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- Dellve, Lotta, 1965, et al.
(författare)
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Macro-organizational factors, the incidence of work disability, and work ability among the total workforce of home care workers in Sweden.
- 2006
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Ingår i: Scandinavian journal of public health. - : SAGE Publications. - 1403-4948 .- 1651-1905. ; 34:1, s. 17-25
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: To investigate the importance of macro-organizational factors, i.e. organizational sociodemographic and socioeconomic preconditions, of the municipal incidence of long-term sick leave, disability pension, and prevalence of workers with long-term work ability among home care workers. METHODS: In an ecological study design, data from national databases were combined by record linkage. Descriptive and analytical statistics were used to estimate and interpret macro-organizational factors (economic resources, region, unemployment, employment, occupational rehabilitation, return to work, age structures of inhabitants and home care workers). RESULTS: The incidence of long-term sick leave among female home care workers was twice as high as that of male home care workers, and incidence of disability pension was about four times as high for the women. A great variation in municipal incidence of long-term sick leave, disability pension, and long-term work ability (101-264, 0.6-19.6, and 913-1,279 per 1,000 full-time equivalent workers and year) was also found. The strongest single factor for long-term work ability was a high proportion of part-time or hourly paid employees, which explained 35% of the municipal variation. Macro-organizational factors explained long-term work ability (47-62% explained variance) better than long-term sick leave (33% explained variance). There was a low rehabilitation activity; only 2% received occupational rehabilitation and 5% of those on sick leave longer than 2 weeks returned to work within 30 days. CONCLUSIONS: The differences in the municipal proportion of work ability incidence indicate a preventive potential, especially related to employment and return to work after sick leave.
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- Eriksson, Mats, 1959-, et al.
(författare)
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Life Stage qnd Cross-Population Nursing Research : From Evidence to Application
- 2024
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Ingår i: CARE4 2024. - : CARE4 2024.
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Konferensbidrag (refereegranskat)abstract
- Örebro University has embarked on a strategic endeavor to establish a robust international nursing research environment encompassing all stages of life and types of healthcare. Our commitment spans from the care of preterm infants, children, and adolescents, to adults, the elderly, and various healthcare settings, including health promotion, general nursing, prehospital care, intensive care, and perioperative nursing.In this symposium, our primary objective is to showcase selected areas of our research and underscore their collective contribution to the development of sustainable and robust nursing research with a significant international impact on healthcare. Through focused presentations, we will highlight research findings within two distinct age groups: newborn infants and adults and elderly individuals. Furthermore, we will explore the role of evidence-based nursing practice and its profound influence on patient care. Lastly, we will summarize how our research translates into clinical implications, our efforts in fostering international outreach, and outline our future trajectory as an integral part of the new European University alliance, NEOLAiA.
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- Gutkin, Renaud, et al.
(författare)
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Slutrapport för det koncernstrategiska projektet Swerea Virtual Lab
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Simulering som verktyg för utveckling, tillverkning och provning av produkter i avancerade material är en stor och betydande del av Swereas ordinarie verksamhet. Swerea Virtual Lab är ett fokusområde inom Swerea AB. Swerea Virtual Lab är en kraftsamling för att hjälpa industrin att utöka sin virtuella produktutveckling. Swerea Virtual Lab är en unik samarbetspartner genom sin storlek, kompetens, materialbredd och förmåga att generera indata till beräkningsmodell, genomföra simuleringar och verifiera resultat i laboratorieskala. Swerea Virtual Lab är ett välkänt begrepp, en prioriterad samarbetspartner och den självklara forskningspartnern i EU projekt och i industriella utvecklingsprojekt i Europa och Sverige. Swerea Virtual Lab kännetecknas av tydlig kontaktstruktur, transparent process, hög kvalité och hög leveranssäkerhet. Swerea Virtual Lab vänder sig till alla branscher som har ett intresse av virtuell produktutveckling.
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- Hansson, Mattias, et al.
(författare)
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Amino acid residues His183 and Glu264 in Bacillus subtilis ferrochelatase direct and facilitate the insertion of metal ion into protoporphyrin IX
- 2007
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Ingår i: Biochemistry. - : American Chemical Society (ACS). - 0006-2960 .- 1520-4995. ; 46:1, s. 87-94
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Tidskriftsartikel (refereegranskat)abstract
- Ferrochelatase catalyzes the terminal step in the heme biosynthetic pathway, i.e., the incorporation of Fe(II) into protoporphyrin IX. Various biochemical and biophysical methods have been used to probe the enzyme for metal binding residues and the location of the active site. However, the location of the metal binding site and the path of the metal into the porphyrin are still disputed. Using site-directed mutagenesis on Bacillus subtilis ferrochelatase we demonstrate that exchange of the conserved residues His183 and Glu264 affects the metal affinity of the enzyme. We also present the first X-ray crystal structure of ferrochelatase with iron. Only a single iron was found in the active site, coordinated in a square pyramidal fashion by two amino acid residues, His183 and Glu264, and three water molecules. This iron was not present in the structure of a His183Ala modified ferrochelatase. The results strongly suggest that the insertion of a metal ion into protoporphyrin IX by ferrochelatase occurs from a metal binding site represented by His183 and Glu264.
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- Hansson, Mattias, et al.
(författare)
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Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase.
- 2011
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Ingår i: Journal of Biological Inorganic Chemistry. - : Springer Science and Business Media LLC. - 1432-1327 .- 0949-8257. ; 16:2, s. 235-242
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Tidskriftsartikel (refereegranskat)abstract
- Ferrochelatase catalyzes the insertion of Fe(2+) into protoporphyrin IX. The enzymatic product heme (protoheme IX) is a well-known cofactor in a wide range of proteins. The insertion of metal ions other than Fe(2+) occurs rarely in vivo, but all ferrochelatases that have been studied can insert Zn(2+) at a good rate in vitro. Co(2+), but not Cu(2+), is known to be a good substrate of the mammalian and Saccharomyces cerevisiae ferrochelatases. In contrast, Cu(2+), but not Co(2+), has been found to be a good substrate of bacterial Bacillus subtilis ferrochelatase. It is not known how ferrochelatase discriminates between different metal ion substrates. Structural analysis of B. subtilis ferrochelatase has shown that Tyr13 is an indirect ligand of Fe(2+) and a direct ligand of a copper mesoporphyrin product. A structure-based comparison revealed that Tyr13 aligns with a Met residue in the S. cerevisiae and human ferrochelatases. Tyr13 was changed to Met in the B. subtilis enzyme by site-directed mutagenesis. Enzymatic measurements showed that the modified enzyme inserted Co(2+) at a higher rate than the wild-type B. subtilis ferrochelatase, but it had lost the ability to use Cu(2+) as a substrate. Thus, the B. subtilis Tyr13Met ferrochelatase showed the same metal specificity as that of the ferrochelatases from S. cerevisiae and human.
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