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- Kabir, Nuzhat N., et al.
(författare)
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Deregulation of protein phosphatase expression in acute myeloid leukemia
- 2013
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Ingår i: Medical Oncology. - : Springer Science and Business Media LLC. - 1559-131X .- 1357-0560. ; 30:2
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Tidskriftsartikel (refereegranskat)abstract
- Acute myeloid leukemia (AML) is a highly malignant disease of myeloid cell line. AML is the most frequent adult leukemia with inadequate treatment possibility. The protein phosphatases are critical regulators of cell signaling, and deregulation of protein phosphatases always contribute to cell transformation. Although many studies established a relationship between protein phosphatases and leukemia, little is known about the role of this group of proteins in AML. To address this issue, we initially identified the complete catalog of human protein phosphatase genes and used this catalog to study deregulation of protein phosphatases in AML. Using mRNA expression data of AML patients, we show that 11 protein phosphatases are deregulated in AML within 174 protein phosphatases. The GO enrichment study suggests that these genes are involved in multiple biological processes other than protein de-phosphorylation. Expression of DUSP10, PTPRC, and PTPRE was significantly higher than average expression in AML, and a linear combination of DUSP10, MTMR11, PTPN4, and PTPRE expressions provides important information about disease subtypes. Our results provide an overview of protein phosphatase deregulation in AML.
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| 2. |
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| 3. |
- Kabir, Nuzhat N., et al.
(författare)
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GRB10
- 2016. - 2nd
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Ingår i: Encyclopedia of Signaling Molecules. - New York, NY : Springer New York. - 9781461464389 - 9781461464389 ; , s. 1-4
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Bokkapitel (refereegranskat)
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| 4. |
- Kabir, Nuzhat N., et al.
(författare)
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Grb10 is a dual regulator of receptor tyrosine kinase signaling
- 2014
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Ingår i: Molecular Biology Reports. - : Springer Science and Business Media LLC. - 0301-4851 .- 1573-4978. ; 41:4, s. 1985-1992
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Forskningsöversikt (refereegranskat)abstract
- The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras–GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.
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| 5. |
- Kabir, Nuzhat N., et al.
(författare)
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Keratin 19 expression correlates with poor prognosis in breast cancer
- 2014
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Ingår i: Molecular Biology Reports. - : Springer Science and Business Media LLC. - 0301-4851 .- 1573-4978. ; 41:12, s. 7729-7735
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients. Furthermore, KRT19 expression was associated with ER up-regulation and Luminal B gene signatures, as well as a constitutive RAF1 signaling pathway. Finally, KRT19 expression correlated with poor overall survival. Taken together, our results suggest that KRT19 expression can be used as a prognostic marker.
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| 7. |
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| 8. |
- Kabir, Nuzhat N., et al.
(författare)
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SOCS6 is a selective suppressor of receptor tyrosine kinase signaling
- 2014
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Ingår i: Tumor Biology. - : Springer Science and Business Media LLC. - 1423-0380 .- 1010-4283. ; 35:11, s. 10581-10589
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Forskningsöversikt (refereegranskat)abstract
- The suppressors of cytokine signaling (SOCS) are well-known negative regulators of cytokine receptor signaling. SOCS6 is one of eight members of the SOCS family of proteins. Similar to other SOCS proteins, SOCS6 consists of an uncharacterized extended N-terminal region followed by an SH2 domain and a SOCS box. Unlike other SOCS proteins, SOCS6 is mainly involved in negative regulation of receptor tyrosine kinase signaling. SOCS6 is widely expressed in many tissues and is found to be downregulated in many cancers including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, stomach cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer. SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces apoptosis by targeting mitochondrial proteins. Therefore, SOCS6 turns out as an important regulator of survival signaling and its activity is required for controlling receptor tyrosine kinase signaling.
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| 10. |
- Kazi, Julhash U., et al.
(författare)
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BEX3
- 2017
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Ingår i: Encyclopedia of Signaling Molecules. - New York, NY : Springer New York. - 9781461464389 ; , s. 1-4
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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