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Sökning: WFRF:(Karagianni N.)

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  • Kumari, S., et al. (författare)
  • Tumor Necrosis Factor Receptor Signaling in Keratinocytes Triggers Interleukin-24-Dependent Psoriasis-like Skin Inflammation in Mice
  • 2013
  • Ingår i: Immunity. - 1074-7613 .- 1097-4180. ; 5:39, s. 899-911
  • Tidskriftsartikel (refereegranskat)abstract
    • Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays an essential role in the pathogenesis of psoriasis, but its mechanism of action remains poorly understood. Here we report that the development of psoriasis-like skin inflammation in mice with epidermis-specific inhibition of the transcription factor NF-κB was triggered by TNF receptor 1 (TNFR1)-dependent upregulation of interleukin-24 (IL-24) and activation of signal transducer and activator of transcription 3 (STAT3) signaling in keratinocytes. IL-24 was strongly expressed in human psoriatic epidermis, and pharmacological inhibition of NF-κB increased IL-24 expression in TNF-stimulated human primary keratinocytes, suggesting that this mechanism is relevant for human psoriasis. Therefore, our results expand current views on psoriasis pathogenesis by revealing a new keratinocyte-intrinsic mechanism that links TNFR1, NF-κB, ERK, IL-24, IL-22R1, and STAT3 signaling to disease initiation.
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  • Papawassiliou, Wassilios, 1991-, et al. (författare)
  • Detection of Weyl fermions and the metal to Weyl-semimetal phase transition in WTe2via broadband high resolution NMR
  • 2022
  • Ingår i: Physical Review Research. - 2643-1564. ; 4:3
  • Tidskriftsartikel (refereegranskat)abstract
    • Weyl fermions (WFs) in the type-II Weyl semimetal (WSM) WTe2 are difficult to resolve experimentally because the Weyl bands disperse in an extremely narrow region of the (E−k) space. Here, by using DFT-assisted high-resolution 125Te solid-state nuclear magnetic resonance (ssNMR) in the temperature range 50–700 K, we succeeded in detecting low energy WF excitations and monitoring their evolution with temperature. Remarkably, WFs are observed to emerge at T∼120 K, while at lower temperatures WTe2 behaves as a trivial metal. This intriguing phenomenon is induced by the rapid raise of the Fermi level upon heating, which crosses the Weyl bands only for T>120 K. The abrupt change of the NMR parameters at this temperature is signature of a topological Lifshitz transition instead of a cursive energy-bands crossing.
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  • Resultat 1-4 av 4

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