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Sökning: WFRF:(Karström Alexandra)

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  • Karström, Alexandra, et al. (författare)
  • Keratinocytes
  • 2015. - 2
  • Ingår i: Guide to the quality and safety of tissues and cells for human application. - Strasbourg : Council of Europe Publishing. - 9789287181268 ; , s. 471-477
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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  • Ulfarsson, Elfar, et al. (författare)
  • Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells : A novel therapeutic approach
  • 2005
  • Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 11:13, s. 4674-4680
  • Tidskriftsartikel (refereegranskat)abstract
    • Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children. In many cases, the patients acquire growth hormone deficiency and postoperatively need substitution. Generally, growth hormone promotes local release of insulin-like growth factor I (IGF-I), which in turn activates the IGF-I receptor (IGF-IR) if present. Together, these circumstances raise the question whether IGF-IR may be involved in craniopharyngioma growth. To address this issue, we analyzed phenotypically well-characterized primary low-passage craniopharyngioma cell lines from nine different patients for IGF-IR expression and IGF-I dependency. Two of the cell lines showed no/very low expression of the receptor and was independent on IGF-I, whereas five cell lines exhibited a strong expression and was clearly contingent on IGF-I. The two remaining cell lines had low receptor expression and IGF-I dependency. Upon treatment with an IGF-IR inhibitor, cells with high IGF-IR expression responded promptly with decreased Akt phosphorylation followed by growth arrest. These responses were not seen in cells with no/very low receptor expression. Growth of cell lines with tow IGF-IR expression was only slightly affected by IGF-IR inhibition. Taken together, our data suggest that IGF-IR may be involved in the growth of a subset of craniopharyngiomas and points to the possibility of the involvement of IGF-IR inhibitors as a treatment modality to obtain complete tumor-free conditions before growth hormone substitution. © 2005 American Association for Cancer Research.
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