| 1. |
- Sun, Aijun, 1973-
(författare)
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Radiolabeled acetate PET in oncology imaging : studies on head and neck cancer, prostate cancer and normal distribution
- 2010
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The use of positron emission tomography (PET) for imaging in oncology has grown rapidly in recent years. 2-[18F]-fluorodeoxyglucose (FDG) is the most common tracer of PET, although drawbacks exist. Radiolabeled 1-[11C]-acetate (C-AC) is a simple probe for evaluation of perfusion, anabolism (lipogenesis) and catabolism (oxidative metabolism) in all living tissues. This study explored the potential of AC PET in head and neck cancer, benign and malignant lymph nodes in prostate cancer and normal distribution. In head and neck cancer, C-AC PET detected more primaries and lymph node metastases than FDG PET. The mean primary tumor volumes delineated by C-AC was 51% larger than that of FDG before radiotherapy (RT). Both FDG and C-AC PET tumor volumes must be carefully validated before used in clinical routine. Baseline tumor clearance rate (kmono) was higher in complete responders (CR) than that in partial responders (PR). kmono tended to correlate inversely with FDG SUV at baseline. Radiosensitive tumors might rely predominantly on oxidative metabolism for their biogenetic needs. kmono increased in PR during RT. The potential reversibility of impaired kmono in radioresistant tumors imply that treatment targeting the intermediary metabolism might improve the outcome. Tumor relative perfusion index (rF) and kmono were coupled in CR throughout the RT, but not in PR. Dynamic C-AC PET provides a new non-invasive method to simultaneously evaluate the tumor oxidative metabolism and perfusion which link the RT response in patients by a single tracer injection. In prostate cancer, elevated C-AC accumulation is common in benign inguinal lymph nodes, probably due to increased lipogenesis rather than lymphatic drainage. CT Hounsfield unit of benign nodes was lower than that of metastases, suggesting that density measurement using CT might improve the specificity of nodal staging of prostate cancer. A novel tracer 2-[18F]-fluoroacetate (F-AC) was synthesized and used for dynamic PET-CT imaging in animals. Compared with C-AC PET-CT, F-AC showed prolonged blood retention, no detectable trapping in myocardium and salivary glands, rapid excretion from liver to bile and urine and de-fluorination resulting in intensive skeletal activity. F-AC does not mimic the normal physiologic path of C-AC and appears to be of little use for assessment of perfusion, intermediary metabolism or lipogenesis.
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| 2. |
- Cai, Yixiao, 1986-
(författare)
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Bio-Nano Interactions : Synthesis, Functionalization and Characterization of Biomaterial Interfaces
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Current strategies for designing biomaterials involve creating materials and interfaces that interact with biomolecules, cells and tissues. This thesis aims to investigate several bioactive surfaces, such as nanocrystalline diamond (NCD), hydroxyapatite (HA) and single crystalline titanium dioxide, in terms of material synthesis, surface functionalization and characterization.Although cochlear implants (CIs) have been proven to be clinically successful, the efficiency of these implants still needs to be improved. A CI typically only has 12-20 electrodes while the ear has approximately 3400 inner hair cells. A type of micro-textured NCD surface that consists of micrometre-sized nail-head-shaped pillars was fabricated. Auditory neurons showed a strong affinity for the surface of the NCD pillars, and the technique could be used for neural guidance and to increase the number of stimulation points, leading to CIs with improved performance.Typical transparent ceramics are fabricated using pressure-assisted sintering techniques. However, the development of a simple energy-efficient production method remains a challenge. A simple approach to fabricating translucent nano-ceramics was developed by controlling the morphology of the starting ceramic particles. Translucent nano-ceramics, including HA and strontium substituted HA, could be produced via a simple filtration process followed by pressure-less sintering. Furthermore, the application of such materials as a window material was investigated. The results show that MC3T3 cells could be observed through the translucent HA ceramic for up to 7 days. The living fluorescent staining confirmed that the MC3T3 cells were visible throughout the culture period.Single crystalline rutile possesses in vitro bioactivity, and the crystalline direction affects HA formation. The HA growth on (001), (100) and (110) faces was investigated in a simulated body fluid in the presence of fibronectin (FN) via two different processes. The HA layers on each face were analysed using different characterization techniques, revealing that the interfacial energies could be altered by the pre-adsorbed FN, which influenced HA formation.In summary, micro textured NCD, and translucent HA and FN functionalized single crystalline rutile, and their interactions with cells and biomimetic HA were studied. The results showed that controlled surface properties are important for enhancing a material’s biological performance.
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| 3. |
- Liu, Yu, 1991-
(författare)
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Enable the landing of Internet of Things: a holistic approach
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Internet of Things (IoT) envisions a world where physical assets are fully connected with the Internet infrastructure to provide digital services. With the advancement of information and communication technologies, IoT applications have experienced a growth in many industries and are anticipated to reshape the landscape of social life and industry production. The emergence of cloud computing has accelerated the widespread employment of IoT technologies, benefiting from superb computation, storage, analytics and visualization capabilities. However, the landing of IoT still encounters several open challenges, i.e., interoperability and compatibility between link layer protocols, subsystems, and back-end services. Moreover, a uniform scheme for device management and the heterogeneity of data have not been tackled by cloud suppliers. In this dissertation, a data-centric IoT framework based on public cloud is presented to address these challenges. It features WiFi, Thread, and LoRaWAN networks to provide support for personal, local and wide area networks so as to enable wide coverage of IoT applications. A security analysis taxonomy is proposed to perform security assessment of IoT field networks and enhance security considerations. In light of the recent industrial tendency that cloud computing is evolving towards edge-cloud computing, further reinforcement of the IoT framework is proposed with the novel edge-cloud computing paradigm. A comprehensive performance evaluation of the edge-cloud computing stack is conducted, while the communication, computing and intelligence capabilities are thoroughly studied for future cloud and edge computing enabled IoT applications. Furthermore, the cloud and edge computing enabled IoT landing with a digitalization practice is showcased in the vertical plant wall industry. A remote monitoring and management system for indoor climate control has been developed based on the IoT framework. As a further step, it is also demonstrated how machine learning can be leveraged to achieve artificial intelligence in IoT with a case study, i.e., anomaly detection for indoor climate. Based on the expertise we accumulated from the industry digitalization practice, a reference framework that intends to guide small and medium sized enterprises to perform IoT enabled digital transformation is proposed. In this way, a true landing of the IoT technology in the society has been demonstrated.
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| 4. |
- Dandan, Kinan, 1976-
(författare)
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Enabling Surface Cleaning Robot for Large Food Silo
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Working conditions in the dry cleaning and sanitation of confined interior spaces are often extreme, and workers need overall protection with tight clothing, helmets, face mask, earmuffs, and respirators. The environment is dirty, noisy with bad visibility and heavy with a high static work load. Dry cleaning is mainly practised in silos for grain, foodstuff and flour, etc. The inside of the silo is a hazardous environment due to many factors such as an unsafe oxygen level, engulfment, biological, mechanical, electrical, and atmospheric hazards. The requirements of the EU norms related to hygiene and food quality indicate that silos should be cleaned frequently and cleaning is obligatory after a silo is totally emptied. Therefore, there is an increased societal need for silo cleaning and a natural necessity to replace humans by robot manipulators in executing this risky and dangerous job.This thesis presents a new concept of a flexible crawling mechanism for an industrial food cleaning robot, which is evaluated from the viewpoint of the capability to work inside a large food silo, scanning the desired surface, and performing the cleaning task. The main research questions investigated in this thesis are about: how to select the most important characteristics in designing a robot to fulfil the surface cleaning operation of a large confined space; how the crawling movement affects the dynamic behaviour of the robot mechanism; how the cleaning process affects the dynamic behaviour of the robot mechanism; how to develop the control of the robot to realize the locomotion and the cleaning process.The structure of the robot and the cleaning technology are well defined after an overview of the existing technologies and solutions for cleaning large confined spaces. The robot design is based on a suspension and crawling system, using minimal actuators, where the force of gravity is well used to simplify the control system and to stabilise the robot. Further, the static and dynamic analysis of the mechanical system is studied. In addition, the control architecture of the system is performed, where the required sensors and control algorithm are given. A scale model testing has also been used to verify the locomotion of the concept, while simple controllers and algorithms are used to manage the motions of the prototype.
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| 5. |
- Garpebring, Anders, 1980-
(författare)
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Contributions to quantitative dynamic contrast-enhanced MRI
- 2011
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Dynamic contrast-enhanced MRI (DCE-MRI) has the potential to produce images of physiological quantities such as blood flow, blood vessel volume fraction, and blood vessel permeability. Such information is highly valuable, e.g., in oncology. The focus of this work was to improve the quantitative aspects of DCE-MRI in terms of better understanding of error sources and their effect on estimated physiological quantities. Methods: Firstly, a novel parameter estimation algorithm was developed to overcome a problem with sensitivity to the initial guess in parameter estimation with a specific pharmacokinetic model. Secondly, the accuracy of the arterial input function (AIF), i.e., the estimated arterial blood contrast agent concentration, was evaluated in a phantom environment for a standard magnitude-based AIF method commonly used in vivo. The accuracy was also evaluated in vivo for a phase-based method that has previously shown very promising results in phantoms and in animal studies. Finally, a method was developed for estimation of uncertainties in the estimated physiological quantities. Results: The new parameter estimation algorithm enabled significantly faster parameter estimation, thus making it more feasible to obtain blood flow and permeability maps from a DCE-MRI study. The evaluation of the AIF measurements revealed that inflow effects and non-ideal radiofrequency spoiling seriously degrade magnitude-based AIFs and that proper slice placement and improved signal models can reduce this effect. It was also shown that phase-based AIFs can be a feasible alternative provided that the observed difficulties in quantifying low concentrations can be resolved. The uncertainty estimation method was able to accurately quantify how a variety of different errors propagate to uncertainty in the estimated physiological quantities. Conclusion: This work contributes to a better understanding of parameter estimation and AIF quantification in DCE-MRI. The proposed uncertainty estimation method can be used to efficiently calculate uncertainties in the parametric maps obtained in DCE-MRI.
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| 6. |
- Häggström, Ida, 1982-
(författare)
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Quantitative methods for tumor imaging with dynamic PET
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- There is always a need and drive to improve modern cancer care. Dynamic positron emission tomography (PET) offers the advantage of in vivo functional imaging, combined with the ability to follow the physiological processes over time. In addition, by applying tracer kinetic modeling to the dynamic PET data, thus estimating pharmacokinetic parameters associated to e.g. glucose metabolism, cell proliferation etc., more information about the tissue's underlying biology and physiology can be determined. This supplementary information can potentially be a considerable aid when it comes to the segmentation, diagnosis, staging, treatment planning, early treatment response monitoring and follow-up of cancerous tumors.We have found it feasible to use kinetic parameters for semi-automatic tumor segmentation, and found parametric images to have higher contrast compared to static PET uptake images. There are however many possible sources of errors and uncertainties in kinetic parameters obtained through compartment modeling of dynamic PET data. The variation in the number of detected photons caused by the random nature of radioactive decay, is of course always a major source. Other sources may include: the choice of an appropriate model that is suitable for the radiotracer in question, camera detectors and electronics, image acquisition protocol, image reconstruction algorithm with corrections (attenuation, random and scattered coincidences, detector uniformity, decay) and so on. We have found the early frame sampling scheme in dynamic PET to affect the bias and uncertainty in calculated kinetic parameters, and that scatter corrections are necessary for most but not all parameter estimates. Furthermore, analytical image reconstruction algorithms seem more suited for compartment modeling applications compared to iterative algorithms.This thesis and included papers show potential applications and tools for quantitative pharmacokinetic parameters in oncology, and help understand errors and uncertainties associated with them. The aim is to contribute to the long-term goal of enabling the use of dynamic PET and pharmacokinetic parameters for improvements of today's cancer care.
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| 7. |
- Johansson, Adam, 1984-
(författare)
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Magnetic resonance imaging with ultrashort echo time as a substitute for X-ray computed tomography
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Radiotherapy dose calculations have evolved from simple factor based methods performed with pen and paper, into computationally intensive simulations based on Monte Carlo theory and energy deposition kernel convolution.Similarly, in the field of positron emission tomography (PET), attenuation correction, which was originally omitted entirely, is now a crucial component of any PET reconstruction algorithm.Today, both of these applications – radiotherapy and PET – derive their needed in-tissue radiation attenuation coefficients from images acquired with X-ray computed tomography (CT). Since X-ray images are themselves acquired using ionizing radiation, the intensity at a point in an image will reflect the radiation interaction properties of the tissue located at that point.Magnetic resonance imaging (MRI), on the other hand, does not use ionizing radiation. Instead MRI make use of the net transverse magnetization resulting from the spin polarization of hydrogen nuclei. MR image contrast can be varied to a greater extent than CT and the soft tissue contrast is, for most MR sequences, superior to that of CT. Therefore, for many cases, MR images provide a considerable advantage over CT when identifying or delineating tumors or other diseased tissues.For this reason, there is an interest to replace CT with MRI for a great number of diagnostic and therapeutic workflows. Also, replacing CT with MRI would reduce the exposure to ionizing radiation experienced by patients and, by extension, reduce the associated risk to induce cancer.In part MRI has already replaced CT, but for radiotherapy dose calculations and PET attenuation correction, CT examinations are still necessary in clinical practice. One of the reasons is that the net transverse magnetization imaged in MRI cannot be converted into attenuation coefficients for ionizing radiation in a straightforward way. More specifically, regions with similar appearance in magnetic resonance (MR) images, such as bone and air pockets, are found at different ends of the spectrum of attenuation coefficients present in the human body. In a CT image, bone will appear bright white and air as black corresponding to high and no attenuation, respectively. In an MR image, bone and air both appear dark due to the lack of net transverse magnetization.The weak net transverse magnetization of bone is a result of low hydrogen density and rapid transverse relaxation. A particular category of MRI sequences with so-called ultrashort echo time (UTE) can sample the MRI signal from bone before it is lost due to transverse relaxation. Thus, UTE sequences permit bone to be imaged with MRI albeit with weak intensity and poor resolution.Imaging with UTE in combination with careful image analysis can permit ionizing-radiation attenuation-maps to be derived from MR images. This dissertation and appended articles present a procedure for this very purpose. However, as attenuation coefficients are radiation-quality dependent the output of the method is a Hounsfield unit map, i.e. a substitute for a CT image. It can be converted into an attenuation map using conventional clinical procedure.Obviating the use of CT would reduce the number of examinations that patients have to endure during preparation for radiotherapy. It would also permit PET attenuation correction to be performed on images from the new imaging modality that combines PET and MRI in one scanner – PET/MR.
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| 8. |
- Jonsson, Joakim, 1984-
(författare)
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Integration of MRI into the radiotherapy workflow
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The modern day radiotherapy treatments are almost exclusively based on computed tomography (CT) images. The CT images are acquired using x-rays, and therefore reflect the radiation interaction properties of the material. This information is used to perform accurate dose calculation by the treatment planning system, and the data is also well suited for creating digitally reconstructed radiographs for comparing patient set up at the treatment machine where x-ray images are routinely acquired for this purpose.The magnetic resonance (MR) scanner has many attractive features for radiotherapy purposes. The soft tissue contrast as compared to CT is far superior, and it is possible to vary the sequences in order to visualize different anatomical and physiological properties of an organ. Both of these properties may contribute to an increase in accuracy of radiotherapy treatment.Using the MR images by themselves for treatment planning is, however, problematic. MR data reflects the magnetic properties of protons, and thus have no connection to the radiointeraction properties of the material. MRI also has inherent difficulty in imaging bone, which will appear in images as areas of no signal similar to air. This makes both dose calculation and patient positioning at the treatment machine troublesome.There are several clinics that use MR images together with CT images to perform treatment planning. The images are registered to a common coordinate system, a process often described as image fusion. In these cases, the MR images are primarily used for target definition and the CT images are used for dose calculations. This method is now not ideal, however, since the image fusion may introduce systematic uncertainties into the treatment due to the fact that the tumor is often able to move relatively freely with respect to the patients’ bony anatomy and outer contour, especially when the image registration algorithms take the entire patient anatomy in the volume of interest into account.The work presented in the thesis “Integration of MRI into the radiotherapy workflow” aim towards investigating the possibilities of workflows based entirely on MRI without using image registration, as well as workflows using image registration methods that are better suited for targets that can move with respect to surrounding bony anatomy, such as the prostate.
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| 9. |
- Karlsson, Mattias E.
(författare)
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Fundamentals of Polyethylene Composites for HVDC Cable Insulation – Interfaces and Charge Carriers
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Power transmission over long distances by using high voltage direct current (HVDC) cables is important for the transition from fossil energy to using renewable energy sources, e.g. wind, solar and water. Higher operating voltages enable longer transmission lines but better insulation materials with a much lower conductivity than today´s crosslinked polyethylene (PE) are required to reach the goal of 1 MV by 2030. Nanocomposites consisting of small fractions of metal oxide nanoparticles in PE are promising insulation materials, showing ca. 100 times lower conductivity. The reasons for the better insulating properties are however not fully understood.The properties of PE and inorganic nanoparticles were studied in this project to evaluate the influence of different material parameters on the conductivity of the cable insulation material. For pristine PE, the polymer morphology and oxidation were found to have a significant impact on the conductivity. For PE nanocomposites, the particle/polymer interface was shown to adsorb polar molecules, which are present in PE cable insulation. A suggested hypothesis is that the adsorption on particle surfaces results in cleaning of the bulk polymer from impurities, which in turn contributes to decreased nanocomposite conductivity. Since the particle interface is believed to be decisive for the nanocomposite properties, the role of particle terminations was investigated in detail. Oxygen dominated particle terminations resulted in 2 times higher composite conductivity than with zinc dominated surfaces, while fully oxygen covered surfaces showed 10 times higher conductivity. Composite systems with micro-sized particles allowed for evaluating parameters independently, which is not possible for nanocomposites. Terminations of ‘PE-like’ hydrocarbon chains lowered the conductivity and these trends could also be transferred to similar zinc oxide nanocomposite systems.
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| 10. |
- Karlsson, Mikael, 1972-
(författare)
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Filantropi under konstruktion : En undersökning av Sällskapet DBW:s samhällsengagemang 1814–1876
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The 19th century was a time when a large number of voluntary associations were being formed both in Sweden and in Europe as a whole. Their ambition was to engage in health care and poor relief issues as well as in the educational system. Furthermore, the general idea was to promote temperance and foster a sense of thrift among the poor and the working class population.While the starting-point of the thesis was the question as to why the voluntary associations founded various charitable activities as well as how the philanthropy was designed, organised and modified throughout the century, the aim has been to elucidate the motive force and incentives for their social reforms. In order to answer the two main questions of the dissertation, the association De Badande Wännerna (the DBW), which engaged in several philanthropic activities in the Swedish province of Gotland as early as the 1810s, has been selected for a case study.In the literature a number of different reasons have been stressed as to why voluntary associations chose to engage in charitable activities. In order to shed light on what factors that underlay their philanthropic work, the process of negotiation regarding the various institutions established by the DBW, as well as the practical layout of the establishments, have been analysed from the perspectives of a theoretical model based on affinity groups.The study has shown that the incentives of philanthropy were complex. Furthermore, the incentives changed concurrently with the expansion of the public poor relief and educational system, which from the middle of the 19th century took over many of the humanitarian efforts hitherto run by the voluntary associations. The result of this development was that the voluntary associations created new spheres of activity. They continued to fulfil important societal functions, but their establishments also fulfilled a more internal desire for pleasure and delights.
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