SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Kaya Ibrahim) "

Sökning: WFRF:(Kaya Ibrahim)

  • Resultat 1-10 av 32
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Glasbey, JC, et al. (författare)
  • 2021
  • swepub:Mat__t
  •  
2.
  •  
3.
  • 2021
  • swepub:Mat__t
  •  
4.
  • Bravo, L, et al. (författare)
  • 2021
  • swepub:Mat__t
  •  
5.
  • Tabiri, S, et al. (författare)
  • 2021
  • swepub:Mat__t
  •  
6.
  •  
7.
  •  
8.
  • 2021
  • swepub:Mat__t
  •  
9.
  • Baijnath, Sooraj, et al. (författare)
  • Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics
  • 2022
  • Ingår i: TIPS - Trends in Pharmacological Sciences. - : Elsevier. - 0165-6147 .- 1873-3735. ; 43:9, s. 740-753
  • Forskningsöversikt (refereegranskat)abstract
    • Mass spectrometry imaging (MSI) is a powerful technique that combines the abil-ity of microscopy to provide spatial information about multiple molecular species with the specificity of mass spectrometry (MS) for unlabeled mapping of analytes in diverse biological tissues. Initial pharmacological applications focused on drug distributions in different organs, including the compartmentalized brain. However, recent technological advances in instrumentation, software, and chemical tools have allowed its use in quantitative spatial omics. It now enables visualization of distributions of diverse molecules at high lateral resolution in studies of the pharmacokinetic and neuropharmacodynamic effects of drugs on functional biomolecules. Therefore, it has become a versatile technique with a multitude of applications that have transformed neuropharmacological re-search and enabled research into brain physiology at unprecedented resolution, as described in this review.
  •  
10.
  • Berglund, Sigrid, et al. (författare)
  • Hydrogen production by a fully de novo enzyme
  • 2024
  • Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
    • Molecular catalysts based on abundant elements that function in neutral water represent an essential component of sustainable hydrogen production. Artificial hydrogenases based on protein-inorganic hybrids have emerged as an intriguing class of catalysts for this purpose. We have prepared a novel artificial hydrogenase based on cobaloxime bound to a de novo three alpha-helical protein, α3C, via a pyridyl-based unnatural amino acid. The functionalized de novo protein was characterised by UV-visible, CD, and EPR spectroscopy, as well as MALDI spectrometry, which confirmed the presence and ligation of cobaloxime to the protein. The new de novo protein produced hydrogen under electrochemical, photochemical and reductive chemical conditions in neutral water solution. A change in hydrogen evolution capability of the de novo enzyme compared with native cobaloxime was observed, with turnover numbers around 80% of that of cobaloxime, and hydrogen evolution rates of 40% of that of cobaloxime. We discuss these findings in the context of existing literature, how our study contributes important information about the functionality of cobaloxime as hydrogen evolving catalysts in protein environments, and the feasibility of using de novo proteins for developent into artificial metalloenzymes. Small de novo proteins as enzyme scaffolds have the potential to function as upscalable bioinspired catalysts thanks to their efficient atom economy, and the findings presented here show that these types of novel enzymes are a possible product. 
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 32

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy