| 1. |
- Alcalde, Juan, et al.
(författare)
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3D geological characterization of the Hontomin CO2 storage site, Spain : Multidisciplinary approach from seismic, well-log and regional data
- 2014
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Ingår i: Tectonophysics. - : Elsevier BV. - 0040-1951 .- 1879-3266. ; 627, s. 6-25
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Tidskriftsartikel (refereegranskat)abstract
- The first Spanish Technological Development plant for CO2 storage is currently under development in Hontomin (Spain), in a fractured carbonate reservoir. The subsurface 3D geological structures of the Hontomin site were interpreted using well-log and 3D seismic reflection data. A shallow low velocity zone affects the wave propagation and decreases the coherency of the underlying seismic reflections, deteriorating the quality of the seismic data, and thus preventing a straightforward seismic interpretation. In order to provide a fully constrained model, a geologically supervised interpretation was carried out. In particular, a conceptual geological model was derived from an exhaustive well-logging analysis. This conceptual model was then improved throughout a detailed seismic facies analysis on selected seismic sections crossing the seismic wells and in consistency with the regional geology, leading to the interpretation of the entire 3D seismic volume. This procedure allowed characterizing nine main geological levels and four main fault sets. Thus, the stratigraphic sequence of the area and the geometries of the subsurface structures were defined. The resulting depth-converted 3D geological model allowed us to estimate a maximum CO2 storage capacity of 5.85 Mt. This work provides a 3D geological model of the Hontomin subsurface, which is a challenging case study of CO2 storage in a complex fractured carbonate reservoir.
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| 2. |
- Ayarza, Puy, et al.
(författare)
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Evolution of the Iberian Massif as deduced from its crustal thickness and geometry of a mid-crustal (Conrad) discontinuity
- 2021
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Ingår i: Solid Earth. - : Copernicus Publications. - 1869-9510 .- 1869-9529. ; 12:7, s. 1515-1547
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Tidskriftsartikel (refereegranskat)abstract
- Y Normal incidence seismic data provide the best images of the crust and lithosphere. When properly designed and continuous, these sections greatly contribute to understanding the geometry of orogens and, along with surface geology, unraveling their evolution. In this paper we present the most complete transect, to date, of the Iberian Massif, the westernmost exposure of the European Variscides. Despite the heterogeneity of the dataset, acquired during the last 30 years, the images resulting from reprocessing the data with a homogeneous workflow allow us to clearly define the crustal thickness and its internal architecture. The Iberian Massif crust, formed by the amalgamation of continental pieces belonging to Gondwana and Laurussia (Avalonian margin), is well structured in the upper and lower crust. A conspicuous mid-crustal discontinuity is clearly defined by the top of the reflective lower crust and by the asymptotic geometry of reflections that merge into it, suggesting that it has often acted as a detachment. The geometry and position of this discontinuity can give us insights into the evolution of the orogen (i.e., of the magnitude of compression and the effects and extent of later-Variscan gravitational collapse). Moreover, the limited thickness of the lower crust below, in central and northwestern Iberia, might have constrained the response of the Iberian microplate to Alpine shortening. Here, this discontinuity, featuring a Vp (P-wave velocity) increase, is observed as an orogen-scale boundary with characteristics compatible with those of the globally debated Conrad discontinuity.
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| 3. |
- Batra, Gorav, et al.
(författare)
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Data standards for atrial fibrillation/flutter and catheter ablation : The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart)
- 2023
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Ingår i: European Heart Journal - Quality of Care and Clinical Outcomes. - : Oxford University Press. - 2058-5225 .- 2058-1742. ; 9:6, s. 609-620
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: Standardized data definitions are essential for monitoring and assessment of care and outcomes in observational studies and randomized controlled trials (RCTs). The European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart) project of the European Society of Cardiology aimed to develop contemporary data standards for atrial fibrillation/flutter (AF/AFL) and catheter ablation.METHODS AND RESULTS: We used the EuroHeart methodology for development of data standards and formed a Working Group comprising 23 experts in AF/AFL and catheter ablation registries, as well as representatives from the European Heart Rhythm Association and EuroHeart. We conducted a systematic literature review of AF/AFL and catheter ablation registries and data standard documents to generate candidate variables. We used a modified Delphi method to reach consensus on a final variable set. For each variable, the Working Group developed permissible values and definitions, and agreed as to whether the variable was mandatory (Level 1) or additional (Level 2). In total, 70 Level 1 and 92 Level 2 variables were selected and reviewed by a wider Reference Group of 42 experts from 24 countries. The Level 1 variables were implemented into the EuroHeart IT platform as the basis for continuous registration of individual patient data.CONCLUSION: By means of a structured process and working with international stakeholders, harmonized data standards for AF/AFL and catheter ablation for AF/AFL were developed. In context of the EuroHeart project, this will facilitate country-level quality of care improvement, international observational research, registry-based RCTs and post-marketing surveillance of devices and pharmacotherapies.
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| 4. |
- Gee, David G., et al.
(författare)
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Collisional Orogeny in the Scandinavian Caledonides (COSC)
- 2010
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Ingår i: GFF. - : Informa UK Limited. - 1103-5897 .- 2000-0863. ; 132:1, s. 29-44
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Tidskriftsartikel (refereegranskat)abstract
- The COSC project is focused on the mid Paleozoic Caledonide Orogen in Scandinavia in order to better understand orogenic processes, both in the past and in today's active mountain belts. It relates to two of ICDP's main themes - the fundamental physics of plate tectonics and heat, mass and fluid transfer through Earth's crust, and on improving interpretation of geophysical data used to determine the structure and properties of the Earth's crust. Lateral transport of Caledonian allochthons over distances of several hundreds of kilometers in the Scandes, by a combination of thrusting and ductile extrusion, is comparable to that recognized in the Himalayas. The Caledonides in Scandinavia provide special opportunities for understanding Himalayan-type orogeny and the Himalayan Orogen itself, thanks to the deep level of erosion and the paucity of superimposed post-Paleozoic deformation. The surface geology in combination with the seismic, magnetotelluric, magnetic and gravity data provide control of the geometry of the Caledonian structure, both of the allochthon and the underlying parautochthon-autochthon, and define the locations for drilling. The latter will investigate both the high-grade, ductile Caledonian nappes and the underlying allochthons and basement, with two c. 2.5km deep boreholes, located near re and Jarpen in western Jamtland. The two boreholes will also provide unique information about other important aspects of the Scandinavian bedrock, including the heat flow and potential for geothermal energy, mineralization in the Seve nappes and alum shales, the uplift history of the Scandes, the Holocene paleoclimatological changes and the deep biosphere.
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| 5. |
- Gothefors, Dan, et al.
(författare)
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Swedish clinical guidelines-Prevention and management of metabolic risk in patients with severe psychiatric disorders
- 2010
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Ingår i: Nordic Journal of Psychiatry. - : Informa UK Limited. - 1502-4725 .- 0803-9488. ; 64:5, s. 294-302
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Tidskriftsartikel (refereegranskat)abstract
- Individuals with severe psychiatric disorders are more likely than the population at large to develop metabolic derangements such as overweight and diabetes. Cardiovascular disease is also more frequently seen in this group. Contributing factors may include inappropriate diet or lack of physical activity, but antipsychotic medication may also play a role. Seven Swedish specialist medical societies have collaborated in formulating a set of concise clinically applicable guidelines-reproduced here in modified form-for the prevention and management of metabolic risk in this patient group. The importance of implementation is emphasized.
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| 6. |
- Hedin, Peter, 1981-, et al.
(författare)
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3D interpretation by integrating seismic and potential field data in the vicinity of the proposed COSC-1 drill site, central Swedish Caledonides
- 2014
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Ingår i: Geological Society Special Report. - : Geological Society. - 0309-670X. ; 390, s. 301-319
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Tidskriftsartikel (refereegranskat)abstract
- The scientific drilling project COSC (Collisional Orogeny in the Scandinavian Caledonides), designed to study key questions concerning orogenic processes, aims to drill two fully cored boreholes to depths of c. 2.5 km each at carefully selected locations in west-central Sweden. The first of these, COSC-1, is scheduled for start late spring 2014 and will target the Seve Nappe Complex, characterized by inverted metamorphism and with parts that have evidently been subjected to hot ductile extrusion. In this study available seismic sections have been combined with surface geology to produce a 3D interpretation of the tectonic structures in the vicinity of the COSC-1 borehole. Constrained 3D inverse gravity modelling over the same area supports the interpretation, and the high-density Seve Nappe Complex stands out clearly in the model. Interpretation and models show that the maximum depth extent of the Seve Nappe Complex is less than 2.5 km, consistent with reflection seismic data. The gravity modelling also requires underlying units to comprise low-density material, consistent with the Lower Allochthon, but the modelling is unable to discern the décollement separating the allochthons from the crystalline Precambrian basement.
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| 7. |
- Hedin, Peter, et al.
(författare)
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COSC Geophysical and Geological Site Investigations
- 2013
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Konferensbidrag (refereegranskat)abstract
- Drilling of the first borehole, about 2.5 km deep, for the continental scientific deep drilling project COSC(Collisional Orogeny in the Scandinavian Caledonides) is scheduled to begin in the summer of 2013. Herewe present the project, a 3D interpretation of seismic data, combined with surface geology and potentialfield data, used for locating the most suitable drill site and planning of the drilling. An evaluation of theseismic interpretations by constrained 3D inverse modeling of potential field data shows a good fit toobserved data, further supporting the choice of the drill site.
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| 8. |
- Hedin, Peter, et al.
(författare)
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Seismic imaging of the Scandinavian Caledonides to define ICDP drilling sites
- 2012
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Ingår i: Tectonophysics. - : Elsevier. - 0040-1951 .- 1879-3266. ; 554-557, s. 30-41
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Tidskriftsartikel (refereegranskat)abstract
- A 36 kilometer long high resolution 2D seismic reflection profile was acquired in the summer of 2010 to be used in the planning of the COSC (Collisional Orogeny in the Scandinavian Caledonides) Deep Drilling Project. Two fully cored boreholes, each to c. 2.5 km depth, are planned for the Are-Morsil area of west-central Sweden in order to increase our understanding of orogenic processes and, in particular, the tectonic evolution of the Scandinavian Caledonides.Besides providing important sub-surface structural information in the vicinity of the potential drill sites, the seismic profile also provides detailed, high resolution images previously not available for the uppermost few kilometers in the region. The subsurface is highly reflective and very complex down to at least 9 km depth (the limit of decoded data) with clear reflections spanning the entire length of the profile.Correlation with previous regional reflection seismic and magnetotelluric surveys has been achieved by acquisition of a short (7 km) connecting profile. A clearly defined reflection, present in the new profile at depths between c. 2.5 km in the east and c. 4.5 km in the west and with an average westwards dip of c. 3.5 degrees, apparently defines the base of the Lower Allochthon. Closer to the Caledonian front, this sole thrust overlies the Cambrian alum shale formation, which rests unconformably on the autochthonous Precambrian crystalline basement. The latter is remarkable for its deep internal reflectivity which is probably related to mafic intrusions in a dominantly granitic host-rock: their deformation may be of both Caledonian and older (e.g. Sveconorwegian) age.The new high resolution seismic data provide the basis for locating the first borehole in the Seve Nappe Complex. They also demonstrate that the second hole, designed to penetrate the Caledonian basement, will have to be located further east than was originally planned.
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| 9. |
- Juhlin, Christopher, et al.
(författare)
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Seismic imaging in the eastern Scandinavian Caledonides: Siting the 2.5 km deep COSC-2 borehole, central Sweden
- 2016
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Ingår i: Solid Earth. - : Copernicus GmbH. - 1869-9510 .- 1869-9529. ; 7:3, s. 769-787
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Tidskriftsartikel (refereegranskat)abstract
- The Collisional Orogeny in the Scandinavian Caledonides (COSC) project, a contribution to the International Continental Scientific Drilling Program (ICDP), aims to provide a deeper understanding of mountain belt dynamics. Scientific investigations include a range of topics, from subduction-related tectonics to the present-day hydrological cycle. COSC investigations and drilling activities are focused in central Scandinavia where rocks from the mid to lower crust of the orogen are exposed near the Swedish-Norwegian border. Here, rock units of particular interest occur in the Seve Nappe Complex (SNC) of the so-called Middle Allochthon and include granulite facies migmatites (locally with evidence of ultra-high pressures) and amphibolite facies gneisses and mafic rocks. This complex overlies greenschist facies metasedimentary rocks of the dolerite-intruded Särv Nappes and underlying, lower grade Jämtlandian Nappes (Lower Allochthon). Reflection seismic profiles have been an important component in the activities to image the sub-surface structure in the area. Sub-horizontal reflections in the upper 1-2 km are underlain and interlayered with strong west- to northwest-dipping reflections, suggesting significant east-vergent thrusting. Two 2.5 km deep fully cored boreholes are a major component of the project which will improve our understanding of the sub-surface structure and tectonic history of the area. Borehole COSC-1 (IGSN: http://hdl.handle.net/10273/ICDP5054EEW1001), drilled in the summer of 2014, targeted the subduction-related Seve Nappe Complex and the contact with the underlying allochthon. The COSC-2 borehole will be located further east and investigate the lower grade, mainly Cambro-Silurian rocks of the Lower Allochthon, the Jämtlandian décollement and penetrate into the crystalline basement rocks to identify the source of some of the northwest-dipping reflections. A series of high resolution seismic profiles have been acquired along a composite c. 55 km long profile to help locate the COSC drill holes. We present here the results from this COSC-related composite seismic profile (CSP), including new interpretations based on previously unpublished data acquired between 2011 and 2014. These seismic data, along with shallow drill holes in the Caledonian thrust front and previously acquired seismic, magnetotelluric, and magnetic data, are used to identify two potential drill sites for the COSC-2 borehole.
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| 10. |
- Laurell, Cecilia, et al.
(författare)
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Transcriptional profiling enables molecular classification of adrenocortical tumours
- 2009
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Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 161:1, s. 141-152
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Tumours in the adrenocortex are common human tumours. Malignancy is however, rare, the yearly incidence being 0.5-2 per million inhabitants, but associated with a very aggressive behaviour. Adrenocortical tumours are often associated with altered hormone production with a variety of clinical symptoms. The aggressiveness of carcinomas together with the high frequency of adenomas calls for a deeper understanding of the underlying biological mechanisms and an improvement of the diagnostic possibilities. Methods: Microarray gene expression analysis was performed in tumours of adrenocortex with emphasis on malignancy as well as hormonal activity. The sample set consisted of 17 adenomas, 11 carcinomas and 4 histological normal adrenocortexes. RNA from these was hybridised according to a reference design on microarrays harbouring 29 760 human cDNA clones. Confirmation was performed with quantitative real time-PCR and western blot analysis. Results: Unsupervised clustering to reveal relationships between samples based on the entire gene expression profile resulted in two subclusters; carcinomas and non-cancer specimens. A large number of genes were accordingly found to be differentially expressed comparing carcinomas to adenomas. Among these were IGF2, FGFR1 and FGFR4 in growth factor signalling the most predominant and also the USP4, UBE2C and UFD1L in the ubiquitin-proteasome pathway. Moreover, two subgroups of carcinomas were identified with different survival outcome, suggesting that survival prediction can be made on the basis of gene expression profiles. Regarding adenomas with aldosterone overproduction, OSBP and VEGFB were among the most up-regulated genes compared with the other samples. Conclusions: Adrenocortical carcinomas are associated with a distinct molecular signature apparent in their gene expression profiles. Differentially expressed genes were identified associated with malignancy, survival as well as hormonal activity providing a resource of candidate genes for an exploration of possible drug targets and diagnostic and prognostic markers.
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