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- Niemi, MEK, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Shu, X, et al.
(författare)
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Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 1217-
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Tidskriftsartikel (refereegranskat)abstract
- Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10−8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.
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- Wang, XP, et al.
(författare)
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Evapotranspiration of Artemisia ordosica vegetation in stabilized arid desert dune in Shapotou, China
- 2004
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Ingår i: Arid Land Research and Management. - : Informa UK Limited. - 1532-4982 .- 1532-4990. ; 18:1, s. 63-76
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Tidskriftsartikel (refereegranskat)abstract
- More than 40 years of revegetation using mainly Artemisia ordosica, Hedysarum scoparium, and Caragana korshinskii at Shapotou Desert Experimental Research Station near Lanzhou has established a dwarf-shrub and herbaceous cover on the stabilized sand dunes. The evapotranspiration (ET) of the xerophyte dwarf-shrub A. ordosica plant vegetation was measured by the autoweighing lysimeter method during the growing seasons from 1990 to 1995, and 2002 on the southeast edge of the Tengger Desert at Shapotou, China. The study showed that the average ET rates were 0.88 mm d(-1), and they varied from 0.6 mm d(-1) to 1.31 mm d(-1) during the 7-year experimental period from 1990 to 1995, and 2002. The ratios of ET/Precipitation (P) varied from 69.8% to 120.9% with an average of 90.9%. The higher ET/P value in 1991 was associated with the properties of intra year distribution of rainfall events, and resulted in soil moisture depletion. The correlation between the accumulative P and the accumulative ET was quite high. For the years 1990, 1993, and 1995, the relationship between the accumulative ET and the accumulative P had a closed linear relationship, resulting from the higher intensity of monthly P exceeding 40% of the overall P during the growing season. Whatever the variation in the monthly P, statistics showed that the relationship between the accumulative P and ET could be expressed as an equation, ET=0.8003 P+5.8914, with a correlation coefficient of R-2=0.9035. Results suggest that in areas similar to Shapotou it is practical to establish an artificial protection belt using xerophytic shrubs.
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