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- Meirelles, Luiz, 1974, et al.
(författare)
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Effect of hydroxyapatite and titania nanostructures on early in vivo bone response
- 2008
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Ingår i: Clinical Implant Dentistry and Related Research. - : Wiley. - 1708-8208 .- 1523-0899. ; 10:4, s. 245-254
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Hydroxyapatite or titania nano structures were applied on smooth titanium implant cylinders. The aim was to investigate whether nano HA may result in enhanced osseointegration compared to nano titania structures. Material and Methods: Surface topography evaluation included detailed characterization of nano size structures present at the implant surface combined with surface roughness parameters at the micro- and nano- meter level of resolution. Microstructures were removed from the surface to ensure that bone response observed was dependent only on the nanotopography and/or chemistry of the surface. Early in vivo bone response (4 weeks) evaluation was investigated in a rabbit model. Results: In the present study, nano titania coated implants showed an increased coverage area and feature density, forming a homogenous layer compared to nano HA implants. Bone response observed at 4 weeks could not be explained by the surface chemistry. New formed bone connected to the original cortical bone demonstrated an increase of 24% for the nano titania compared to the nano HA implant, although the difference was not statistically significant. Conclusion: Thus, no evidence of enhanced bone formation to nano hydroxyapatite modified implants was observed compared to nano titania modified implants. The presence of specific nano structures; dependent on the surface modification exhibiting different size and distribution did modulate in vivo bone response.
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| 2. |
- Wennerberg, Ann, 1955, et al.
(författare)
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Nanoporous TiO(3) Thin Film on Titanium Oral Implants for Enhanced Human Soft Tissue Adhesion: A Light and Electron Microscopy Study.
- 2011
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Ingår i: Clinical implant dentistry and related research. - : Wiley. - 1708-8208 .- 1523-0899.
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT Background: Previous experimental studies have demonstrated direct soft tissue attachment for nanoporous titanium dioxide (TiO(2)) thin film on implants, while implants without TiO(2) thin film have not shown this capability. Purpose: The aims were to evaluate and compare TiO(2) surface-modified experimental microimplants with unmodified microimplants with respect to tissue interaction of the human oral mucosa evaluated by light microscopy on ground sections and semithin sections and transmission electron microscopy on ultrathin sections, and to characterize the inflammatory response and the level of the marginal bone resorption. Materials and Methods: The study was a single-center, randomized, comparative, clinical investigation with intrasubject comparison of implants with and without TiO(2) thin film in 15 patients. Results: Two comparator microimplants showed mild erythema and expulsion of fluids. The surrounding tissues around all test implants were clinically healthy. The oral mucosa in contact with the abutment part of the microimplant was 72% for the test implants and 48% for the comparator implants, a statistically significant difference (p = .0268). No statistically significant difference was found in other histological variables. The marginal bone loss in 14 weeks was 0.5 mm for the stable test (n = 11) and 1.7 mm for the stable comparator implants (n = 9; p = .0248). Conclusions: The nanoporous TiO(2) surface modification has potential clinical benefits because of increased adherence of soft tissue and possible reduced bone resorption.
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