| 1. |
- Aad, G., et al.
(författare)
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- 2015
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Ingår i: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368 .- 1550-7998. ; 91:5
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Chickarmane, Vijay, et al.
(författare)
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Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility
- 2009
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Ingår i: PLoS Computational Biology. - : Public Library of Science (PLoS). - 1553-7358. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Hematopoietic stem cell lineage choices are decided by genetic networks that are turned ON/OFF in a switch-like manner. However, prior to lineage commitment, genes are primed at low expression levels. Understanding the underlying molecular circuitry in terms of how it governs both a primed state and, at the other extreme, a committed state is of relevance not only to hematopoiesis but also to developmental systems in general. We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. Dynamical models based upon known interactions between these master genes, such as mutual antagonism and autoregulation, fail to make the system bistable, a desired feature for robust lineage determination. We therefore suggest a new mechanism involving a cofactor that is regulated as well as recruited by one of the master genes to bind to the antagonistic partner that is necessary for bistability and hence switch-like behavior. An interesting fallout from this architecture is that suppression of the cofactor through external means can lead to a loss of cooperativity, and hence to a primed state for PU.1 and GATA-1. The PU. 1-GATA-1 switch also interacts with another mutually antagonistic pair, C/EBP alpha-FOG-1. The latter pair inherits the state of its upstream master genes and further reinforces the decision due to several feedback loops, thereby leading to irreversible commitment. The genetic switch, which handles the erythroid-myeloid lineage decision, is an example of a network that implements both a primed and a committed state by regulating cooperativity through recruitment of cofactors. Perturbing the feedback between the master regulators and downstream targets suggests potential reprogramming strategies. The approach points to a framework for lineage commitment studies in general and could aid the search for lineage-determining genes.
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| 3. |
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| 4. |
- Hedberg, Hans, et al.
(författare)
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BOP
- 2012
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Ingår i: Fotografins hus.
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Konstnärligt arbete (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Holmberg, Christopher, 1984, et al.
(författare)
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Clinical validity of the 12-item WHODAS-2.0 in a naturalistic sample of outpatients with psychotic disorders
- 2021
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Ingår i: BMC Psychiatry. - : Springer Science and Business Media LLC. - 1471-244X. ; 21:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS-2.0) is a self-administered instrument to assess functional impairment. It is used in the general population as well as different patient groups. However, its application to patients with psychotic disorders may be hampered by disease-specific difficulties of self-estimation. This study aimed to examine the psychometric properties of the short (12-item) WHODAS-2.0 in a naturalistic sample of outpatients attending a psychosis clinic in Gothenburg, Sweden. Methods: Annual data from two outpatient clinics registered 2016–2019 were analyzed retrospectively. The assessment of the short WHODAS-2.0 was based on the first questionnaire completed by 881 patients. Confirmatory factor analysis evaluated previously validated models. Item convergent and discriminant validity as well as internal reliability were computed. Construct validity was assessed by comparing mean differences in accord with previous research regarding patients’ characteristics associated with functioning such as advanced age, diagnosed comorbidities, antipsychotic treatment status, and symptom severity measured with PANSS-8 remission items. Results: A heterogeneous sample was obtained in terms of age (range: 20–92), various living situations, and different geographic areas of birth. Most patients (75%) had been diagnosed with psychotic disorders more than 10 years ago and the majority (89%) were on antipsychotic medication. We confirmed an adjusted two-level factor model with a single second-order disability factor and six first-order factors representing the six IFC dimensions. The WHODAS-2.0 sum score measuring general disability showed good reliability (Cronbach's alpha = 0.89). Construct validity was confirmed as older patients, patients with comorbidities, and patients in assisted living had higher WHODAS-2.0 scores. Patients with no or mild psychotic symptoms had significantly lower WHODAS-2.0 sum scores than patients with more severe symptoms. Conclusions: The findings further validate the 12-item WHODAS-2.0 in a naturalistic sample of outpatients with psychotic disorders. This study corroborates the clinical significance of the short, 12-item WHODAS-2.0 by demonstrating consistent associations between patients’ age, medical comorbidities, living situation, antipsychotic treatment status, and psychotic symptom severity.
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| 6. |
- Holmberg, Christopher, 1984
(författare)
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Conducting Mixed-Methods Research in the Mental Health Care Setting: A Study Exploring Job Satisfaction Among Nursing Personnel
- 2019
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Ingår i: SAGE Research Methods Cases. - London : SAGE Publications Ltd.. - 9781526479921
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The aim of the study that this method case builds on was to explore job satisfaction among mental health nursing personnel. Because I wanted to identify and quantify the factors that influenced the nursing personnel’s job satisfaction, as well as explore how the personnel experienced these factors, a mixed-methods approach was used. The quantitative findings were drawn from a cross-sectional questionnaire, and the qualitative analysis was conducted using data collected from individual interviews. Using mixed methods allows for the triangulation of quantitative and qualitative findings for gaining greater validity and completeness. However, the approach is somewhat demanding as it is resource-intensive. It is therefore important to justify the relevance for using such an approach. Thus, in this method case, I will justify my use of this method to answer the research questions and explicate the rationale for selecting the specific design. Finally, this case study includes a discussion of the practical lessons learned from the implementation experiences, which includes a reflection regarding my role as a clinical researcher in my dual capacity as both a clinician and a researcher.
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| 7. |
- Kaun, Anne, 1983-, et al.
(författare)
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Politisera, sociologisera, historisera AI!
- 2018. - 1
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Ingår i: Människor och AI. - Stockholm : Books on Demand. - 9789178517213 - 9789177854043 ; , s. 48-56
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Bokkapitel (populärvet., debatt m.m.)
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| 8. |
- Kaun, Anne, 1983-, et al.
(författare)
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Prison Media : Incarceration and the Infrastructures of Work and Technology
- 2023
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Bok (refereegranskat)abstract
- How prisoners serve as media laborers, while the prison serves as a testing ground for new media technologies.Prisons are not typically known for cutting-edge media technologies. Yet from photography in the nineteenth century to AI-enhanced tracking cameras today, there is a long history of prisons being used as a testing ground for technologies that are later adopted by the general public. If we recognize the prison as a central site for the development of media technologies, how might that change our understanding of both media systems and carceral systems? Prison Media foregrounds the ways in which the prison is a model space for the control and transmission of information, a place where media is produced, and a medium in its own right.Examining the relationship between media and prison architecture, as surveillance and communication technologies are literally built into the facilities, this study also considers the ways in which prisoners themselves often do hard labor as media workers—labor that contributes in direct and indirect ways to the latest technologies developed and sold by multinational corporations like Amazon. There is a fine line between ankle monitors and Fitbits, and Prison Media helps us make sense of today's carceral society.
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| 9. |
- Kaun, Anne, 1983-, et al.
(författare)
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Prison media work : from manual labor to the work of being tracked
- 2020
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Ingår i: Media Culture and Society. - : Sage Publications. - 0163-4437 .- 1460-3675. ; 42:7-8, s. 1277-1292
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Tidskriftsartikel (refereegranskat)abstract
- Incarcerated individuals have long contributed to crucial societal infrastructures. Frombeing leased work force building the railway in the United States to constructing canalsystems in Sweden, prisoners’ labor has been widespread as an important part ofvalue production. Part of the labor conducted by incarcerated people is related tothe production, repair, and maintenance of media devices and media infrastructuresconstituting what we call prison media work. In this article, we trace the changinglogics of prison media work historically since the inception of the modern prison at theturn of the 20th century. Based on archival material, interviews, and field observations,we outline a shift from physical manual labor toward the work of being tracked thatis constitutive of surveillance capitalism in- and outside of the prison. We argue thatprison media work holds an ambiguous position combining elements of exploitationand rehabilitation, but most importantly it is a dystopian magnifying glass of media workunder surveillance capitalism.
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| 10. |
- Kaun, Anne, 1983-, et al.
(författare)
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Prison Tech : Imagining the Prison as Lagging Behind and as a Test Bed for Technology Advancement
- 2021
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Ingår i: Communication, Culture & Critique. - : Oxford University Press. - 1753-9129 .- 1753-9137. ; 15:1, s. 69-83
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Tidskriftsartikel (refereegranskat)abstract
- This article explores the ways in which prisons are imagined as sites of technology development. By attending to expos that showcase prison technologies and constitute “live theatres of technology” (L. Cornfeld, 2018), we carve out ambivalent sociotechnical imaginaries of technological backwardness that are combined with the idea of radical technological innovation to reform the justice system. In doing so, we highlight the prison as one site of technology development and actors at technology trade shows catering to the prison and security sector as platforms for technological mediators that range from corporate prison tech companies to educators as well as representatives of the criminal justice system. The expos emerge as sites where technological development is negotiated through performative sociotechnical imaginaries of prison tech.
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