| 1. |
- Delling, Lotta, et al.
(författare)
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Feasibility of bariatric surgery as a strategy for secondary prevention in cardiovascular disease: a report from the Swedish obese subjects trial.
- 2010
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Ingår i: Journal of obesity (Online). - : Hindawi Limited. - 2090-0716 .- 2090-0708. ; 2010
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Forskningsöversikt (refereegranskat)abstract
- Aims. Evaluation of bariatric surgery as secondary prevention in obese patients with ischemic heart disease (IHD). Methods. Analysis of data from 4047 subjects in the Swedish Obese Subjects (SOSs) study. Thirty-five patients with IHD are treated with bariatric surgery (n = 21) or conventional treatment (n = 14). Mean follow-up is 10.8 years. Results. Bariatric surgery resulted in sustained weight loss during the study period. After 2 years, the surgery group displayed significant reductions in cardiovascular risk factors, relief from cardiorespiratory symptoms, increments in physical activity, and improved quality of life. After 10 years, recovery from hypertension, diabetes, physical inactivity, and depression was still more common in the surgery group. There were no signs of increased cardiovascular morbidity or mortality in the surgery group. Conclusion. Bariatric surgery appears to be a safe and feasible treatment to achieve long-term weight loss and improvement in cardiovascular risk factors, symptoms, and quality of life in obese subjects with IHD.
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| 2. |
- Rådegran, Göran, et al.
(författare)
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Characteristics and survival of adult Swedish PAH and CTEPH patients 2000-2014
- 2016
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Ingår i: Scandinavian Cardiovascular Journal. - : Taylor & Francis. - 1401-7431 .- 1651-2006. ; 50:4, s. 243-250
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The Swedish Pulmonary Arterial Hypertension Register (SPAHR) is an open continuous register, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) patients from 2000 and onwards. We hereby launch the first data from SPAHR, defining baseline characteristics and survival of Swedish PAH and CTEPH patients.DESIGN: Incident PAH and CTEPH patients 2008-2014 from all seven Swedish PAH-centres were specifically reviewed.RESULTS: There were 457 PAH (median age: 67 years, 64% female) and 183 CTEPH (median age: 70 years, 50% female) patients, whereof 77 and 81%, respectively, were in functional class III-IV at diagnosis. Systemic hypertension, diabetes, ischaemic heart disease and atrial fibrillation were common comorbidities, particularly in those >65 years. One-, 3- and 5-year survival was 85%, 71% and 59% for PAH patients. Corresponding numbers for CTEPH patients with versus without pulmonary endarterectomy were 96%, 89% and 86% versus 91%, 75% and 69%, respectively. In 2014, the incidence of IPAH/HPAH, associated PAH and CTEPH was 5, 3 and 2 per million inhabitants and year, and the prevalence was 25, 24 and 19 per million inhabitants.CONCLUSION: The majority of the PAH and CTEPH patients were diagnosed at age >65 years, in functional class III-IV, and exhibiting several comorbidities. PAH survival in SPAHR was similar to other registers.
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| 3. |
- Ameur, Adam, et al.
(författare)
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SweGen : a whole-genome data resource of genetic variability in a cross-section of the Swedish population
- 2017
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Ingår i: European Journal of Human Genetics. - : NATURE PUBLISHING GROUP. - 1018-4813 .- 1476-5438. ; 25:11, s. 1253-1260
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Tidskriftsartikel (refereegranskat)abstract
- Here we describe the SweGen data set, a comprehensive map of genetic variation in the Swedish population. These data represent a basic resource for clinical genetics laboratories as well as for sequencing-based association studies by providing information on genetic variant frequencies in a cohort that is well matched to national patient cohorts. To select samples for this study, we first examined the genetic structure of the Swedish population using high-density SNP-array data from a nation-wide cohort of over 10 000 Swedish-born individuals included in the Swedish Twin Registry. A total of 1000 individuals, reflecting a cross-section of the population and capturing the main genetic structure, were selected for whole-genome sequencing. Analysis pipelines were developed for automated alignment, variant calling and quality control of the sequencing data. This resulted in a genome-wide collection of aggregated variant frequencies in the Swedish population that we have made available to the scientific community through the website https://swefreq.nbis.se. A total of 29.2 million single-nucleotide variants and 3.8 million indels were detected in the 1000 samples, with 9.9 million of these variants not present in current databases. Each sample contributed with an average of 7199 individual-specific variants. In addition, an average of 8645 larger structural variants (SVs) were detected per individual, and we demonstrate that the population frequencies of these SVs can be used for efficient filtering analyses. Finally, our results show that the genetic diversity within Sweden is substantial compared with the diversity among continental European populations, underscoring the relevance of establishing a local reference data set.
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| 4. |
- Aspegren Kendall, Sally, 1950-, et al.
(författare)
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The effect of a session of exercise of moderate intensity level on pressure pain thresholds in healthy women
- 2003
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Ingår i: Advances in Physiotherapy. - : Informa UK Limited. - 1403-8196 .- 1651-1948. ; 5:1, s. 15-20
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this investigation was to study in healthy women the effect of a moderately intensive physical exercise session on the pressure pain thresholds of tendon, bone and muscle. Twenty-four healthy women in the 7-14th day of the menstruation cycle took part in a 60-min exercise class. Pressure pain thresholds were measured by electronic algometer at four points before and after the class. Habitual exercise habits and perceived class exercise intensity were recorded. There was no change in pressure pain sensitivity at any site. Increased pressure pain thresholds tended to be linked to older age and later day in the follicular phase of the menstrual cycle. In conclusion, a single session of moderate exercise in an exercise setting outside the healthcare system or the laboratory did not increase pressure pain thresholds at group level in healthy women.
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| 5. |
- Dahlquist, Erik, 1951-, et al.
(författare)
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A fossil fuel free Europe need new incentives and a better control to balance power production and demand
- 2011
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Ingår i: SAUPEC 2011 July 13-15 at Cape Town University, South Africa. - Cape Town : Cape Town University Press.
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Konferensbidrag (refereegranskat)abstract
- In EU27 today there is a production of approximately 1000 TWh/ electric power from nuclear and 350 TWh/y from hydro power. The solar power potential is probably around 200 TWh/y. The wind power production is approximately 100 TWh/y but with a potential of at least 1000 TWh/y. The total biomass resources available are in the range 8500-12000 TWh/y. This gives a total of 10 000 – 15 000 TWh/y, from which at least 4000 TWh/y as electric power. This can be compared to the present gross energy use in EU 27 that was 16 084 TWh 2009, and 3400 TWh/y electric power. We can also see that there is a potential to save approximately 4 200 TWh/y in households, offices, transportation and industry. The energy balance thus should be possible to obtain with only non-fossil energy resources. Another matter is the power in time and by region. The demand does not always match the production locally at each moment and this demands a robust transmission and distribution network. Therefore we need new business models making it attractive for the users to reduce the load when there is a difficulty to deliver.
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| 6. |
- Dahlquist, Erik, 1951-, et al.
(författare)
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Combined solar power and TPV
- 2011
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Ingår i: Conference proceedings WREC 2011 in Linköping, Sweden, May 8-11, 2011. - Linköping : Linköping University Press. - 9789173930703 ; , s. 1-4240
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Konferensbidrag (refereegranskat)abstract
- In this paper design for a combined TPV and solar power system for local heat and power production is discussed. PV cells are producing electricity when there is light, while TPV cells are used when it is dark. Biomass is combusted and the heat is generating photons for the TPV system. Higher combustion temperature will give higher electric output, but also stronger deterioration of the materials in the combustor. By combining PV-cells that will generate a lot of electric power summer time with TPV-cells that can generate electric power winter time, when we also normally have a higher heat demand, we can achieve a flexible local heat and power system all year round. As both systems generate DC-power, we also can see a potential to use DC components generally, e.g for charging batteries for electrical vehicles, DC-pumps, LED-lamps etc. Design criteria for the systems are discussed in this paper for a house that is principally self sufficient on energy. Both theoretical and practical obstacles are discussed, as there are a number of issues to solve before the technique can be used in ”real life”.
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| 7. |
- Regland, Björn, 1947, et al.
(författare)
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Treatment of Alzheimer's disease with clioquinol.
- 2001
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Ingår i: Dementia and geriatric cognitive disorders. - 1420-8008. ; 12:6, s. 408-14
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Tidskriftsartikel (refereegranskat)abstract
- As heavy metal ions may be implicated in the formation of senile plaques in Alzheimer-afflicted brains, treatment with clioquinol was tested in 20 patients with Alzheimer's disease. Clioquinol is a chelator that crosses the blood-brain barrier and has greater affinity for zinc and copper ions than for calcium and magnesium ions. Treatment was given for 21 days at doses of 20 mg/day to 10 patients and 80 mg/day to another 10 patients. The study was blind to the dosages but included no controls. Cerebrospinal fluid (CSF) investigations revealed a significant increase at day 7 and a decrease at day 21 in Tau protein and growth-associated protein (GAP43). These proteins are increased in Alzheimer's disease and considered as rather stable markers. The initial increase may indicate a temporary cytotoxicity to the brain and/or an increased release into the CSF from stores in the tissue, possibly from senile plaques where the proteins are accumulated. The levels of CSF-Tau protein correlated positively and significantly with the serum levels of copper and also with the serum copper/zinc ratio. Clinical ratings showed slight improvement after 3 weeks treatment with clioquinol in this open study.
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| 8. |
- Sjöström, Lars, et al.
(författare)
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Bariatric surgery and long-term cardiovascular events.
- 2012
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Ingår i: JAMA : the journal of the American Medical Association. - : American Medical Association (AMA). - 1538-3598. ; 307:1, s. 56-65
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is a risk factor for cardiovascular events. Weight loss might protect against cardiovascular events, but solid evidence is lacking.
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| 9. |
- Sjöström, Lars, et al.
(författare)
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Effects of bariatric surgery on mortality in Swedish obese subjects.
- 2007
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Ingår i: The New England journal of medicine. - 1533-4406. ; 357:8, s. 741-52
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Obesity is associated with increased mortality. Weight loss improves cardiovascular risk factors, but no prospective interventional studies have reported whether weight loss decreases overall mortality. In fact, many observational studies suggest that weight reduction is associated with increased mortality. METHODS: The prospective, controlled Swedish Obese Subjects study involved 4047 obese subjects. Of these subjects, 2010 underwent bariatric surgery (surgery group) and 2037 received conventional treatment (matched control group). We report on overall mortality during an average of 10.9 years of follow-up. At the time of the analysis (November 1, 2005), vital status was known for all but three subjects (follow-up rate, 99.9%). RESULTS: The average weight change in control subjects was less than +/-2% during the period of up to 15 years during which weights were recorded. Maximum weight losses in the surgical subgroups were observed after 1 to 2 years: gastric bypass, 32%; vertical-banded gastroplasty, 25%; and banding, 20%. After 10 years, the weight losses from baseline were stabilized at 25%, 16%, and 14%, respectively. There were 129 deaths in the control group and 101 deaths in the surgery group. The unadjusted overall hazard ratio was 0.76 in the surgery group (P=0.04), as compared with the control group, and the hazard ratio adjusted for sex, age, and risk factors was 0.71 (P=0.01). The most common causes of death were myocardial infarction (control group, 25 subjects; surgery group, 13 subjects) and cancer (control group, 47; surgery group, 29). CONCLUSIONS: Bariatric surgery for severe obesity is associated with long-term weight loss and decreased overall mortality.
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| 10. |
- Stridh, Bengt, 1957-, et al.
(författare)
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Production cost of PV electricity in Sweden
- 2013
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Ingår i: EU PVSEC Proceedings. - 3936338337 ; , s. 4718-4722
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The photovoltaic (PV) market in Sweden is small in comparison to most of the other PV markets in the European countries. However, the market is growing and about 8 MW was installed during 2012 that is 1/3 of the totally installed power. It is expected that the market will continue to grow during 2013.The PV levelized cost of electricity (LCOE) in Sweden was studied for grid connected PV systems to understand how competitive PV is on the Swedish market. It is concluded that PV production cost is still too high to be competitive in utility scale on the Nord Pool spot market without subsidies. However, for residential or commercial systems the production cost for PV electricity is today in some cases in the same order of magnitude as, or lower than, the running cost for bought electricity even without investment subsidy or electricity certificates, with the assumed parameters for estimation of LCOE. With investment subsidy the calculation improves substantially resulting in a LCOE lower than the running cost for bought electricity. To a much smaller extent an improvement of LCOE is also seen with electricity certificates.
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