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- Ahlborg, Henrik, et al.
(författare)
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Prevalence of osteoporosis and incidence of hip fracture in women--secular trends over 30 years.
- 2010
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Ingår i: BMC Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The number of hip fractures during recent decades has been reported to be increasing, partly because of an increasing proportion of elderly women in the society. However, whether changes in hip fracture annual incidence in women are attributable to secular changes in the prevalence of osteoporosis is unclear. METHODS: Bone mineral density was evaluated by single-photon absorptiometry at the distal radius in 456 women aged 50 years or above and living in the same city. The measurements were obtained by the same densitometer during three separate time periods: 1970-74 (n = 106), 1987-93 (n = 175) and 1998-1999 (n = 178), and the age-adjusted prevalence of osteoporosis in these three cohorts was calculated. Additionally, all hip fractures sustained in the target population of women aged 50 years or above between 1967 and 2001 were registered, whereupon the crude and the age-adjusted annual incidence of hip fractures were calculated. RESULTS: There was no significant difference in the age-adjusted prevalence of osteoporosis when the three cohorts were compared (P = 1.00). The crude annual incidence (per 10,000 women) of hip fracture in the target population increased by 110% from 40 in 1967 to 84 in 2001. The overall trend in the crude incidence between 1967 and 2001 was increasing (1.58 per 10,000 women per year; 95 percent confidence interval, 1.17 to 1.99), whereas the age-adjusted incidence was stable over the same period (0.22 per 10,000 women per year; 95 percent confidence interval, -0.16 to 0.60). CONCLUSIONS: The increased number of hip fracture in elderly women is more likely to be attributable to demographic changes in the population than to secular increase in the prevalence of osteoporosis.
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- Alwis, Gayani, et al.
(författare)
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Normative Calcaneal Quantitative Ultrasound Data as an Estimation of Skeletal Development in Swedish Children and Adolescents.
- 2010
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Ingår i: Calcified Tissue International. - : Springer Science and Business Media LLC. - 1432-0827 .- 0171-967X. ; 87, s. 493-506
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Tidskriftsartikel (refereegranskat)abstract
- We present age- and gender-specific normative bone status data evaluated by quantitative ultrasound (QUS) in the calcaneus with the Lunar Achilles device and compare these estimates with bone mineral content (BMC) and bone mineral density (BMD) estimated by dual X-ray absorptiometry (DXA). Included were a sample of 518 population-based collected Swedish girls and 558 boys aged 6-19 years. QUS measurements included speed of sound (SOS), broadband ultrasound attenuation (BUA), and stiffness index (SI) in the calcaneus. DXA measurements included BMC and BMD in the femoral neck (FN), lumbar spine (L2-L4), and total body (TB). Height and weight were measured with standard equipment. Age, height, and weight were significantly associated with SOS, BUA, and SI. Compared to SOS, in both girls and boys there was a higher correlation between BUA and FN BMC (r = 0.71 and r = 0.73, respectively), FN BMD (r = 0.68 and r = 0.67, respectively), L2-L4 BMC (r = 0.70 and r = 0.64, respectively), L2-L4 BMD (r = 0.69 and r = 0.64, respectively), TB BMC (r = 0.76 and r = 0.75, respectively), and TB BMD (r = 0.74 and r = 0.74, respectively). The correlations between SOS and FN BMC (r = 0.38 and r = 0.52, respectively), FN BMD (r = 0.41 and r = 0.52, respectively), L2-L4 BMC (r = 0.31 and r = 0.40, respectively), L2-L4 BMD (r = 0.32 and r = 0.41, respectively), TB BMC (r = 0.42 and r = 0.49, respectively), and TB BMD (r = 0.48 and r = 0.54, respectively) were lower, although still significant (all P < 0.001). BUA seems to be the QUS parameter that best resembles the changes in BMC during growth.
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- Alwis, Gayani, et al.
(författare)
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Normative dual energy X-ray absorptiometry data in Swedish children and adolescents.
- 2010
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Ingår i: Acta paediatrica. - : Wiley. - 1651-2227 .- 0803-5253. ; 99, s. 1091-1099
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Tidskriftsartikel (refereegranskat)abstract
- Aim: To present normative dual energy X-ray absorptiometry data in healthy young Swedes. Methods: Included were 710 girls and 759 boys aged 6-30 years from southern Sweden. Bone mineral content, bone mineral density, bone size, lean body and fat mass were measured by dual energy X-ray absorptiometry in total body, lumbar spine, hip, arms and legs. Results: Swedish children had similar bone mass to children in the Netherlands but higher than children in Canada and Korea. Height, weight, bone mass, bone size and lean mass increased at a constant rate from age 6 until the rapid increase in all traits at puberty. The pubertal growth spurt started earlier in girls than in boys, while the spurt in boys was larger in magnitude and occurred for a longer period. Around one-quarter of the adult total body and lumbar spine peak bone mineral content was gained during the 2 years with the fastest gain in both genders. Conclusion: This study presents normative bone mass data in Swedish children, data that are similar to that in Dutch children but higher than in Canadian and Korean children. The gain in Swedish children seems to mimic the gain seen in children in other settings.
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- Aslam, Tehseen, et al.
(författare)
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Integrating system dynamics and multi-objective optimisation for manufacturing supply chain analysis
- 2014
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Ingår i: International Journal of Manufacturing Research. - : InderScience Publishers. - 1750-0605. ; 9:1, s. 27-57
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this paper is to address the dilemma of supply chain management (SCM) within a truly Pareto-based multi-objective context. This is done by introducing an integration of system dynamics and multi-objective optimisation. An extended version of the well-known pedagogical SCMproblem, the Beer Game, originally developed at MIT since the 1960s, has been used as the illustrative example. As will be discussed in the paper, the integrated multi-objective optimisation and system dynamics model has been shown to be very useful for revealing how the parameters in the Beer Game affect the optimality of the three common SCM objectives, namely, the minimisation of inventory cost, backlog cost, and the bullwhip effect.
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- Barendregt, Wolmet, et al.
(författare)
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Lessons from the Evaluation of Game for Developing Number Sense
- 2013
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Ingår i: Chi 2013 Workshop.
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Konferensbidrag (refereegranskat)abstract
- In this paper we describe the methodological lessons that we learned from the evaluation of Fingu, an iPad game to help children between 4 and 7 years old to develop number sense through use of their fingers. We pay attention to the recruitment of the teachers and children, the selection of the measurement instruments, the distribution of the game to the children, handling a group of testers, and controlling of the use of the game during the study.
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