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Numrering	Referens	Omslagsbild	Hitta
1.	Permyakov, E A, et al. (författare) alpha-Lactalbumin binds magnesium ions : study by means of intrinsic fluorescence technique. 1981 Ingår i: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 102:1, s. 1-7 Tidskriftsartikel (refereegranskat)
2.	Permyakov, E A, et al. (författare) Calcium binding to alpha-lactalbumin : structural rearrangement and association constant evaluation by means of intrinsic protein fluorescence changes. 1981 Ingår i: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 100:1, s. 191-7 Tidskriftsartikel (refereegranskat)
3.	Permyakov, E A, et al. (författare) Interaction of alpha-lactalbumin with Cu2+. 1988 Ingår i: Biophysical Chemistry. - 0301-4622 .- 1873-4200. ; 32:1, s. 37-42 Tidskriftsartikel (refereegranskat)abstract It has been shown by intrinsic fluorescence spectroscopy that alpha-lactalbumin has several Cu2+ -binding sites per molecule. The Ca2+ -loaded protein binds two or more Cu2+ per molecule with an association constant of about 3 X 10(3) M-1. Apo-alpha-lactalbumin binds one Cu2+ per molecule with association constant 8 X 10(4) M-1 and from two to three Cu2+ with an association constant of about 4 X 10(3) M-1. The results obtained from spectrofluorometric pH titration of alpha-lactalbumin in the acidic pH region show the possible involvement of histidine residues in the coordination of Cu2+. The binding of Cu2+ to alpha-lactalbumin lowers significantly its thermostability and stability towards urea denaturation. The stability of Cu2+, Ca2+-alpha-lactalbumin against thermal and urea denaturation is similar to that of the apo protein. The thermal transition in Cu2+, Ca2+-alpha-lactalbumin occurs within the region of physiological temperatures which may suggest the existence of some thermal regulation of its functioning in vivo.
4.	Serwas, NK, et al. (författare) Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis 2019 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 3106- Tidskriftsartikel (refereegranskat)abstract Immune responses need to be controlled tightly to prevent autoimmune diseases, yet underlying molecular mechanisms remain partially understood. Here, we identify biallelic mutations in three patients from two unrelated families in differentially expressed in FDCP6 homolog (DEF6) as the molecular cause of an inborn error of immunity with systemic autoimmunity. Patient T cells exhibit impaired regulation of CTLA-4 surface trafficking associated with reduced functional CTLA-4 availability, which is replicated in DEF6-knockout Jurkat cells. Mechanistically, we identify the small GTPase RAB11 as an interactor of the guanine nucleotide exchange factor DEF6, and find disrupted binding of mutant DEF6 to RAB11 as well as reduced RAB11+CTLA-4+ vesicles in DEF6-mutated cells. One of the patients has been treated with CTLA-4-Ig and achieved sustained remission. Collectively, we uncover DEF6 as player in immune homeostasis ensuring availability of the checkpoint protein CTLA-4 at T-cell surface, identifying a potential target for autoimmune and/or cancer therapy.
5.	Serwas, NK, et al. (författare) Publisher Correction: Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis 2019 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4555- Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Resultat 1-5 av 5

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Typ av publikation: tidskriftsartikel (5)

Typ av innehåll: refereegranskat (4); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Permyakov, E A (3); Kalinichenko, L P (3); Morozova, L A (3); Bryceson, YT (2); Mukherjee, M. (2); Orange, JS (2); visa fler...; Kennedy, A (2); Boztug, K (2); Meffre, E (2); Tesi, B (2); Priftakis, P (2); Huemer, J (2); Meeths, M (2); Hoeger, B (2); Hou, TZ (2); Sansom, DM (2); Loizou, JI (2); Kain, R (2); Sui, ZH (2); Altman, A (2); Kalinichenko, A (2); Banerjee, PP (2); Mace, EM (2); Yarmolenko, V V (2); Burstein, E A (2); Thiel, J (2); Santos-Valente, E (2); Serwas, NK (2); Ardy, RC (2); Stulz, SV (2); Memaran, N (2); Krolo, A (2); Petronczki, OY (2); Pfajfer, L (2); Halliday, N (2); Schrempf, A (2); Bidmon-Fliegenschnee ... (2); Schickel, JN (2); Glauzy, S (2); Garncarz, W (2); Salzer, E (2); Pierides, I (2); Bilic, I (2); Medgyesi, D (2); Huber, WD (2); Forster-Waldl, E (1); Derezhkov, V Yu (1); Pickl, WF (1); Foerster-Waldl, E (1); visa färre...

Lärosäte: Umeå universitet (3); Karolinska Institutet (2)

Språk: Engelska (5)

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