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- Akdis, M, et al.
(författare)
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Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
- 2004
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Ingår i: Journal of Experimental Medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 199:11, s. 1567-1575
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Tidskriftsartikel (refereegranskat)abstract
- The mechanisms by which immune responses to nonpathogenic environmental antigens lead to either allergy or nonharmful immunity are unknown. Single allergen-specific T cells constitute a very small fraction of the whole CD4(+) T cell repertoire and can be isolated from the peripheral blood of humans according to their cytokine profile. Freshly purified interferon-gamma-, interleukin (IL)-4-, and IL-10-producing allergen-specific CD4(+) T cells display characteristics of T helper cell (Th)1-, Th2, and T regulatory (Tr)1-like cells, respectively. Tr1 cells consistently represent the dominant subset specific for common environmental allergens in healthy individuals; in contrast, there is a high frequency of allergen-specific IL-4-secreting T cells in allergic individuals. Tr1 cells use multiple suppressive mechanisms, IL-10 and TGF-beta as secreted cytokines, and cytotoxic T lymphocyte antigen 4 and programmed death 1 as surface molecules. Healthy and allergic individuals exhibit all three allergen-specific subsets in different proportions, indicating that a change in the dominant subset may lead to allergy development or recovery. Accordingly, blocking the suppressor activity of Tr1 cells or increasing Th2 cell frequency enhances allergen-specific Th2 cell activation ex vivo. These results indicate that the balance between allergen-specific Tr1 cells and Th2 cells may be decisive in the development of allergy.
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| 3. |
- Grasselli, Giacomo, et al.
(författare)
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ESICM guidelines on acute respiratory distress syndrome : definition, phenotyping and respiratory support strategies
- 2023
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Ingår i: Intensive Care Medicine. - : Springer Nature. - 0342-4642 .- 1432-1238. ; 49, s. 727-759
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Tidskriftsartikel (refereegranskat)abstract
- The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM. The review was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. We followed the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess the certainty of evidence and grade recommendations and the quality of reporting of each study based on the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network guidelines. The CPG addressed 21 questions and formulates 21 recommendations on the following domains: (1) definition; (2) phenotyping, and respiratory support strategies including (3) high-flow nasal cannula oxygen (HFNO); (4) non-invasive ventilation (NIV); (5) tidal volume setting; (6) positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM); (7) prone positioning; (8) neuromuscular blockade, and (9) extracorporeal life support (ECLS). In addition, the CPG includes expert opinion on clinical practice and identifies the areas of future research.
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| 5. |
- Assimonis, Stylianos D., et al.
(författare)
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Improved parametric families of intersymbol interference-free Nyquist pulses using inner and outer functions
- 2011
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Ingår i: IET Signal Processing. - : Institution of Engineering and Technology (IET). - 1751-9675 .- 1751-9683. ; 5:2, s. 157-163
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Tidskriftsartikel (refereegranskat)abstract
- In this article, the authors introduce and study the performance of two novel parametric families of Nyquist intersymbol interference-free pulses. Using only two design parameters, the proposed pulses yield an enhanced performance compared to the sophisticated flipped-inverse hyperbolic secant (asech) filter, which was recently documented in the literature. Although the construction of parametric families originates from the work of Beaulieu and Damen, the authors' approach is based on the concept of ‘inner’ and ‘outer’ functions and for this reason a higher flexibility in the choice of the family members is achieved. The proposed pulses may decay slower than the original raised-cosine (RC) pulse outside the pulse interval, but exhibit a more pronounced decrease in the amplitudes of the two largest sidelobes and this accounts for their improved robustness to error probabilities. It is clearly shown, via simulation results, that a lower bit error rate (BER), compared to the existing pulses, can be achieved for different values of the roll-off factor and timing jitter. Moreover, a smaller maximum distortion as well as a more open-eye diagram are attained which further demonstrate the superiority of the proposed pulse shaping filters.
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| 9. |
- Matthaiou, Michail, 1981, et al.
(författare)
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Mutual information statistics and beamforming performance analysis of optimized LoS MIMO systems
- 2010
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Ingår i: IEEE Transactions on Communications. - 1558-0857. ; 58:11, s. 3316-3329
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Tidskriftsartikel (refereegranskat)abstract
- This paper provides a systematic mutual information(MI) and multichannel beamforming (MBF) characterizationof optimized multiple-input multiple-output (MIMO) communication systems operating in Ricean fading. These optimized configurations are of high practical importance since, contrary to the common belief, benefit from the presence of direct Line-of-Sight (LoS) components and deliver maximum multiplexing gains, by deploying specifically designed antenna arrays at bothends. In the following, using elements from random matrixtheory, novel analytical expressions are derived for the exact and asymptotic MI statistics while the prevalent Gaussian approximation is examined. Moreover, new explicit expressions for the marginal eigenvalues are deduced which are thereafter used to analyze the BF performance of the associated eigenmodes in terms of Signal-to-Noise ratio (SNR) outage probability. We note that all derived formulas are given in tractable determinant formand therefore allow for fast and efficient computation and also yield an excellent match with Monte-Carlo simulations, under different fading scenarios and model parameters.
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| 10. |
- Matthaiou, Michail, 1981, et al.
(författare)
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On the capacity of generalized-K fading MIMO channels
- 2010
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Ingår i: IEEE Transactions on Signal Processing. - 1941-0476 .- 1053-587X. ; 58:11, s. 5939-5944
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Tidskriftsartikel (refereegranskat)abstract
- This correspondence explores the ergodic capacity of multiple-input multiple-output (MIMO) systems operating in generalized-K fading conditions. Using some recent results on majorization theory, we derive an analytical capacity bound which is applicable for arbitrary values of the signal-to-noise ratio (SNR) and number of antenna elements.In addition, we deduce simple bound approximations in the high-SNR regime and demonstrate that the effects of small and large-scale fading are decoupled. A similar statistical analysis is carried out for MIMO channelsunder K-fading, which represents a special case of generalized- fading that can be tackled via the Wishart matrix theory. The implications of the model parameters on the bound performance are also investigated viaMonte Carlo simulations.
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