| 1. |
- Amole, C., et al.
(författare)
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The ALPHA antihydrogen trapping apparatus
- 2014
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Ingår i: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 735, s. 319-340
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Tidskriftsartikel (refereegranskat)abstract
- The ALPHA collaboration, based at CERN, has recently succeeded in confining cold antihydrogen atoms in a magnetic minimum neutral atom trap and has performed the first study of a resonant transition of the anti-atoms. The ALPHA apparatus will be described herein, with emphasis on the structural aspects, diagnostic methods and techniques that have enabled antihydrogen trapping and experimentation to be achieved.
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| 2. |
- Charlton, M, et al.
(författare)
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Antiparticle sources for antihydrogen production and trapping
- 2011
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6596. ; 262, s. 012001-
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Tidskriftsartikel (refereegranskat)abstract
- Sources of positrons and antiprotons that are currently used for the formation of antihydrogen with low kinetic energies are reviewed, mostly in the context of the ALPHA collaboration and its predecessor ATHENA. The experiments were undertaken at the Antiproton Decelerator facility, which is located at CERN. Operations performed on the clouds of antiparticles to facilitate their mixing to produce antihydrogen are described. These include accumulation, cooling and manipulation. The formation of antihydrogen and some of the characteristics of the anti-atoms that are created are discussed. Prospects for trapping antihydrogen in a magnetic minimum trap, as envisaged by the ALPHA collaboration, are reviewed.
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| 3. |
- Ariens, Robert, et al.
(författare)
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Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress
- 2020
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Ingår i: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS. - : Wiley. - 2475-0379. ; 4:5, s. 680-713
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Forskningsöversikt (refereegranskat)abstract
- The 2020 Congress of the International Society of Thrombosis and Haemostasis (ISTH) was held virtually July 12-15, 2019, due to the coronavirus disease 2019 pandemic. The congress convenes annually to discuss clinical and basic topics in hemostasis and thrombosis. Each year, the program includes State of Art (SOA) lectures given by prominent scientists. Presenters are asked to create Illustrated Capsules of their talks, which are concise illustrations with minimal explanatory text. Capsules cover major themes of the presentation, and these undergo formal peer review for inclusion in this article. Owing to the shift to a virtual congress this year, organizers reduced the program size. There were 39 SOA lectures virtually presented, and 29 capsules (9 from talks omitted from the virtual congress) were both submitted and successful in peer review, and are included in this article. Topics include the roles of the hemostatic system in inflammation, infection, immunity, and cancer, platelet function and signaling, platelet function disorders, megakaryocyte biology, hemophilia including gene therapy, phenotype tests in hemostasis, von Willebrand factor, anticoagulant factor V, computational driven discovery, endothelium, clinical and basic aspects of thrombotic microangiopathies, fibrinolysis and thrombolysis, antithrombotics in pediatrics, direct oral anticoagulant management, and thrombosis and hemostasis in pregnancy. Capsule authors invite virtual congress attendees to refer to these capsules during the live presentations and participate on Twitter in discussion. Research and Practice in Haemostasis and Thrombosis will release 2 tweets from @RPTHJournal during each presentation, using #IllustratedReview, #CoagCapsule and #ISTH2020. Readers are also welcome to utilize capsules for teaching and ongoing education.
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| 4. |
- Gepner, B. D., et al.
(författare)
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Comparison of human body models in frontal crashes with reclined seatback
- 2019
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Ingår i: Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI. - 2235-3151. ; , s. 293-307
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Konferensbidrag (refereegranskat)abstract
- Reclined seating configurations, relevant to the future of Autonomous Driving Systems is likely to challenge the current state-of-the-art restraint systems. Human body models (HBM) offer an attractive tool to support the design process, however their validity in the reclined scenario remains questionable. The goal of this study is to compare the response of selected HBMs in the frontal, reclined scenario, while utilizing a new prototype restraint system. A sled model with a generic seat, 50 deg seatback recline angle and a prototype 3-point belt system was used in this study. Four different male HBMs were compared, the Global Human Body Model Consortium (GHBMC) simplified occupant model (GHBMC-S), the GHBMC detailed model (GHBMC-D), Total Human Model for Safety SAFER (THUMS-S) model, and THUMS-v5 model. All HBMs showed good pelvis engagement, except GHBMC-D that submarined under the lap belt. Additionally, large differences were observed in pelvis and lumbar spine response between GHBMC and THUMS family models. Since no relevant PMHS data is currently available, it is impossible to evaluate the biofidelity of these models in the reclined scenarios. Evaluating the relative biofidelity of these models can only be accomplished with experimental data capturing detailed 3D skeletal kinematics and all the boundary forces necessary for model evaluation.
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| 5. |
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| 6. |
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| 7. |
- Fang, Li Tai, et al.
(författare)
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Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing
- 2021
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Ingår i: Nature Biotechnology. - : Springer Nature. - 1087-0156 .- 1546-1696. ; 39:9, s. 1151-1160
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Tidskriftsartikel (refereegranskat)abstract
- Tumor-normal paired DNA samples from a breast cancer cell line and a matched lymphoblastoid cell line enable calibration of clinical sequencing pipelines and benchmarking 'tumor-only' or 'matched tumor-normal' analyses. The lack of samples for generating standardized DNA datasets for setting up a sequencing pipeline or benchmarking the performance of different algorithms limits the implementation and uptake of cancer genomics. Here, we describe reference call sets obtained from paired tumor-normal genomic DNA (gDNA) samples derived from a breast cancer cell line-which is highly heterogeneous, with an aneuploid genome, and enriched in somatic alterations-and a matched lymphoblastoid cell line. We partially validated both somatic mutations and germline variants in these call sets via whole-exome sequencing (WES) with different sequencing platforms and targeted sequencing with >2,000-fold coverage, spanning 82% of genomic regions with high confidence. Although the gDNA reference samples are not representative of primary cancer cells from a clinical sample, when setting up a sequencing pipeline, they not only minimize potential biases from technologies, assays and informatics but also provide a unique resource for benchmarking 'tumor-only' or 'matched tumor-normal' analyses.
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| 8. |
- Gangannagaripalli, J., et al.
(författare)
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A Standard Set of Value-Based Patient-Centered Outcomes and Measures of Overall Health in Adults
- 2022
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Ingår i: Patient-Patient Centered Outcomes Research. - : Springer Science and Business Media LLC. - 1178-1653 .- 1178-1661. ; 15:3, s. 341-351
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Tidskriftsartikel (refereegranskat)abstract
- Background The definition of population-specific outcomes is an essential precondition for the implementation of value-based health care. We developed a minimum standard outcome set for overall adult health (OAH) to facilitate the implementation of value-based health care in tracking, comparing, and improving overall health care outcomes of adults across multiple conditions, which would be of particular relevance for primary care and public health populations. Methods The International Consortium for Health Outcomes Measurement (ICHOM) convened an international panel (patients, clinicians, and topic experts). Following the development of a conceptual framework, a modified Delphi method (supported by public consultations) was implemented to identify, in sequence, the relevant domains, the best instruments for measuring them, the timing of measurement, and the relevant adjustment variables. Findings Outcomes were identified in relation to overall health status and the domains of physical, mental, and social health. Three instruments covering these domains were identified: PROMIS Scale v1.2-Global Health (10 items), WHO Wellbeing Index (5 items), and the WHO Disability Assessment Schedule 2.0 (12 items). Case-mix variables included a range of sociodemographic and biometric measures. Yearly measurement was proposed for all outcomes and most case-mix variables. Interpretation The ICHOM OAH Standard Set has been developed through consensus-based methods based on predefined criteria following high standards for the identification and selection of high-quality measures The involvements of a wide range of stakeholders supports the acceptability of the set, which is readily available for use and feasibility testing in clinical settings.
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| 9. |
- Gepner, B. D., et al.
(författare)
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Evaluation of GHBMC, THUMS and SAFER Human Body Models in Frontal Impacts in Reclined Postures
- 2022
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Ingår i: Conference proceedings International Research Council on the Biomechanics of Injury, IRCOBI. - 2235-3151. ; 2022-September, s. 116-143
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Konferensbidrag (refereegranskat)abstract
- Virtual tools, such as human body models (HBMs), can support advances in vehicle development and restraint system design. The goal of this study is to evaluate selected HBMs against data from recent reclined post-mortem human subject (PMHS) tests. Three HBMs - the Global Human Body Modelling Consortium detailed model v.6.0, Total Human Model for Safety v.6.0, and SAFER HBM v.10 - were used in this study. The models were positioned with respect to the average PMHS position and utlised a previously developed environment model. The HBMs were evaluated comparing belt engagement, boundary forces and displacements (in the seat and belt), and the trajectories of the head, T1, T8, T11, L1, L3, and pelvis. The HBMs' belt engagement, boundary forces and displacements, and X-direction (fore-aft) trajectories were all generally consistent with the PMHS. All HBMs predicted more downward motion of the head and T1 compared to the PMHS. The HBMs also showed rearward pelvis pitch at peak lap belt force, opposite to the PMHS. Some of these differences were associated with differences in flexion of the lumbar spine. This is the first study to provide an in-depth evaluation of multiple reclined HBMs in frontal crashes compared to reclined PMHS.
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| 10. |
- Goodfellow, IG, et al.
(författare)
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Inhibition of coxsackie B virus infection by soluble forms of its receptors: Binding affinities, altered particle formation, and competition with cellular receptors
- 2005
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Ingår i: Journal of Virology. - 1098-5514. ; 79:18, s. 12016-12024
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Tidskriftsartikel (refereegranskat)abstract
- We previously reported that soluble decay-accelerating factor (DAF) and coxsackievirus-adenovirus receptor (CAR) blocked coxsackievirus 133 (CVB3) myocarditis in mice, but only soluble CAR blocked CVB3-mediated pancreatitis. Here, we report that the in vitro mechanisms of viral inhibition by these soluble receptors also differ. Soluble DAF inhibited virus infection through the formation of reversible complexes with CVB3, while binding of soluble CAR to CVB induced the formation of altered (A) particles with a resultant irreversible loss of infectivity. A-particle formation was characterized by loss of VP4 from the virions and required incubation of CVB3-CAR complexes at 37 degrees C. Dimeric soluble DAF (DAF-Fc) was found to be 125-fold-more effective at inhibiting CVB3 than monomeric DAF, which corresponded to a 100-fold increase in binding affinity as determined by surface plasmon resonance analysis. Soluble CAR and soluble dimeric CAR (CAR-Fc) bound to CVB3 with 5,000- and 10,000-fold-higher affinities than the equivalent forms of DAF. While DAF-Fc was 125-fold-more effective at inhibiting virus than monomeric DAF, complement regulation by DAF-Fc was decreased 4 fold. Therefore, while the virus binding was a cooperative event, complement regulation was hindered by the molecular orientation of DAF-Fc, indicating that the regions responsible for complement regulation and virus binding do not completely overlap. Relative contributions of CVB binding affinity, receptor binding footprint on the virus capsid, and induction of capsid conformation alterations for the ability of cellular DAF and CAR to act as receptors are discussed.
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