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Träfflista för sökning "WFRF:(Karlson S.) "

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Numrering	Referens	Omslagsbild	Hitta
1.	Kanai, M, et al. (författare) 2023 swepub:Mat__t
2.	Niemi, MEK, et al. (författare) 2021 swepub:Mat__t
3.	Pathak, GA, et al. (författare) A first update on mapping the human genetic architecture of COVID-19 2022 Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 608:7921, s. E1-E10 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
4.	Mosley, Jonathan D., et al. (författare) Probing the Virtual Proteome to Identify Novel Disease Biomarkers 2018 Ingår i: Circulation. - 1524-4539. ; 138:22, s. 2469-2481 Tidskriftsartikel (refereegranskat)abstract BACKGROUND: Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical barriers and costs of implementing such assays at scale. To overcome these challenges, we used a "virtual proteomic" approach, linking genetically predicted protein levels to clinical diagnoses in >40 000 individuals. METHODS: We used genome-wide association data from the Framingham Heart Study (n=759) to construct genetic predictors for 1129 plasma protein levels. We validated the genetic predictors for 268 proteins and used them to compute predicted protein levels in 41 288 genotyped individuals in the Electronic Medical Records and Genomics (eMERGE) cohort. We tested associations for each predicted protein with 1128 clinical phenotypes. Lead associations were validated with directly measured protein levels and either low-density lipoprotein cholesterol or subclinical atherosclerosis in the MDCS (Malmö Diet and Cancer Study; n=651). RESULTS: In the virtual proteomic analysis in eMERGE, 55 proteins were associated with 89 distinct diagnoses at a false discovery rate q<0.1. Among these, 13 associations involved lipid (n=7) or atherosclerosis (n=6) phenotypes. We tested each association for validation in MDCS using directly measured protein levels. At Bonferroni-adjusted significance thresholds, levels of apolipoprotein E isoforms were associated with hyperlipidemia, and circulating C-type lectin domain family 1 member B and platelet-derived growth factor receptor-β predicted subclinical atherosclerosis. Odds ratios for carotid atherosclerosis were 1.31 (95% CI, 1.08-1.58; P=0.006) per 1-SD increment in C-type lectin domain family 1 member B and 0.79 (0.66-0.94; P=0.008) per 1-SD increment in platelet-derived growth factor receptor-β. CONCLUSIONS: We demonstrate a biomarker discovery paradigm to identify candidate biomarkers of cardiovascular and other diseases.
5.	Oprea, Tudor I, et al. (författare) Unexplored therapeutic opportunities in the human genome 2018 Ingår i: Nature Reviews Drug Discovery. - : Springer Science and Business Media LLC. - 1474-1776 .- 1474-1784. ; 17:5, s. 317-332 Tidskriftsartikel (refereegranskat)abstract A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately one out of three proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.
6.	Cui, J, et al. (författare) Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis 2013 Ingår i: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 9:3, s. e1003394- Tidskriftsartikel (refereegranskat)
7.	Cui, J, et al. (författare) Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy 2010 Ingår i: Arthritis and rheumatism. - : Wiley. - 1529-0131 .- 0004-3591. ; 62:7, s. 1849-1861 Tidskriftsartikel (refereegranskat)
8.	Meister, Mikael, 1969, et al. (författare) High-energy breakup of 8B 2003 Ingår i: Nucl. Phys. A. ; 718, s. 431-433 Konferensbidrag (refereegranskat)
9.	Raychaudhuri, S, et al. (författare) Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk 2009 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:12, s. 1313-U76 Tidskriftsartikel (refereegranskat)
10.	Stahl, EA, et al. (författare) Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci 2010 Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:6, s. 508-U56 Tidskriftsartikel (refereegranskat)

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Typ av publikation: tidskriftsartikel (84); konferensbidrag (7); annan publikation (2); doktorsavhandling (2); forskningsöversikt (1)

Typ av innehåll: refereegranskat (81); övrigt vetenskapligt/konstnärligt (15)

Författare/redaktör: Karlson, EW (30); KLARESKOG, L (16); Borg-Karlson, Anna-K ... (16); Raychaudhuri, S (15); Alfredsson, L (15); Karlson, Björn W., 1 ... (14); visa fler...; Plenge, RM (13); Padyukov, L (11); Gregersen, PK (11); Costenbader, KH (11); Cui, J. (10); Lundman, P (8); Daly, MJ (8); Karlson, BW (8); Herlitz, Johan (7); Karlson, S. (7); Worthington, J (6); Lee, AT (6); Criswell, LA (6); De Vries, N (6); Ding, B. (6); Bengtsson, C (6); Toes, REM (6); Tak, PP (6); Crusius, JBA (6); Okada, Y. (5); Khan, A. (5); Huizinga, TWJ (5); Neale, BM (5); Altshuler, D. (5); Holmberg, S. (5); Malspeis, S (5); Barton, A. (5); Hartford, M (5); van der Horst-Bruins ... (5); Wolbink, GJ (5); Saevarsdottir, S (4); Amos, CI (4); Campbell, A (4); Graham, RR (4); Gustafson, Lars (4); Guiducci, C (4); Seielstad, M (4); Burtt, NP (4); Mozuraitis, Raimonda ... (4); Warkentin, Siegbert (4); Orellana, C (4); Sparks, JA (4); Stahl, EA (4); Weiss, ST (4); visa färre...

Lärosäte: Karolinska Institutet (48); Göteborgs universitet (17); Kungliga Tekniska Högskolan (16); Uppsala universitet (11); Lunds universitet (10); Stockholms universitet (9); visa fler...; Högskolan i Borås (7); Linnéuniversitetet (6); Sveriges Lantbruksuniversitet (3); Umeå universitet (2); Chalmers tekniska högskola (2); Örebro universitet (1); Linköpings universitet (1); Mittuniversitetet (1); visa färre...

Språk: Engelska (98)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (26); Naturvetenskap (22); Teknik (1); Lantbruksvetenskap (1)

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