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- Kamio, S., et al.
(författare)
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First experiments on plasma production using field-aligned ICRF fast wave antennas in the large helical device
- 2021
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Ingår i: Nuclear Fusion. - : Institute of Physics (IOP). - 0029-5515 .- 1741-4326. ; 61:11
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Tidskriftsartikel (refereegranskat)abstract
- The results of the first experimental series to produce a plasma using the ion cyclotron range of frequency (ICRF) in the large helical device (LHD) within the minority scenario developed at Uragan-2M (U-2M) are presented. The motivation of this study is to provide plasma creation in conditions when an electron cyclotron resonance heating start-up is not possible, and in this way widen the operational frame of helical machines. The major constraint of the experiments is the low RF power to reduce the possibility of arcing. No dangerous voltage increase at the radio-frequency (RF) system elements and no arcing has been detected. As a result, a low plasma density is obtained and the antenna-plasma coupling is not optimal. However, such plasmas are sufficient to be used as targets for further neutral beam injection (NBI) heating. This will open possibilities to explore new regimes of operation at LHD and Wendelstein 7-X (W7-X) stellarator. The successful RF plasma production in LHD in this experimental series stimulates the planning of further studies of ICRF plasma production aimed at increasing plasma density and temperature within the ICRF minority scenario as well as investigating the plasma prolongation by NBI heating.
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- Togo, S, et al.
(författare)
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PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts
- 2009
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Ingår i: American journal of physiology. Lung cellular and molecular physiology. - : American Physiological Society. - 1040-0605 .- 1522-1504. ; 296:6, s. L959-L969
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Tidskriftsartikel (refereegranskat)abstract
- Fibrotic diseases are characterized by the accumulation of extracellular matrix together with distortion and disruption of tissue architecture. Phosphodiesterase (PDE)4 inhibitors, by preventing the breakdown of cAMP, can inhibit fibroblast functions and may be able to mitigate tissue remodeling. Transforming growth factor (TGF)-β1, a mediator of fibrosis, can potentially modulate cAMP by altering PGE2 metabolism. The present study assessed whether PDE4 inhibitors functionally antagonize the profibrotic activity of fibroblasts stimulated by TGF-β1. The PDE4 inhibitors roflumilast and rolipram both inhibited fibroblast-mediated contraction of three-dimensional collagen gels and fibroblast chemotaxis toward fibronectin in the widely studied human fetal lung fibroblast strain HFL-1 and several strains of fibroblasts from adult human lung. Roflumilast was ∼10-fold more potent than rolipram. There was a trend for PDE4 inhibitors to inhibit more in the presence of TGF-β1 (0.05 < P < 0.08). The effect of the PDE4 inhibitors was mediated through cAMP-stimulated protein kinase A (PKA), although a PKA-independent effect on gel contraction was also observed. The effect of PDE4 inhibitors depended on fibroblast production of PGE2 and TGF-β1-induced PGE2 production. PDE4 inhibitors together with TGF-β1 resulted in augmented PGE2 production together with increased expression of COX mRNA and protein. The present study supports the concept that PDE4 inhibitors may attenuate fibroblast activities that can lead to fibrosis and that PDE4 inhibitors may be particularly effective in the presence of TGF-β1-induced fibroblast stimulation.
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- Hirohashi, Junji, et al.
(författare)
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Embryonic nucleation method for fabrication of uniform periodically poled structures in potassium niobate for wavelength conversion devices
- 2004
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Ingår i: Japanese journal of applied physics. - 0021-4922. ; 43:2, s. 559-566
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Tidskriftsartikel (refereegranskat)abstract
- A new electric poling concept called the 'embryonic nucleation method' for the fabrication of periodically poled structures has been proposed. By applying this method to KNbO3, 1-mm-thick uniform periodically poled KNbO3 (PPKN) with domain inverted period of 35.5 mum and an interaction length of 10 mm has been successfully fabricated by applying only 300 V/mm without the generation of unwanted domains. Furthermore, the reproducibility of the periodic poling process has been greatly improved. SHG using PPKN fabricated by this method was demonstrated and 100 mW second-harmonic laser generation at a wavelength of 532 nm was obtained from 1 W pumping without photorefractive damage at approximately 40 degrees C.
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- Hirohashi, Junji, et al.
(författare)
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Total refraction of p-polarized light at the 90-degree domain boundary in the ferroelectric crystal
- 2004
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Ingår i: Japanese Journal of Applied Physics. - 0021-4922 .- 1347-4065. ; 43:6A, s. 3413-3418
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Tidskriftsartikel (refereegranskat)abstract
- A 90.DEG.-domain structure was fabricated using electrical poling in ferroelectric birefringent KNbO3 crystal. The refraction and reflection characteristics of the light at the boundary of the 90.DEG.-domain structure were investigated, and the novel behavior of total refraction (no reflection) has been found for the P-polarized light throughout the entire range of incident angle (0.LEQ..THETA..LEQ.90.DEG.). Strong refraction of the light was observed after it exited from the crystal output surface at the incidence parallel to the domain boundary. These behaviors were explained analytically. (author abst.)
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- KOVTUN, Yurii V., et al.
(författare)
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ICRF Plasma Production with the W7-X Like Antenna in the Uragan-2M Stellarator
- 2022
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Ingår i: Plasma and Fusion Research. - : Japan Society of Plasma Science and Nuclear Fusion Research. - 1880-6821. ; 17:0
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Tidskriftsartikel (refereegranskat)abstract
- The results of the plasma start-up with ICRH of U-2M RF discharges in H2+He mixture with newly implemented controlled gas H2 concentration are presented. The W7-X like ICRH antenna operated in monopole phasing with applied RF power of ∼ 100 kW. We investigated plasma start-up in the pressure range p = 6×10−4 - 9 × 10−2 Pa. Plasma production with an average density of up to Ne ∼ 1013 cm−3 was observed at frequencies the fundamental harmonic of the hydrogen cyclotron frequency.
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