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- Holm, Sten, 1948, et al.
(författare)
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Experimental disc degeneration due to endplate injury
- 2004
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Ingår i: J Spinal Disord Tech. - 1536-0652. ; 17:1, s. 64-71
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to create an experimental model of disc degeneration that closely mimicked human disc degeneration. In six domestic pigs, an L4 cranial endplate perforation into the nucleus pulposus was made. Three months postoperatively, compressive testing was performed on the L2-L4 motion segments, and intradiscal pressure was measured in the intervening discs. Histochemical and morphologic examinations were made on the excised degenerated and adjacent discs. A significant reduction in water content was observed in the outer anterior annulus of the degenerated disc. In the nucleus, the proteoglycan content was significantly reduced, as well as the cellularity, although not significantly. The nucleus lost its gel-like structure and was discolored, and there was delamination of annular layers. Intradiscal pressure in the nucleus was significantly lower in the degenerated disc. In conclusion, experimental degeneration of the intervertebral disc induced by endplate penetration resembled human disc degeneration, as exemplified by biochemical and structural changes.
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- Karladani, Abbas, 1954, et al.
(författare)
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Ankle arthrodesis using dowel bone graft and cancellous-bone screws: a mechanical study in cadavers
- 2004
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Ingår i: Acta Orthop Scand. - 0001-6470. ; 75:4, s. 471-6
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: There are numerous techniques for ankle arthrodesis. MATERIAL AND METHODS: We studied the stability of an ankle arthrodesis with the use of two cross-screws combined with dowel graft technique in 14 fresh-frozen ankles from amputees. The arthrodesis was performed by a dowel graft technique, in the coronal plane in 7 specimens (group 1) and in the diagonal plane in the remaining 7 (group 2). Allocation into the two groups took place after normalization according to the bone mineral content of the specimens. All ankles were fixed with two 6.5-mm diameter cancellous-bone screws, with the ankle in neutral position. Tibiotalar motion was measured during 5 Nm torque loading in plantar flexion-dorsiflexion, abduction-adduction and eversion-inversion planes of the ankle joint. Two testing sequences were performed and the mean value of both tests in each direction was used for the analysis. RESULTS: In all 3 planes, the torque applied caused more motion with the dowel graft in the coronal plane (group 1) than with the graft in the diagonal plane (group 2). The differences between the two groups were significant for abduction-adduction and eversion-inversion planes. Statistical analysis of differences between the first and second test showed significantly greater stiffness in group 2 than in group 1 in plantar flexion-dorsiflexion torque. INTERPRETATION: The placement of a dowel graft in the diagonal plane in comparison to the coronal plane significantly increased the initial stability of an ankle arthrodesis.
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- Karladani, Abbas, 1954
(författare)
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On the treatment of tibial shaft fractures
- 2001
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this thesis was to evaluate those factors, which have predictive value for development of complications after tibial shaft fractures, and to evaluate the outcome of the available treatment methods for closed, as well as open tibial shaft fractures associated with extensive soft-tissue injury. To determine the factors, which influence healing speed, we reviewed 100 consecutive patients with 104 tibial shaft fractures tibial shaft fractures. The results showed that the relative risk of developing nonunion in open fractures was 8.2 and in fractures exposed to high-energy trauma was 2.9. We conducted a prospective study of 53 unilateral, displaced and closed or type I open tibial shaft fractures, who were randomized by technique of minimization in two treatment groups, 27 patients in the nailed group and 26 patients in the cast group. All patients were assessed for union, and complications were documented. All patients completed the Nottingham Health Profile questionnaire. They also assessed their pain intensity at rest and during walking on visual analogue scales. 27 of these patients entered into study III for assessment of the recovery of the injured limb. Using force platform and dynamometer, balance (as center of pressure) and muscle strength (as torque of the knee joint during knee extension) were measured, respectively. The results showed that treatment of displaced closed or type I open tibial fractures with intramedullary nailing is superior to cast/ brace treatment as regards early complication and recovery of limb function 1 year after healed fracture. A retrospective review of 18 consecutive patients with salvaged tibial shaft fractures associated with extensive soft-tissue damage was undertaken to evaluate bio-psycho-social function of the outcome. All patients were assessed for their physical function, psychological status and general function. The results demonstrated that the patients had obvious physical disability. However, non-depressive patients were generally satisfied with the outcome of salvage procedure. A retrospective review was conducted on consecutive 9 patients with tibial shaft fractures and extensive soft tissue damage, who had completed treatment by means of bone resection and distraction. All patients were treated by debridement of devitalized soft tissue and resection of dead bone at the fracture site. The median bone shortening was 4 (3-9) cm. There were no deep infections or nonunions and no secondary amputations. Bone debridement and limb lengthening, with multidisciplinary approach, is often successful in salvaging limbs that otherwise would have been at high risk for amputation.
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- Paydar, S., et al.
(författare)
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A Comparison of the Effects of Topical Prolavacid Solution (a Polyhexamethylene Biguanide-Based Wound Cleanser) and Medihoney Ointment in a Rat Model of Cutaneous Wound
- 2017
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Ingår i: Advances in Wound Care. - : Mary Ann Liebert Inc. - 2162-1918 .- 2162-1934. ; 6:12, s. 407-412
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This experimental work examined the healing effect and probable adverse impact of topical Prolavacid (R) solution (a polyhexamethylene biguanide-based wound cleanser) and topical Medihoney ointment in an animal model of cutaneous wound. Approach: We randomly divided 22 adult Sprague-Dawley rats (all were male) in two groups (n=11): (1) those for which Prolavacid solution was poured on the skin wound surface; and (2) those animals for which Medihoney (R) ointment was applied to the wounds. These two agents were applied daily throughout the study period (21 days). We photographically followed the wounds' contraction with imaging performed on days 0, 7, and 21 postwounding. The histopathologic features of the healing wounds were evaluated using skin biopsies taken on days 7 and 21 postwounding. Results: The difference in mean wound surface area between two groups was not statistically significant on the examined days. Histopathological assessment indicated no statistically significant difference between the Prolavacid- and Medihoney-treated groups on days 7 and 21. We did not detect tissue necrosis following the topical application of Prolavacid solution. Innovation: This was the first study to examine the efficacy and probable adverse consequences of topical Prolavacid on cutaneous wound healing process. Conclusion: Our work showed no statistically significant difference between the efficacy of daily topical application of Prolavacid and Medihoney products on the healing process of fresh cutaneous wounds in our rat model.
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