| 1. |
|
|
| 2. |
- Bergh, Anders, et al.
(författare)
-
Carbohydrate functionalization using cationic iron carbonyl complexes
- 2008
-
Ingår i: Carbohydrate Research. - : Elsevier BV. - 1873-426X .- 0008-6215. ; 343:10-11, s. 1808-1813
-
Tidskriftsartikel (refereegranskat)abstract
- Cationic iron carbonyl cyclohexadiene complexes were employed in the derivatization of the 3-OH position of unprotected and protected methyl beta-D-galactopyranosides using two different approaches, giving access to galactopyranosides with an aromatic or cyclohexadienoic functionality in this position. (c) 2008 Elsevier Ltd. All rights reserved.
|
|
| 3. |
- Bergh, Anders, et al.
(författare)
-
Cobalt-mediated solid phase synthesis of 3-O-alkynylbenzyl galactosides and their evaluation as galectin inhibitors
- 2006
-
Ingår i: Tetrahedron. - : Elsevier BV. - 0040-4020. ; 62:35, s. 8309-8317
-
Tidskriftsartikel (refereegranskat)abstract
- Methyl beta-D-galactoside was converted to the corresponding 3,4-O-stannylene acetal, which was selectively benzylated with 3-iodobenzyl bromide and coupled to a polymer-bound propargylic ether via a Sonogashira reaction. The polymer-bound carbohydrate substrate was cleaved from the resin with different carbon nucleophiles in a cobalt-mediated Nicholas reaction. The product 3-O-alkynylbenzyl galactosides were screened towards galectin-1, -3, -7, -8N and -9N in a competitive fluorescence polarisation assay. Particularly potent inhibitors were identified against galectin-7 with affinity enhancements up to one order of magnitude due to the 3-O-alkynylbenzyl moiety. (c) 2006 Elsevier Ltd. All rights reserved.
|
|
| 4. |
- Bromfield, Karen M., 1976, et al.
(författare)
-
An iron carbonyl approach to the influenza neuraminidase inhibitor oseltamivir
- 2007
-
Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1364-548X .- 1359-7345. ; :30, s. 3183-3185
-
Tidskriftsartikel (refereegranskat)abstract
- A novel synthetic route towards oseltamivir, an influenza neuraminidase inhibitor, has been achieved employing a cationic iron carbonyl complex, providing an alternate pathway with the potential to access diverse analogues.
|
|
| 5. |
- Bromfield, Karen M., 1976, et al.
(författare)
-
Synthetic applications of cationic iron and cobalt carbonyl complexes
- 2009
-
Ingår i: Dalton Transactions. - 1477-9226 .- 1477-9234. ; :26, s. 5051-5061
-
Tidskriftsartikel (refereegranskat)abstract
- Metal carbonyl stabilized cationic species react with a wide range of nucleophiles under mild conditions, and have thus found many synthetic applications. In this Perspective, we describe the utility of iron carbonyl dienyl cations in solution and solid phase parallel synthesis, and in the development of a new synthetic route towards oseltamivir phosphate (Tamiflu). We also discuss the solid phase version of the Nicholas reaction, employing cobalt carbonyl stabilized propargylic cations, and giving access to substituted alkynes.
|
|
| 6. |
- Dolhem, Franck, 1975, et al.
(författare)
-
Modular synthesis of ChiraClick ligands: A library of P-chirogenic phosphines
- 2007
-
Ingår i: Journal of Combinatorial Chemistry. - : American Chemical Society (ACS). - 1520-4774 .- 1520-4766. ; 9:3, s. 477-486
-
Tidskriftsartikel (refereegranskat)abstract
- A library of novel and diverse P-chirogenic phosphine ligands containing a triazole moiety (ChiraClick ligands) were prepared in high yield in a modular fashion that allows for variation of both the phosphine and the triazole structure, as well as giving access to the two enantiomers of the ligand.
|
|
| 7. |
|
|
| 8. |
- Dunås, Petter, 1990, et al.
(författare)
-
Azulene functionalization by iron-mediated addition to a cyclohexadiene scaffold
- 2020
-
Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 85:21, s. 13453-16465
-
Tidskriftsartikel (refereegranskat)abstract
- The functionalization of azulenes via reaction with cationic η5-iron carbonyl diene complexes under mild reaction conditions is demonstrated. A range of azulenes, including derivatives of naturally occurring guaiazulene, were investigated in reactions with three electrophilic iron complexes of varying electronic properties, affording the desired coupling products in 43−98% yield. The products were examined with UV− vis/fluorescence spectroscopy and showed interesting halochromic properties. Decomplexation and further derivatization of the products provide access to several different classes of 1-substituted azulenes, including a conjugated ketone and a fused tetracycle.
|
|
| 9. |
|
|
| 10. |
- Dunås, Petter, 1990, et al.
(författare)
-
Palladium-catalyzed stereoselective domino arylation-acylation: an entry to chiral tetrahydrofluorenone scaffolds
- 2021
-
Ingår i: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1364-548X .- 1359-7345. ; 57:53, s. 6518-6521
-
Tidskriftsartikel (refereegranskat)abstract
- A palladium-catalyzed domino arylation-cyclization of biocatalytically derived cyclic 1,3-dienes is demonstrated. The reaction introduces a high degree of structural complexity in a single step, giving access to tricyclic tetrahydrofluorenones with full regio- and stereoselectivity. The transformation proceeds through a novel acylation-terminated Heck-type sequence, and quantum chemical calculations indicate that C-H activation is involved in the terminating acylation step.
|
|
