogenic properties of uPA regulating its synthesis in synovial fibroblasts and uPAR expression in leukocytes. Close correlation between survivin and uPA levels in patients with RA supports the importance of this connection for the pathogenesis of arthritis.
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| 5. |
- Björnsson, Andreas, 1981-, et al.
(författare)
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Automated material handling in composite manufacturing using pick-and-place systems - a review
- 2018
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Ingår i: Robotics and Computer-Integrated Manufacturing. - : Elsevier BV. - 0736-5845 .- 1879-2537. ; 51, s. 222-229
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Tidskriftsartikel (refereegranskat)abstract
- With increasing use of fiber reinforced polymer composites follows a natural pursuit for more rational and effective manufacturing. Robotic pick-and-place systems can be used to automate handling of a multitude of materials used in the manufacturing of composite parts. There are systems developed for automated layup of prepreg, dry fibers and thermoplastic blanks as well as to handle auxiliary materials used in manufacturing. The aim of this paper is to highlight the challenges associated with automated handling of these materials and to analyze the main design principles that have been employed for pick-and-place systems in terms of handling strategy, reconfigurability, gripping technology and distribution of gripping points etc. The review shows that it is hard to find generic solutions for automated material handling due to the great variety in material properties. Few cases of industrial applications in full-scale manufacturing could be identified.
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| 6. |
- Björnsson, Andreas, 1981-, et al.
(författare)
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Automation of composite manufacturing using off-the-shelf solutions; three cases from the aerospace industry
- 2015
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Ingår i: ICCM International Conferences on Composite Materials. - : International Committee on Composite Materials.
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Konferensbidrag (refereegranskat)abstract
- With an increased use of composite materials follows a need for rational, cost-efficient manufacturing processes. This paper explores how off-the-shelf solutions, developed for other purposes than composite manufacturing, can be used to build systems for automated composite manufacturing. Three demonstrators, each of them dealing with a specific type of material and all of them representing different manufacturing technologies for automated composite manufacturing, are presented and analyzed to find aspects that affect the ability to use off-the-shelf solutions. The three demonstrators target low to medium manufacturing volumes of complex products and they have been developed in collaboration with industrial partners within the aerospace industry. The conclusions drawn from the development of the demonstrators are that it is technically feasible to use off-the-shelf solutions in the three cases while adhering to the high quality standards of the industry. Furthermore three groups of aspects, quality aspects, product aspects and system aspects, which affect the ability to use off-the-shelf solutions for automated composite manufacturing, are identified.
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| 7. |
- Björnsson, Andreas, 1981-, et al.
(författare)
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Low-cost Automation for Prepreg Handling - Two Cases from the Aerospace Industry
- 2015
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Ingår i: SAE International Journal of Materials & Manufacturing. - Warrendale, USA : SAE International. - 1946-3979 .- 1946-3987. ; 9:1, s. 68-74
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Tidskriftsartikel (refereegranskat)abstract
- With an increased use of composite materials within the aerospace industry follows a need for rational and cost-effective methods for composite manufacturing. Manual operations are still common for low to medium manufacturing volumes and complex products. Manual operations can for example be found in material handling, when picking prepreg plies from a cutter table and stacking them to form a plane laminate in preparation for a subsequent forming operation. Stacking operations of this kind often involves a great number of different ply geometries and removal of backing paper and other protecting materials like plastic. In this paper two different demonstrator cells for automated picking of prepreg plies and stacking of plane laminates are presented. One demonstrator is utilizing a standard industrial robot and an advanced end-effector to handle the ply variants. The other demonstrator is using a dual arm robot which allow for simpler end-effector design. In combination with a previously developed system for automated removal of backing papers both systems have shown to be capable of automatically picking prepreg plies from a plane surface and stack them to generate a flat multistack laminate. The dual arm approach has shown advantageous since it result in simpler end-effector design and a successive lay down sequence that result in good adhesion between the plies in the laminate. null.
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| 8. |
- Björnsson, Andreas, 1981-, et al.
(författare)
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Robot-forming of prepreg stacks - Development of equipment and methods
- 2016
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Ingår i: ECCM 2016 - Proceeding of the 17th European Conference on Composite Materials. - : European Conference on Composite Materials, ECCM. - 9783000533877
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Konferensbidrag (refereegranskat)abstract
- Within the aerospace industry the manufacturing of composite components with complex shapes, such as spars, ribs and beams are often manufactured using manual layup and forming of prepreg material. Automated processes for prepreg layup and efficient forming techniques like vacuum forming are sometimes difficult to employ to these type of products due to technical limitations. This paper describes the development of tools and the forming sequence needed to automate sequential forming of a complex shape using an industrial robot. Plane prepreg stacks are formed to the final shape using a dual-arm industrial robot equipped with rolling tools. Tests show that the developed tools and the employed sequence can be used to form stacks to the desired shape with acceptable quality.
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| 9. |
- Boström, Elisabeth Almer, 1983, et al.
(författare)
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Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis.
- 2011
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Ingår i: Arthritis and rheumatism. - : Wiley. - 1529-0131 .- 0004-3591. ; 63:10, s. 2894-904
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Tidskriftsartikel (refereegranskat)abstract
- Human resistin has proinflammatory properties that activate NF-κB-dependent pathways, whereas its murine counterpart is associated with insulin resistance. The aim of this study was to examine potential cross-talk between resistin and insulin/insulin-like growth factor (IGF) signaling in rheumatoid arthritis (RA).
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| 10. |
- Erlandsson, Malin, 1972, et al.
(författare)
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Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function.
- 2013
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Ingår i: Biochimica et biophysica acta. - : Elsevier BV. - 0006-3002. ; 1833:12, s. 2653-2663
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Tidskriftsartikel (refereegranskat)abstract
- S100A4 is a Ca-binding protein that regulates cell growth, survival, and motility. The abundant expression of S100A4 in rheumatiod arthritis contributes to the invasive growth of joint tissue and to bone damage. In the present study, we analysed the role of S100A4 in bone homeostasis.
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