| 1. |
- Carlsson, Lena M S, 1957, et al.
(författare)
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Long-term incidence of serious fall-related injuries after bariatric surgery in Swedish obese subjects.
- 2019
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Ingår i: International journal of obesity (2005). - : Springer Science and Business Media LLC. - 1476-5497 .- 0307-0565. ; 43:4, s. 933-937
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Tidskriftsartikel (refereegranskat)abstract
- Obesity increases risk of falling, but the effect of bariatric surgery on fall-related injuries is unknown. The aim of this study was therefore to study the association between bariatric surgery and long-term incidence of fall-related injuries in the prospective, controlled Swedish Obese Subjects study. At inclusion, body mass index was≥34kg/m2 in men and ≥38kg/m2 in women. The surgery per-protocol group (n=2007) underwent gastric bypass (n=266), banding (n=376), or vertical banded gastroplasty (n=1365), and controls (n=2040) received usual care. At the time of analysis (31 December 2013), median follow-up was 19 years (maximal 26 years). Fall-related injuries requiring hospital treatment were captured using data from the Swedish National Patient Register. During follow-up, there were 617 first-time fall-related injuries in the surgery group and 513 in the control group (adjusted hazard ratio 1.21, 95% CI, 1.07-1.36; P=0.002). The incidence differed between treatment groups (P<0.001, log-rank test) and was higher after gastric bypass than after usual care, banding and vertical banded gastroplasty (adjusted hazard ratio 0.50-0.52, P<0.001 for all three comparisons). In conclusion, gastric bypass surgery was associated with increased risk of serious fall-related injury requiring hospital treatment.
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| 2. |
- Johansson, Birgitta, 1957, et al.
(författare)
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Mindfulness-Based Stress Reduction (MBSR) Delivered Live on the Internet to Individuals Suffering from Mental Fatigue After an Acquired Brain Injury
- 2015
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Ingår i: Mindfulness. - : Springer Science and Business Media LLC. - 1868-8527 .- 1868-8535. ; 6:6, s. 1356-1365
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Tidskriftsartikel (refereegranskat)abstract
- An acquired brain injury often leads to long-lasting mental fatigue, which can have a considerable effect on work and social interactions. Fortunately, the Mindfulness-Based Stress Reduction (MBSR) program has been found to alleviate mental fatigue. The purpose of this feasibility study was to evaluate the success of an interactive MBSR program delivered live online to individuals who have experienced a traumatic brain injury or stroke. We included the following three groups in our study: an Internet group, a face-to-face MBSR group, and an active control group who took weekly walks in natural environments. Thirty-four participants completed the study, and all were suffering from long-lasting mental fatigue after either a traumatic brain injury (16 participants) or a stroke (18 participants). However, seven did not accept to attend an Internet MBSR, and Internet was the only choice for others. We found that, according to the Mental Fatigue Scale (MFS), the program leads to significantly reduced mental fatigue in the Internet group compared with the face-to-face and the control group. Individuals in the MBSR groups also exhibited an improved ability to process two temporally close targets (attentional blink task), while this was not detected in the control group. In conclusion, we believe that it is possible for individuals suffering from mental fatigue after an acquired brain injury to obtain positive results through enrollment in a live, interactive, online MBSR program. This is promising, as the Internet is accessible to many individuals, irrespective of where they live. Further randomized control studies comparing are warranted.
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| 3. |
- Aevarsson, Arnthór, et al.
(författare)
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Going to extremes - a metagenomic journey into the dark matter of life
- 2021
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Ingår i: FEMS Microbiology Letters. - : Oxford University Press (OUP). - 1574-6968. ; 368:12
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Forskningsöversikt (refereegranskat)abstract
- The Virus-X-Viral Metagenomics for Innovation Value-project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.
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| 4. |
- Ahlgren, Serina, et al.
(författare)
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Description of the Agrosfär model – a tool for climate impact assessment of crop and animal production systems in Sweden : Version 1: Crops, milk and beef
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The agricultural sector in Sweden needs to cut GHG emissions and contribute to the climate goal of net-zero emissions by 2045. The GHG reduction goal for agricultural emissions is not quantified, but the Swedish climate policy framework states that ‘the Swedish food production shall increase as much as possible with as little climate impact as possible’ and multiple key actors within the sector of food and agriculture have developed roadmaps or industry specific goals for reducing GHG emissions from the sector. Consequently, requirements of transparent GHG accounting and reporting are increasing within the agricultural sector, both at national and international level. The purpose of the Agrosfär tool is to establish an automatic data driven climate calculator used to calculate GHG emissions from agricultural products and on farm enterprise level. The automation and automatic data collection will save time, increase accuracy of the calculations, and simplify updates of the tool to keep it aligned with the most recent climate data and climate reporting methodology. It will make it possible to continuously carry out follow-ups on climate performance indicators and measure improvements from climate measures taken. A working group consisting of Swedish agricultural life cycle assessment experts have developed the framework of the tool, e.g. setting system boundaries, selecting methodologies and input data. A technical team has developed algorithms, a digital interface and coupled the tool to other existing agricultural databases providing farm specific information on crop and animal production data, soil characteristics, carbon footprints and amounts of purchased inputs etc. The tool and user interface have been developed based on input from farmers through prototyping and in-depth interviews. For general guidelines on methodology the calculation model follows the Product Environmental Footprint Category Rules (PEFCR), the International Dairy Federation (IDF)’s approach for carbon footprint for the dairy sector and FAO Livestock Environmental Assessment and Performance guidelines (FAO LEAP). Where standards have diverged or where assumptions have been required the working group has made expert judgements on which method/guideline to follow or what assumptions to make. A first version of the tool, a so called minimal viable product (MVP) has been developed which will be the basis for further development. The MVP contains an animal and crop module and can calculate the carbon footprint of crops, milk and beef. Future development possibilities of the tool and calculation model is described in chapter 7, such as enabling climate calculations on enterprise level, develop modules for more animal production types, deepen the integration between the crop and animal modules, expand sources for automatic data collection, develop a carbon sequestration module and other technical and methodological improvements to ensure alignment with important climate reporting standards. The report will be repeatedly updated as the tool develops, and new versions of the tool are released.
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| 5. |
- Ahlgren, Serina, et al.
(författare)
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Description of the Agrosfär model – a tool for the climate impact assessment of farms, crop and animal production systems in Sweden
- 2024
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The agricultural sector in Sweden needs to cut GHG emissions and contribute to the climate goal of net-zero emissions by 2045. The GHG reduction goal for agricultural emissions is not quantified, but the Swedish climate policy framework states that ‘Swedish food production shall increase as much as possible with as little climate impact as possible’. Multiple key actors within the sector of food and agriculture have developed roadmaps or industry specific goals for reducing GHG emissions from the sector. Consequently, requirements for transparent GHG accounting and reporting are increasing within the agricultural sector, both on a national and international level. The purpose of the Agrosfär tool is to establish an automatic data driven climate calculator used to calculate GHG emissions from agricultural products and on a farm enterprise level. Automation and automatic data collection will save time, increase the accuracy of the calculations, and simplify updates of the tool to keep it aligned with the most recent climate data and climate reporting methodology. It will make it possible to continuously carry out follow-ups on climate performance indicators and measure improvements from climate measures taken. A working group consisting of agricultural life cycle assessment experts has developed the framework of the tool (e.g., setting system boundaries, selecting methodologies and input data). A technical team has developed algorithms, a digital interface and coupled the tool to other existing agricultural databases, providing farm specific information on crop and animal production data, soil characteristics, carbon footprints and amounts of purchased inputs etc. The tool and user interface have been developed based on input from farmers through prototyping and in-depth interviews. The priority guidelines on which the calculation model is based are the Product Environmental Footprint Category Rules (PEFCR), the International Dairy Federation (IDF)’s approach for carbon footprint for the dairy sector, and FAO Livestock Environmental Assessment and Performance guidelines (FAO LEAP). From the farm perspective, the Greenhouse Gas Protocol (GHG Protocol) Corporate Standard, GHG Protocol Agricultural Guidance (Scope 1 & 2) and GHG Protocol Corporate value chain (Scope 3) Accounting and Reporting Standard are guiding standards. Where standards have diverged or where assumptions have been required, the working group has made expert judgements on which method/guideline to follow or what assumptions to make. A first version of the tool, first described in report version 1, was developed as the basis for further development. The first version contains an animal and a crop module, and can calculate the carbon footprint of crops, milk and beef. This report (version 1.1) has been updated to include the most recent developments of the tool. The main change is that the tool can now also be used to calculate farm climate impact on a yearly basis. Future possibilities to develop the tool and calculation model are described in chapter 7, including suggestions for developing modules for more animal production types, deepening the integration between the crop and animal modules, expanding sources for automatic data collection, developing a carbon sequestration module, and other technical and methodological improvements to ensure alignment with important climate reporting standards. The report will be repeatedly updated as the tool develops, and new versions of the tool are released.
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| 6. |
- Barmpatsalou, Vicky, et al.
(författare)
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Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs
- 2023
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Ingår i: European Journal of Pharmaceutical Sciences. - : Elsevier. - 0928-0987 .- 1879-0720. ; 181
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Tidskriftsartikel (refereegranskat)abstract
- Colonic mucus plays a key role in colonic drug absorption. Mucus permeation assays could therefore provide useful insights and support rational formulation development in the early stages of drug development. However, the collection of native colonic mucus from animal sources is labor-intensive, does not yield amounts that allow for routine experimentation, and raises ethical concerns. In the present study, we developed an in vitro porcine artificial colonic mucus model based on the characterization of native colonic mucus. The structural properties of the artificial colonic mucus were validated against the native secretion for their ability to capture key diffusion patterns of macromolecules in native mucus. Moreover, the artificial colonic mucus could be stored under common laboratory conditions, without compromising its barrier properties. In conclusion, the porcine artificial colonic mucus model can be considered a biorelevant way to study the diffusion behavior of drug candidates in colonic mucus. It is a cost-efficient screening tool easily incorporated into the early stages of drug development and it contributes to the implementation of the 3Rs (refinement, reduction, and replacement of animals) in the drug development process.
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| 7. |
- Barmpatsalou, Vicky, et al.
(författare)
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Physiological properties, composition and structural profiling of porcine gastrointestinal mucus
- 2021
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Ingår i: European journal of pharmaceutics and biopharmaceutics. - : Elsevier. - 0939-6411 .- 1873-3441. ; 169, s. 156-167
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Tidskriftsartikel (refereegranskat)abstract
- The gastrointestinal mucus is a hydrogel that lines the luminal side of the gastrointestinal epithelium, offering barrier protection from pathogens and lubrication of the intraluminal contents. These barrier properties likewise affect nutrients and drugs that need to penetrate the mucus to reach the epithelium prior to absorption. In order to assess the potential impact of the mucus on drug absorption, we need information about the nature of the gastrointestinal mucus. Today, most of the relevant available literature is mainly derived from rodent studies. In this work, we used a larger animal species, the pig model, to characterize the mucus throughout the length of the gastrointestinal tract. This is the first report of the physiological properties (physical appearance, pH and water content), composition (protein, lipid and metabolite content) and structural profiling (rheology and gel network) of the porcine gastrointestinal mucus. These findings allow for direct comparisons between the characteristics of mucus from various segments and can be further utilized to improve our understanding of the role of the mucus on region dependent drug absorption. Additionally, the present work is expected to contribute to the assessment of the porcine model as a preclinical species in the drug development process.
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| 8. |
- Bentmar Holgersson, Magdalena, et al.
(författare)
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Lower prostate cancer risk in Swedish men with the androgen receptor E213 A-allele
- 2017
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Ingår i: Cancer Causes & Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 28:3, s. 227-233
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Tidskriftsartikel (refereegranskat)abstract
- In a previous population-based study on 3369 European men with self-reported prostate cancer (PCa), it was shown that androgen receptor (AR) haplotype designated H2 was associated with high levels of serum PSA (prostate-specific antigen) concentration, and, at the same time, with low risk for PCa. The aim of this study was to replicate this finding in other cohorts, with registry-based cancer diagnosis. Using data from two population-based cohorts; the Malmo Diet and Cancer Study (MDCS, n = 12,121) and the Swedish Osteoporotic fractures in men study (MrOS, n = 1,120), 628 men with PCa and 1,374 controls were identified and genotyped. PCa data were collected from the Swedish national cancer registry. PCa odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for carriers of the particular AR haplotype, tagged by the rs6624304 T-allele. The 15% of men who were carriers of the AR haplotype H2 had approximately one-third lower risk for PCa diagnosis compared to those with the most common H1 variant (OR 0.65; 95% CI 0.45-0.94; p = 0.021). The same trend, although not statistically significant (OR 0.75; 95% CI 0.47-1.24; p = 0.275), was observed in MrOS Sweden. When both cohorts were merged, an even more significant result was observed (OR 0.68; 95% CI 0.51-0.90; p = 0.008). Swedish men with the variant AR haplotype H2, tagged by rs6624304, have significantly lower risk of PCa compared to those with the more common variant.
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| 9. |
- Carlsson, Lena M S, 1957, et al.
(författare)
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Life expectancy after bariatric surgery or usual care in patients with or without baseline type 2 diabetes in Swedish Obese Subjects.
- 2023
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Ingår i: International journal of obesity (2005). - 1476-5497. ; 47, s. 931-8
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Tidskriftsartikel (refereegranskat)abstract
- To determine life expectancy and causes of death after bariatric surgery in relation to baseline type 2 diabetes (T2D) in the prospective, Swedish Obese Subjects study.The study included 2010 patients with obesity who underwent bariatric surgery and 2037 matched controls, eligible for surgery. The surgery group underwent gastric bypass (n=265), banding (n=376), or vertical banded gastroplasty (n=1369). The control group (n=2037) received usual obesity care. Causes of death were obtained from the Swedish Cause of Death Register, case sheets and autopsy reports, in patients with baseline T2D (n=392 surgery patients/n=305 controls) or non-T2D (n=1609 surgery patients/n=1726 controls) during a median follow-up 26 years.In T2D and non-T2D subgroups, bariatric surgery was associated with increased life expectancy (2.1, 95% confidence interval (95% CI) 0.2-4.0; and 1.6, 0.5-2.7 years, respectively) and reduced overall mortality (adjusted hazard ratio (adjHR)=0.77, 95% CI: 0.61-0.97; and 0.82, 0.72-0.94, respectively), and the treatment benefit was similar (interaction p=0.615). Bariatric surgery was associated with reduced cardiovascular mortality in both subgroups (adjHR=0.65, 95% CI: 0.46-0.91; and 0.70, 0.55-0.88, respectively (interaction p=0.516)).Bariatric surgery is associated with similar reduction of overall and cardiovascular mortality and increased life expectancy regardless of baseline diabetes status.
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| 10. |
- Carlsson, Lena M S, 1957, et al.
(författare)
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Long-term incidence of microvascular disease after bariatric surgery or usual care in patients with obesity, stratified by baseline glycaemic status: a post-hoc analysis of participants from the Swedish Obese Subjects study.
- 2017
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Ingår i: The lancet. Diabetes & endocrinology. - 2213-8595. ; 5:4, s. 271-279
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Tidskriftsartikel (refereegranskat)abstract
- Bariatric surgery is associated with remission of diabetes and prevention of diabetic complications in patients with obesity and type 2 diabetes. Long-term effects of bariatric surgery on microvascular complications in patients with prediabetes are unknown. The aim of this study was to examine the effects of bariatric surgery on incidence of microvascular complications in patients with obesity stratified by baseline glycaemic status.Patients were recruited to the Swedish Obese Subjects (SOS) study between Sept 1, 1987, and Jan 31, 2001. Inclusion criteria were age 37-60 years and BMI of 34 kg/m(2) or greater in men and 38 kg/m(2) or greater in women. Exclusion criteria were identical in surgery and control groups and designed to exclude patients not suitable for surgery. The surgery group (n=2010) underwent gastric bypass (265 [13%]), gastric banding (376 [19%]), or vertical-banded gastroplasty (1369 [68%]). Participants in the control group (n=2037) received usual care. Bodyweight was measured and questionnaires were completed at baseline and at 0·5 years, 1 year, 2 years, 3 years, 4 years, 6 years, 8 years, 10 years, 15 years, and 20 years. Biochemical variables were measured at baseline and at 2 years, 10 years, and 15 years. We categorised participants into subgroups on the basis of baseline glycaemic status (normal [fasting blood glucose concentration <5·0 mmol/L], prediabetes [5·0-6·0 mmol/L], screen-detected diabetes [≥6·1 mmol/L at baseline visit without previous diagnosis], and established diabetes [diagnosis of diabetes before study inclusion]). We obtained data about first incidence of microvascular disease from nationwide registers and about diabetes incidence at study visits at 2 years, 10 years, and 15 years. We did the main analysis by intention to treat, and subgroup analyses after stratification by baseline glycaemic status and by diabetes status at the 15 year follow-up. The SOS study is registered with ClinicalTrials.gov, NCT01479452.4032 of the 4047 participants in the SOS study were included in this analysis. We excluded four patients with suspected type 1 diabetes, and 11 patients with unknown glycaemic status at baseline. At baseline, 2838 patients had normal blood glucose, 591 had prediabetes, 246 had screen-detected diabetes, and 357 had established diabetes. Median follow-up was 19 years (IQR 16-21). We identified 374 incident cases of microvascular disease in the control group and 224 in the surgery group (hazard ratio [HR] 0·56, 95% CI 0·48-0·66; p<0·0001). Interaction between baseline glycaemic status and effect of treatment on incidence of microvascular disease was significant (p=0·0003). Unadjusted HRs were lowest in the subgroup with prediabetes (0·18, 95% CI 0·11-0·30), followed by subgroups with screen-detected diabetes (0·39, 0·24-0·65), established diabetes (0·54, 0·40-0·72), and normoglycaemia (0·63, 0·48-0·81). Surgery was associated with reduced incidence of microvascular events in people with prediabetes regardless of whether they developed diabetes during follow-up.Bariatric surgery was associated with reduced risk of microvascular complications in all subgroups, but the greatest relative risk reduction was observed in patients with prediabetes at baseline. Our results suggest that prediabetes should be treated aggressively to prevent future microvascular events, and effective non-surgical treatments need to be developed for this purpose.US National Institutes of Health, Swedish Research Council, Sahlgrenska University Hospital Regional Agreement on Medical Education and Research, and Swedish Diabetes Foundation.
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