| 1. |
- Karlsson, Magnus, et al.
(författare)
-
Patients With Hip Osteoarthritis Have a Phenotype With High Bone Mass and Low Lean Body Mass.
- 2014
-
Ingår i: Clinical Orthopaedics and Related Research. - : Ovid Technologies (Wolters Kluwer Health). - 0009-921X. ; 472:4, s. 1224-1229
-
Tidskriftsartikel (refereegranskat)abstract
- Although hip osteoarthritis (OA) is common, its etiology is poorly understood. Specifically, it is not known whether hip OA is associated with abnormal relationships among the anthropometric and musculoskeletal characteristics that are associated with OA in general.
|
|
| 2. |
- Derks, Jan, 1977, et al.
(författare)
-
Reconstructive surgical therapy of peri-implantitis: A multicenter randomized controlled clinical trial
- 2022
-
Ingår i: Clinical Oral Implants Research. - : Wiley. - 0905-7161 .- 1600-0501. ; 33:9, s. 921-944
-
Tidskriftsartikel (refereegranskat)abstract
- Objective To evaluate the potential benefit of the use of a bone substitute material in the reconstructive surgical therapy of peri-implantitis. Methods In this multicenter randomized clinical trial, 138 patients (147 implants) with peri-implantitis were treated surgically, randomized by coin toss to either a control (access flap surgery) or a test group (reconstructive surgery using bone substitute material). Clinical assessments, including probing pocket depth (PPD), bleeding and suppuration on probing (BOP & SOP) as well as soft tissue recession (REC), were recorded at baseline, 6 and 12 months. Marginal bone levels (MBL), measured on intra-oral radiographs, and patient-reported outcomes (PROs) were recorded at baseline and 12 months. No blinding to group allocation was performed. The primary outcome at 12 months was a composite measure including (i) implant not lost, (ii) absence of BOP/SOP at all aspects, (iii) PPD <= 5 mm at all aspects and (iv) <= 1 mm recession of mucosal margin on the buccal aspect of the implant. Secondary outcomes included (i) changes of MBL, (ii) changes of PPD, BOP%, and buccal KM, (iii) buccal REC and (iv) patient-reported outcomes. Results During follow-up, four implants (one in the test group, three in the control group) in four patients were removed due to disease progression. At 12 months, a total of 69 implants in the test and 68 implants in the control group were examined. Thus, 16.4% and 13.5% of implants in the test and control group, respectively, met all predefined criteria of the composite outcome. PPD reduction and MBL gain were 3.7 mm and about 1.0 mm in both groups. Reduction in mean BOP% varied between 45% (test) and 50% (control), without significant differences between groups. Buccal REC was less pronounced in the test group (M = 0.7, SD = 0.9 mm) when compared to controls (M = 1.1, SD = 1.5 mm). PROs were favorable in both groups without significant differences. One case of allergic reaction to the antibiotic therapy was recorded. No other adverse events were noted. Conclusions Surgical therapy of peri-implantitis effectively improved the clinical and radiographic status at 12 months. While the use of a bone substitute material did not improve reductions of PPD and BOP, buccal REC was less pronounced in the test group. Patient satisfaction was high in both groups.
|
|
| 3. |
- Frogner, Kenneth, et al.
(författare)
-
Towards manufacturing of perfect magnets
- 2010
-
Ingår i: Proceeding of the conference on Flexible Automation and Intelligent Manufacturing, FAIM2010.
-
Konferensbidrag (refereegranskat)abstract
- Abstract in UndeterminedThe paper describes a magnetizing machine for producing permanent magnets of desired magnetization pattern by use of feedback control. This will in theory mean that an ideal magnetization pattern can be realized, what could be described as a perfect magnet. The machine is to be used for applications requiring high accuracy magnets in terms of the shape of the magnetized area. This is, for example, important for reducing cogging in electrical motors. Results of initial experiments involving use of the machine are presented. The functionality of the machine from a production standpoint and modifications of it that could be useful for mass production purposes, the properties of materials used for magnets, processes involved in manufacturing workpieces that are to be magnetized are discussed. Applications that can benefit from use of a machine of this type are compared with more traditional solutions.
|
|
| 4. |
|
|
| 5. |
- Gianni, Andrea, et al.
(författare)
-
Bainitic steel grade for solid wheels: metallurgical, mechanical and in-service testing
- 2007
-
Ingår i: Proceedings International Heavy Haul Association Specialist Technical Session (IHHA2007). ; , s. 701-711
-
Konferensbidrag (refereegranskat)abstract
- Bainitic steel grades generally have superior rolling contact and thermal fatigue resistances, but poorer wear characteristics as compared to “conventional” pearlitic steel wheels. To improve wear characteristics the manufacturing process of bainitic materials needs to be carefully controlled.In the current paper, the manufacturing process of the “MICRALOS” bainitic steel grade is described. The main focus is on metallurgical testing activities performed in order to compare the new steel grade to standard pearlitic steels and to predict service behaviour of the solid bainitic wheels. Further, on-going field tests on the iron-ore line between Luleå and Narvik are reported, with details about measurement methods and results.The performance of the wheels is reviewed and compared to the current scientific knowledge of bainitic steel grades and the deterioration of heavy haul wheels. Finally benefits of, and challenges for bainitic wheels in general and for the MICRALOS grade wheels in particular will be discussed.
|
|
| 6. |
- Gianni, Andrea, et al.
(författare)
-
Bainitic steel grade for solid wheels: metallurgical, mechanical, and in-service testing
- 2009
-
Ingår i: Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit. - 0954-4097 .- 2041-3017. ; 223:2, s. 163-171
-
Tidskriftsartikel (refereegranskat)abstract
- Bainitic steel grades generally have superior rolling contact and thermal fatigue resistances, but poorer wear characteristics when compared with ‘conventional’ pearlitic steel wheels. To improve the wear characteristics, the manufacturing process of bainitic materials needs to be carefully controlled. In this article, the manufacturing process of the ‘MICRALOS’ bainitic steel grade has been described. The main focus is on metallurgical testing activities performed in order to compare the new steel grade with standard pearlitic steels and to predict the service behaviour of the solid bainitic wheels. Further, on-going field tests on the iron ore line between Luleå and Narvik have been reported, with details about measurement methods and results. The performance of the wheels is reviewed and compared with the current scientific knowledge of bainitic steel grades and the deterioration of heavy haul wheels. Finally, benefits of and challenges for bainitic wheels in general and for the MICRALOS grade wheels in particular will be discussed.
|
|
| 7. |
- Giordanetto, Fabrizio, et al.
(författare)
-
Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists
- 2007
-
Ingår i: Bioorganic & Medicinal Chemistry Letters. - : Elsevier BV. - 0960-894X. ; 17:15, s. 4232-41
-
Tidskriftsartikel (refereegranskat)abstract
- We herein report the optimization of cyclopentane- and cyclohexane-1,3-diamine derivatives as novel and potent MCH-R1 antagonists. Structural modifications of the 2-amino-quinoline and thiophene moieties found in the initial lead compound served to improve its metabolic stability profile and MCH-R1 affinity, and revealed unprecedented SAR when compared to other 2-amino-quinoline-containing MCH-R1 antagonists.
|
|
| 8. |
- Holmquist Mengelbier, Linda, et al.
(författare)
-
Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.
- 2015
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- Genetic differences among neoplastic cells within the same tumour have been proposed to drive cancer progression and treatment failure. Whether data on intratumoral diversity can be used to predict clinical outcome remains unclear. We here address this issue by quantifying genetic intratumoral diversity in a set of chemotherapy-treated childhood tumours. By analysis of multiple tumour samples from seven patients we demonstrate intratumoral diversity in all patients analysed after chemotherapy, typically presenting as multiple clones within a single millimetre-sized tumour sample (microdiversity). We show that microdiversity often acts as the foundation for further genome evolution in metastases. In addition, we find that microdiversity predicts poor cancer-specific survival (60%; P=0.009), independent of other risk factors, in a cohort of 44 patients with chemotherapy-treated childhood kidney cancer. Survival was 100% for patients lacking microdiversity. Thus, intratumoral genetic diversity is common in childhood cancers after chemotherapy and may be an important factor behind treatment failure.
|
|
| 9. |
- Ichioka, Yuki, et al.
(författare)
-
Factors influencing outcomes of surgical therapy of peri-implantitis: A secondary analysis of 1-year results from a randomized clinical study
- 2023
-
Ingår i: JOURNAL OF CLINICAL PERIODONTOLOGY. - 0303-6979. ; 50:10, s. 1282-1304
-
Tidskriftsartikel (refereegranskat)abstract
- Aim: To identify predictors of treatment outcomes following surgical therapy of peri-implantitis.Materials and Methods: We performed a secondary analysis of data from a randomized controlled trial (RCT) comparing access flap with or without bone replacement graft. Outcomes at 12 months were probing pocket depth (PPD), bleeding on probing (BOP), soft-tissue recession (REC) and marginal bone level (MBL) change. Multilevel regression analyses were used to identify predictors. We also built an explanatory model for residual signs of inflammation.Results: Baseline PPD was the most relevant predictor, showing positive associations with final PPD, REC and MBL gain, and negative association with probability of pocket closure. Smokers presented higher residual PPD. Absence of keratinized mucosa at baseline increased the probability of BOP but was otherwise not indicative of outcomes. Plaque at 6 weeks was detrimental in terms of residual PPD and BOP. Treatment allocation had an effect on REC. Final BOP was explained by residual PPD & GE;6 mm and plaque at more than two sites.Conclusions: Baseline PPD was the most relevant predictor of the outcomes of surgical therapy of peri-implantitis. Pocket closure should be a primary goal of treatment. Bone replacement grafts may be indicated in aesthetically demanding cases to reduce soft-tissue recession. The importance of smoking cessation and patient-performed plaque control is also underlined.
|
|
| 10. |
- Ittner, Lars M, et al.
(författare)
-
Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells
- 2005
-
Ingår i: Journal of Biology. - : Springer Science and Business Media LLC. - 1475-4924. ; 4:11
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Development of the eye depends partly on the periocular mesenchyme derived from the neural crest (NC), but the fate of NC cells in mammalian eye development and the signals coordinating the formation of ocular structures are poorly understood. RESULTS: Here we reveal distinct NC contributions to both anterior and posterior mesenchymal eye structures and show that TGFbeta signaling in these cells is crucial for normal eye development. In the anterior eye, TGFbeta2 released from the lens is required for the expression of transcription factors Pitx2 and Foxc1 in the NC-derived cornea and in the chamber-angle structures of the eye that control intraocular pressure. TGFbeta enhances Foxc1 and induces Pitx2 expression in cell cultures. As in patients carrying mutations in PITX2 and FOXC1, TGFbeta signal inactivation in NC cells leads to ocular defects characteristic of the human disorder Axenfeld-Rieger's anomaly. In the posterior eye, NC cell-specific inactivation of TGFbeta signaling results in a condition reminiscent of the human disorder persistent hyperplastic primary vitreous. As a secondary effect, retinal patterning is also disturbed in mutant mice. CONCLUSION: In the developing eye the lens acts as a TGFbeta signaling center that controls the development of eye structures derived from the NC. Defective TGFbeta signal transduction interferes with NC-cell differentiation and survival anterior to the lens and with normal tissue morphogenesis and patterning posterior to the lens. The similarity to developmental eye disorders in humans suggests that defective TGFbeta signal modulation in ocular NC derivatives contributes to the pathophysiology of these diseases.
|
|
