| 1. |
- Bousquet, J., et al.
(författare)
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Building Bridges for Innovation in Ageing : Synergies between Action Groups of the EIP on AHA
- 2017
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Ingår i: The Journal of Nutrition, Health & Aging. - : Springer Nature. - 1279-7707 .- 1760-4788. ; 21:1, s. 92-104
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Tidskriftsartikel (refereegranskat)abstract
- The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).
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| 2. |
- Fluitman, Kristina S., et al.
(författare)
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The Association of Olfactory Function with BMI, Appetite, and Prospective Weight Change in Dutch Community-Dwelling Older Adults
- 2019
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Ingår i: Journal of Nutrition Health & Aging. - : Springer Science and Business Media LLC. - 1279-7707 .- 1760-4788. ; 23:8, s. 746-752
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: The olfactory decline that often accompanies aging is thought to contribute to undernutrition in older adults. It is believed to negatively affect eating pleasure, appetite, food intake and subsequently nutritional status. We have evaluated the associations of olfactory function with BMI, appetite and prospective weight change in a cohort of Dutch community-dwelling older adults. Design Cross-sectional cohort study. Participants Dutch community-dwelling older adults from the ongoing Longitudinal Aging Study Amsterdam (LASA). Measurements and setting In 2012-2013, the 40-item University of Pennsylvania Smell Identification Test (UPSIT) was administered to 824 LASA participants to evaluate their olfactory function. Body weight, height, appetite, comorbidity, cognitive status and socio-demographic factors were also assessed. Follow-up weight was measured after three years. Results 673 participants (aged 55-65 years) were included in the regression analyses. Median UPSIT-score was 33. When adjusted for potential confounders, lower UPSIT-score (indicative of poorer olfactory function) was not associated with poor appetite (OR = 1.062, p = 0.137) or prospective weight change (B = -0.027, p = 0.548). It was, however, associated with lower BMI in smokers (B = 0.178, p = 0.032), but not in non-smokers (B = -0.015, p = 0.732). Conclusion Lower olfactory function scores were associated with lower BMI in community-dwelling older adults who smoke, but not with appetite or prospective weight change. Therefore, smoking older adults with olfactory impairments may pose as a vulnerable group with respect to developing undernutrition.
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| 3. |
- Keijser, Rebecka, 1984-
(författare)
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Depressive Symptoms Among Adolescents and Young Adults : Psychometrics and the Influence of Family Environment, and Candidate Gene–environment Interactions
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The overall aims of this thesis were to evaluate the psychometric properties of a questionnaire designed to evaluate parenting styles, and to study how depressive symptoms among adolescents and young adults may vary depending on the family environment and candidate gene–environment interaction (cG×E).The study sample consisted of participants (born during 1997 or 1999), and their caregivers from the Survey of Adolescent Life in Västmanland Cohort Study. This thesis included data from 2012 when the participants were 13 and 15 years old (Wave I: DNA collection), 2015 at ages 16 and 18 years (Wave II: Parenting styles, parental depression, depressive symptoms, early life stress i.e., ELS) and 2018 at ages 19 and 21 years (Wave III: Depressive symptoms).Paper I: A good model fit was obtained for the Parent as Social Context Questionnaire (PASCQ) parent and adolescent versions through psychometric evaluations. Paper II: Positive and negative parenting styles were associated with fewer or more depressive symptoms among adolescents and young adults, respectively. Parental depression×sex was associated with more depressive symptoms, preponderant among female adolescents. The findings were not significant among young adults. Paper III: A significant cG×E effect between oxytocin receptor single-nucleotide polymorphism (SNP) rs6770632 and negative parenting style on depressive symptoms among young adults was found. Paper IV: Significant cG×E effects were found for the FKBP5 SNPs rs1360780, rs4713916, rs7748266 and rs9394309 moderated by ELS and positive parenting style on depressive symptoms among young adults.These findings suggest that parenting styles may be measured with the PASCQ and that depressive symptoms among adolescents and young adults seem to vary dependent on the family environment and cG×E effects. However, the cG×E effects may be more central for some individuals depending on differences in diathesis- or sensitivity towards the family environment. The variance in depressive symptoms may therefore contain diathesis stress and differential susceptibility effects regarding the cG×E interaction. The insight gained from this thesis provides a foundation for future research and contributes to research areas such as parenting research and the understanding of biological factors behind depressive symptomology among adolescents and young adults.
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| 4. |
- Keijser, Rebecka, et al.
(författare)
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Gene–environment interaction : Oxytocin receptor (OXTR) polymorphisms and parenting style as potential predictors for depressive symptoms
- 2021
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Ingår i: Psychiatry Research. - : Elsevier Ireland Ltd. - 0165-1781 .- 1872-7123. ; 303
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Tidskriftsartikel (refereegranskat)abstract
- Depression is a common mental health problem that is thought to develop through a combination of genetic, psychological, and environmental factors, including parental behaviours and parental mental health. The present study investigated the potential interaction between oxytocin receptor (OXTR) single nucleotide polymorphisms (SNPs) (rs53576, rs237880, rs237887, rs237889, rs237898, rs1042778, rs2268490, rs2268491, rs4686302, rs6770632, rs13316193) and parenting style in adolescence in relation to depressive symptoms among young adults. The sample consisted of 1,098 Caucasian participants (63.6% females) and their parents. The present study included data from the Survey of Adolescent Life Cohort study collected in 2012 at wave I (mage 14.4 years; DNA collection), 2015 at wave II (mage 17.36 years; Estimation of parenting style, depressive symptoms, and parental depression) and 2018 at wave III (mage 20.19 years; Depressive symptoms). Evidence for an interaction effect between OXTR SNP rs6770632 and negative parenting style on depressive symptoms among young adults was found with support for the diathesis–stress theory. The rs6770632 was associated with depressive symptoms at higher levels of negative parenting, with A:A allele carriers reporting higher levels of depressive symptoms than C:C and C:A allele carriers. The present study provides preliminary knowledge about the potential moderation effects of perceived negative parenting on the effect of OXTR SNPs on depressive symptoms among young adults, independent of sex, previous reports of depressive symptoms, and parental depression.
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| 5. |
- Keijser, Rebecka, et al.
(författare)
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Measuring parental dimensions : A psychometric evaluation of the parents as social context questionnaire, Swedish version
- 2020
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Ingår i: Cogent Psychology. - : TAYLOR & FRANCIS AS. - 2331-1908. ; 7:1
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Tidskriftsartikel (refereegranskat)abstract
- The relationship between a parent and an adolescent is dynamic. A parent may do better in certain areas or during certain phases of the adolescent's life, and the adolescent's needs or demands on the parent may vary accordingly. Parental dimensions have been used to evaluate the quality of a parent-child relationship. The present study explored the structure of a translated version of the Parents as Social Context Questionnaire (PASCQ), both a parent and an adolescent version. The participants were 1556 Swedish adolescents 16-18 years (mean age = 17.4 years, 58.3% females), and 1477 parents, including 1345 parent-adolescent dyads. The results of the confirmatory factor analyses provided a significant model fit of the six parental dimensions (Warmth, Rejection, Structure, Chaos, Autonomy support and Coercion) of PASCQ regarding both the parent- and adolescent reports. Therefore, the Swedish version of the PASCQ parent and adolescent reports is suitable for measuring the six parental dimensions of the PASCQ. However, the concordance between the two reports was low, suggesting that the parent report may be suitable for measuring the parent's view of the relationship, but may be less representative of the adolescent's experiences and vice versa. These results can contribute to future work on parenting in general and parental dimensions in association with adolescents in particular.
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| 6. |
- Keijser, Rebecka, et al.
(författare)
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The influence of parenting styles and parental depression on adolescent depressive symptoms : A cross-sectional and longitudinal approach
- 2020
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Ingår i: Mental Health and Prevention. - : Elsevier GmbH. - 2212-6570. ; 20
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Tidskriftsartikel (refereegranskat)abstract
- Background: Depression often emerges during early adolescence and is one of the most common mental health problems. The present study investigated the influence of parenting styles and parental depression on depressive symptoms during adolescence and young adulthood, using both a cross-sectional and a longitudinal approach. Methods: Data were obtained from the Survey of Adolescent Life in Västmanland Cohort study and comprised 1603 adolescents who completed questionnaires at two time points (ages 16–18 and ages 19–21). Results: In the cross-sectional approach, a positive parenting style (Warmth, Structure, Autonomy support) was associated with less depressive symptoms, and a negative parenting style (Rejection, Chaos, Coercion) and parental depression were associated with more depressive symptoms in 16–18-year-old adolescents. The effect of parental depression was stronger among adolescent females. In the longitudinal approach, a protective effect was found, where a positive parenting style at adolescent ages 16–18 was associated with less depressive symptoms at ages 19–21, even when controlling for initial depressive symptomatology. Conclusions: These findings may make an important contribution to treatment programmes and family-based prevention strategies related to adolescent depressive symptomatology, particularly regarding the potential long-term protective effects of positive parenting style in middle and late adolescence. © 2020
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| 7. |
- Keijser, Rebecka, et al.
(författare)
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Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population
- 2021
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Ingår i: Journal of neural transmission. - : Springer Nature. - 0300-9564 .- 1435-1463. ; 128, s. 1409-1424
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Tidskriftsartikel (refereegranskat)abstract
- FKBP5 gene–environment interaction (cG × E) studies have shown diverse results, some indicating significant interaction effects between the gene and environmental stressors on depression, while others lack such results. Moreover, FKBP5 has a potential role in the diathesis stress and differential susceptibility theorem. The aim of the present study was to evaluate whether a cG × E interaction effect of FKBP5 single-nucleotide polymorphisms (SNPs) or haplotype and early life stress (ELS) on depressive symptoms among young adults was moderated by a positive parenting style (PASCQpos), through the frameworks of the diathesis stress and differential susceptibility theorem. Data were obtained from the Survey of Adolescent Life in Västmanland Cohort Study, including 1006 participants and their guardians. Data were collected during 2012, when the participants were 13 and 15 years old (Wave I: DNA), 2015, when participants were 16 and 18 years old (Wave II: PASCQpos, depressive symptomology and ELS) and 2018, when participants were 19 and 21 years old (Wave III: depressive symptomology). Significant three-way interactions were found for the FKBP5 SNPs rs1360780, rs4713916, rs7748266 and rs9394309, moderated by ELS and PASCQpos, on depressive symptoms among young adults. Diathesis stress patterns of interaction were observed for the FKBP5 SNPs rs1360780, rs4713916 and rs9394309, and differential susceptibility patterns of interaction were observed for the FKBP5 SNP rs7748266. Findings emphasize the possible role of FKBP5 in the development of depressive symptoms among young adults and contribute to the understanding of possible differential susceptibility effects of FKBP5.
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