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| 2. |
- Heid, Iris M, et al.
(författare)
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
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Tidskriftsartikel (refereegranskat)abstract
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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| 3. |
- Speliotes, Elizabeth K., et al.
(författare)
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
- 2010
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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| 4. |
- Žliobaitė, Indrė, et al.
(författare)
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The NOW Database of Fossil Mammals
- 2023
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Ingår i: Evolution of Cenozoic Land Mammal Faunas and Ecosystems: 25 years of the NOW database of fossil mammals. - : Springer. ; , s. 33-42
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Bokkapitel (refereegranskat)abstract
- NOW (New and Old Worlds) is a global database of fossil mammal occurrences, currently containing around 68,000 locality-species entries. The database spans the last 66 million years, with its primary focus on the last 23 million years. Whereas the database contains records from all continents, the main focus and coverage of the database historically has been on Eurasia. The database includes primarily, but not exclusively, terrestrial mammals. It covers a large part of the currently known mammalian fossil record, focusing on classical and actively researched fossil localities. The database is managed in collaboration with an international advisory board of experts. Rather than a static archive, it emphasizes the continuous integration of new knowledge of the community, data curation, and consistency of scientific interpretations. The database records species occurrences at localities worldwide, as well as ecological characteristics of fossil species, geological contexts of localities and more. The NOW database is primarily used for two purposes: (1) queries about occurrences of particular taxa, their characteristics and properties of localities in the spirit of an encyclopedia; and (2) large scale research and quantitative analyses of evolutionary processes, patterns, reconstructing past environments, as well as interpreting evolutionary contexts. The data are fully open, no logging in or community membership is necessary for using the data for any purpose.
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| 5. |
- Abbasi, Rasha, et al.
(författare)
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IceCube search for neutrinos from GRB 221009A
- 2023
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Ingår i: Proceedings of 38th International Cosmic Ray Conference (ICRC 2023). - : Sissa Medialab Srl.
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Konferensbidrag (refereegranskat)abstract
- GRB 221009A is the brightest Gamma Ray Burst (GRB) ever observed. The observed extremelyhigh flux of high and very-high-energy photons provide a unique opportunity to probe the predictedneutrino counterpart to the electromagnetic emission. We have used a variety of methods to searchfor neutrinos in coincidence with the GRB over several time windows during the precursor, promptand afterglow phases of the GRB. MeV scale neutrinos are studied using photo-multiplier ratescalers which are normally used to search for galactic core-collapse supernovae neutrinos. GeVneutrinos are searched starting with DeepCore triggers. These events don’t have directionallocalization, but instead can indicate an excess in the rate of events. 10 GeV - 1 TeV and >TeVneutrinos are searched using traditional neutrino point source methods which take into accountthe direction and time of events with DeepCore and the entire IceCube detector respectively. The>TeV results include both a fast-response analysis conducted by IceCube in real-time with timewindows of T0 − 1 to T0 + 2 hours and T0 ± 1 day around the time of GRB 221009A, as well asan offline analysis with 3 new time windows up to a time window of T0 − 1 to T0 + 14 days, thelongest time period we consider. The combination of observations by IceCube covers 9 ordersof magnitude in neutrino energy, from MeV to PeV, placing upper limits across the range forpredicted neutrino emission.
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| 6. |
- Aleynick, Mark, et al.
(författare)
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Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming
- 2023
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Ingår i: Journal for ImmunoTherapy of Cancer. - : BMJ Publishing Group Ltd. - 2051-1426. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- Background Cancer immunotherapies are generallyeffective in patients whose tumors contain a prioriprimed T-cells reactive to tumor antigens (TA). Oneapproach to prime TA-reactive T-cells is to administerimmunostimulatory molecules, cells, or pathogens directlyto the tumor site, that is, in situ vaccination (ISV). Werecently described an ISV using Flt3L to expand and recruitdendritic cells (DC), radiotherapy to load DC with TA, andpattern recognition receptor agonists (PRRa) to activateTA-loaded DC. While ISV trials using synthetic PRRa haveyielded systemic tumor regressions, the optimal method toactivate DCs is unknown.Methods To discover optimal DC activators and increaseaccess to clinical grade reagents, we assessed whetherviral or bacterial components found in common pathogenvaccines are an effective source of natural PRRa(naPRRa). Using deep profiling (155-metric) of naPRRaimmunomodulatory effects and gene editing of specificPRR, we defined specific signatures and molecularmechanisms by which naPRRa potentiate T-cell priming.Results We observed that vaccine naPRRa can be evenmore potent in activating Flt3L-expanded murine andhuman DCs than synthetic PRRa, promoting cross-primingof TA-reactive T-cells. We developed a mechanisticallydiverse naPRRa combination (BCG, PedvaxHIB, Rabies)and noted more potent T-cell cross-priming than withany single naPRRa. The naPRRa triplet—as part of Flt3Lprimed ISV—induced greater intratumoral CD8 T-cellinfiltration, T-cells reactive to a newly defined tumorousneoantigen, durable tumor regressions.Conclusions This work provides rationale for thetranslation of pathogen vaccines as FDA-approved clinicalgrade DC activators which could be exploited as immunestimulants for early phase trials.
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| 7. |
- Andersson Djurfeldt, Agnes, et al.
(författare)
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Agricultural intensification and gender in Malawi, Tanzania and Zambia
- 2019
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Annan publikation (populärvet., debatt m.m.)abstract
- The SAIRLA-supported AFRINT IV project has been collecting data on agricultural intensification from23 farming communities in seven regions in Malawi, Tanzania and Zambia since 2008. Policies in allcountries have a strong focus on maize intensification and also target women as recipients ofsubsidised farm inputs. During this time, data on maize shows that only in the Zambian region hasthere been a sustained increase in yields, but this has been tied to a persistent gender gap. In theother two countries, yields have been stagnant. In the case of Malawi this is explained by poverty, landfragmentation and a gradual depletion of natural resources. In the case of Tanzania, withdrawal ofsubsidy schemes for maize in combination with new commercial opportunities in rice and tree cropsappear to be changing land use patterns.Despite these differences, women are united by some common characteristics: generally womenexperience mobility constraints as a result of domestic chores and socially restrictive norms. Moreover,the condition for co-financing to access subsidies disadvantages poorer households – many of whichare headed by women. Finally, women’s access to labour is limited, both that of men in particular, butalso the drudgery of their own domestic tasks and care burdens imposes restrictions on their time. Theseasonality of smallholder agriculture means that the effects of these shortages on intensification areaggravated.Policies need to redress all of these aspects, for instance through rural electrification and expandingbasic healthcare for children, encouraging small scale enterprises among women and gendersensitisation campaigns that involve men as well as women.
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| 8. |
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| 9. |
- Andersson Djurfeldt, Agnes, et al.
(författare)
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Is there such a thing as sustainable agricultural intensification in smallholder-based farming in sub-Saharan Africa? Understanding yield differences in relation to gender in Malawi, Tanzania and Zambia
- 2019
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Ingår i: Development Studies Research. - : Informa UK Limited. - 2166-5095. ; 6:1, s. 62-75
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Tidskriftsartikel (refereegranskat)abstract
- Smallholder-based, sustainable, agricultural intensification is increasingly put forth as a development pathway that is necessary to improve farmer's livelihoods, enhance productivity and engender a surplus that can be used to feed growing urban areas across sub-Saharan Africa. The following article examines trends in yields for Africa's largest staple crop – maize – among smallholder farmers in six regions in Malawi, Tanzania and Zambia, using longitudinal quantitative data collected in 2008, 2013 and 2017 in combination with qualitative data from nine villages. Substantial increases in yields are found only in Zambia, while yields are largely stagnant in Malawi and Tanzania. In the case of Zambia, however, there is a persistent gender-based yield gap. We use the qualitative data to explain this gap and find that gender-based differences in yields need to be understood in relation to local production systems, as well as the varied positionality of women, where the biases facing women who head their own households are different than for women living in male headed households. In policy terms, technologies that can promote intensification are different depending on these factors, even within the local context of particular farming systems.
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| 10. |
- Andersson Djurfeltd, Agnes, et al.
(författare)
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The Gendered Possibilities for Participating in Agricultural Intensification in Sub-Saharan Africa – a Longitudinal Perspective from Seven Regions in Malawi, Tanzania and Zambia
- 2020
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Ingår i: SSRN Electronic Journal. - : Elsevier BV. - 1556-5068.
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This paper looks at the gendered possibilities for participating in agricultural intensification in seven regions in Malawi, Zambia and Tanzania, using a longitudinal, regional, mixed methods approach combining household level data on land, labour and use of agricultural techniques for male and female farm managers as well as qualitative data collected from within male-headed households and community level data. The analysis is based on a quantitative dataset covering 1070 small scale farmers covering the period 2002 to 2017/18, as well as around roughly 350 qualitative interviews collected over the course of a decade. The results point to great variation between the regions as well as the countries in terms of access to land, but also suggest that gender relations around land are changing as a result both of deliberate policies as well as the emergence of rental markets for land. Indeed, gender-based gaps in cultivated area have fallen in some regions, but are persistent in others. Surprisingly, neither tenure security nor formalisation of tenure is differentiated between male and female respondents, in any of the regions. Access to family labour is however smaller on female managed farms and labour shortages are generally higher on these farms in most regions. Capital and labour intensive technologies add to gender based differentiation in cultivated area in regions where commercial opportunities are driving intensification, whereas gender based gaps in the use of these technologies have narrowed in poor regions as a result of deteriorating conditions for male farmers.
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