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- Bolling-Sternevald, E, et al.
(författare)
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Do gastrointestinal symptoms fluctuate in the short-term perspective? The Kalixanda study
- 2008
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Ingår i: Digestive diseases (Basel, Switzerland). - : S. Karger AG. - 1421-9875 .- 0257-2753. ; 26:3, s. 256-263
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Tidskriftsartikel (refereegranskat)abstract
- <i>Background/Aim:</i> Short-term fluctuation of gastrointestinal symptoms in the general population is largely unknown. We aimed to determine gastrointestinal symptom fluctuation in an random adult population using a validated questionnaire assessing gastrointestinal symptoms. <i>Methods:</i> A representative sample (n = 2,860) of the population (n = 21,610, 20–81 years of age; mean age 50.4 years) in Northern Sweden was studied. The subjects were asked to complete the questionnaire on two occasions [mean 2.5 months (range 1–6)], firstly via mail and secondly at a visit to the clinic. An upper endoscopy was performed after the last assessment of symptoms. <i>Results:</i> 2,122 individuals (74.2%) completed the initial questionnaire; 1,001 of these (mean age 54.1 years, 48.8 males) completed the second questionnaire. On the first occasion, 40% of the subjects were symptom-free (20.2%) or could not be classified according to their symptom pattern, of those with symptoms 39% reported troublesome reflux symptoms, 40% dyspeptic symptoms and 30% irritable bowel symptoms. Symptom overlap occurred in more than two thirds of the subjects. At the second visit 75% of the subjects who had reported dyspeptic complaints still reported such complaints. <i>Conclusions:</i> In this population-based study, gastrointestinal symptoms were common. Some symptom fluctuation occurred in the shorter term, but troublesome gastrointestinal complaints remained in approximately 90% of subjects over a 1–6-month period.
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- Ronkainen, J., et al.
(författare)
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Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population--the Kalixanda study
- 2006
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Ingår i: Alimentary Pharmacology and Therapeutics. - : Wiley. - 0269-2813 .- 1365-2036. ; 23:12, s. 1725-1733
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Tidskriftsartikel (refereegranskat)abstract
- Background The impact of gastro-oesophageal reflux symptoms on health-related quality of life in the general population is poorly characterized. Aim To identify the frequency of troublesome reflux symptoms associated with impaired health-related quality of life in the general population. Methods A representative random sample of 3000 adult inhabitants of northern Sweden was surveyed using the validated Abdominal Symptom Questionnaire (response rate 74%). In total, 1001 random responders were endoscoped and assessed using the Short Form-36 Health Survey. Results Complete data were obtained for 999 subjects: 6% reported reflux symptoms (heartburn and/or regurgitation) daily, 14% weekly and 20% less than weekly during the previous 3 months. Compared with no reflux symptoms, a clinically relevant impairment of health-related quality of life (≥5 points and P < 0.05) was seen in all eight Short Form-36 dimensions for daily symptoms, in five dimensions for weekly symptoms and in one dimension for less than weekly symptoms. There were no meaningful differences in Short Form-36 scores between subjects with and without oesophagitis. Conclusions Most aspects of health-related quality of life were impaired in individuals with daily or weekly reflux symptoms. Troublesome reflux symptoms at least weekly may identify gastro-oesophageal reflux disease.
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