| 1. |
- Galkina, Olga, et al.
(författare)
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Antibacterial and photochemical properties of cellulose nanofiber-titania nanocomposites loaded with two different types of antibiotic medicines
- 2015
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Ingår i: Journal of materials chemistry. B. - : Royal Society of Chemistry (RSC). - 2050-750X .- 2050-7518. ; 3:35, s. 7125-7134
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Tidskriftsartikel (refereegranskat)abstract
- Nanocomposite dermal drug delivery systems based on cellulose nanofibers with grafted titania nanoparticles loaded by two antibiotic medicines from different classes, i.e. tetracycline (TC) and phosphomycin (Phos), were successfully produced by a "green chemistry'' approach in aqueous media. The influence of a different surface binding mechanism between the drug molecule and modified cellulose nanofibers on the release of the drug and, as a result, on antimicrobial properties against common pathogens Gram-positive, Staphylococcus aureus and Gram-negative Escherichia coli was investigated. The disk diffusion method and broth culture tests using varying concentrations of drugs loaded to nanocomposites were carried out to investigate the antibacterial effects. The influence of UV irradiation on the stability of the obtained nanocomposites and their antibacterial properties after irradiation were also investigated, showing enhanced stability especially for the TC loaded materials. These findings suggest that the obtained nanocomposites are promising materials for the development of potentially useful antimicrobial patches.
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| 2. |
- Agback, Peter, et al.
(författare)
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Site-specific recognition of SARS-CoV-2 nsp1 protein with a tailored titanium dioxide nanoparticle - elucidation of the complex structure using NMR data and theoretical calculation
- 2022
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Ingår i: Nanoscale advances. - : Royal Society of Chemistry (RSC). - 2516-0230. ; 4, s. 1527-1532
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Tidskriftsartikel (refereegranskat)abstract
- The ongoing world-wide Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic shows the need for new potential sensing and therapeutic means against the CoV viruses. The SARS-CoV-2 nsp1 protein is important, both for replication and pathogenesis, making it an attractive target for intervention. In this study we investigated the interaction of this protein with two types of titania nanoparticles by NMR and discovered that while lactate capped particles essentially did not interact with the protein chain, the aminoalcohol-capped ones showed strong complexation with a distinct part of an ordered alpha-helix fragment. The structure of the forming complex was elucidated based on NMR data and theoretical calculation. To the best of our knowledge, this is the first time that a tailored titanium oxide nanoparticle was shown to interact specifically with a unique site of the full-length SARS-CoV-2 nsp1 protein, possibly interfering with its functionality.
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| 3. |
- Ahniyaz, Anwar, et al.
(författare)
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Preparation of iron oxide nanocrystals by surfactant-free or oleic acid-assisted thermal decomposition of a Fe(III) alkoxide
- 2008
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Ingår i: Journal of Magnetism and Magnetic Materials. - : Elsevier BV. - 0304-8853 .- 1873-4766. ; 320:6, s. 781-787
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Tidskriftsartikel (refereegranskat)abstract
- A new non-hydrolytic, alkoxide-based route was developed to synthesize iron oxide nanocrystals. Surfactant-free thermal decomposition of the iron 2-methoxy-ethoxide precursors results in the formation of uniform iron oxide nanocrystals with an average size of 5.6 nm. Transmission electron microscope study shows that the nanocrystals are protected against aggregation by a repulsive surface layer, probably originating from the alkoxy-alkoxide ligands. Addition of oleic acid resulted in monodisperse nanocrystals with an average size of 4 nm. Mössbauer analysis confirmed that the nanocrystals mainly consisted of maghemite. Analysis of the magnetic hysteresis loop measurements and the zero field and field cooled measurements displayed an excellent fit to established theories for single-domain superparamagnetic nanocrystals and the size of the magnetic domains correlated well to the crystallite size obtained from transmission electron microscope.
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| 4. |
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| 5. |
- Al-Smadi, Derar, 1983-, et al.
(författare)
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Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di-, and Tri-Hydroxypentanones
- 2019
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Ingår i: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 84:11, s. 6982-6991
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Tidskriftsartikel (refereegranskat)abstract
- Polyhydroxylated compounds are building blocks for the synthesis of carbohydrates and other natural products. Their synthesis is mainly achieved by different synthetic versions of aldol-coupling reactions, catalyzed either by organocatalysts, enzymes or metal-organic catalysts. We have investigated the formation of 1,4-substituted 2,3-dihydroxybutan-1-one derivatives from para- and meta-substituted phenylacetaldehydes by three distinctly different strategies. The first involved a direct aldol reaction with hydroxyacetone, dihydroxyacetone or 2-hydroxyacetophenone, catalyzed by the cinchona derivative cinchonine. The second was reductive cross-coupling with methyl or phenyl glyoxal promoted by SmI2 resulting in either 5-substituted 3,4-dihydroxypentan-2-ones or 1,4 bis-phenyl substituted butanones, respectively. Finally, in the third case, aldolase catalysis was employed for synthesis of the corresponding 1,3,4-trihydroxylated pentan-2-one derivatives. The organocatalytic route with cinchonine generated distereomerically enriched syn products (de = 60−99 %), with moderate enantiomeric excesses (ee = 43−56%), but did not produce aldols with either hydroxyacetone or dihydroxyacetone as donor ketones. The SmI2-promoted reductive cross-coupling generated product mixtures with diastereomeric and enantiomeric ratios close to unity. This route allowed for the production of both 1-methyl- and 1-phenylsubstituted 2,3-dihydroxybutanones, at yields between 40−60%. Finally, the biocatalytic approach resulted in enantiopure syn (3R,4S) 1,3,4-trihydroxypentan-2-ones.
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| 6. |
- Ashour, Radwa, et al.
(författare)
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DTPA-Functionalized Silica Nano- and Microparticles for Adsorption and Chromatographic Separation of Rare Earth Elements
- 2018
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Ingår i: ACS Sustainable Chemistry and Engineering. - : American Chemical Society (ACS). - 2168-0485. ; 6:5, s. 6889-6900
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Tidskriftsartikel (refereegranskat)abstract
- Silica nanoparticles and porous microparticles have been successfully functionalized with a monolayer of DTPA-derived ligands. The ligand grafting is chemically robust and does not appreciably influence the morphology or the structure of the material. The produced particles exhibit quick kinetics and high capacity for REE adsorption. The feasibility of using the DTPA-functionalized microparticles for chromatographic separation of rare earth elements has been investigated for different sample concentrations, elution modes, eluent concentrations, eluent flow rates, and column temperatures. Good separation of the La(III), Ce(III), Pr(III), Nd(III), and Dy(III) ions was achieved using HNO3 as eluent using a linear concentration gradient from 0 to 0.15 M over 55 min. The long-term performance of the functionalized column has been verified, with very little deterioration recorded over more than 50 experiments. The results of this study demonstrate the potential for using DTPA-functionalized silica particles in a chromatographic process for separating these valuable elements from waste sources, as an environmentally preferable alternative to standard solvent-intensive processes.
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| 7. |
- Bedin, Michele, PhD, 1984-
(författare)
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Iron, Manganese and Iridium Complexes From Models of RNR and Catalase to Water Oxidation
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The focus of this thesis has been synthesise and study metal complexes that mimic the structure and function of the active site in two particular metalloenzymes, ribonucleotide reductase (RNR) and manganese catalase (MnCAT). These two metalloenzymes both have two transition metals ions in the cofactor: two manganese ions in MnCAT and either two iron, iron-manganese or two manganese ions in RNR.Three different ligands were synthetized to make model complexes for these cofactors. The first ligand, BPMP, can bind two metal ions and provides two symmetric pockets with two pyridine groups and one amine each, plus a phenolate group that can bridge the two metals. The second ligand DPCPMP had one carboxylate group instead of a pyridine group in one pocket, creating an asymmetric ligand, and the third ligand BPCPMP, had two carboxylate groups, one in each pocket. From the first and the second ligands it was possible to obtain six complexes: low-valent homometallic Mn/Mn and Fe/Fe complexes and a heterometallic complex for each ligand. For the third ligand, only the Fe/Fe complex was synthetized.All seven complexes were characterized by a number of spectroscopic methods. The presence of carboxylate groups in the ligand shifted the redox potential for the metal complexes towards more negative values, particularly in the case of the homometallic Fe/Fe complexes. Surprisingly, for the asymmetric ligand the placement of the metal ions in the two pockets was not dictated by the asymmetry. Additionally, the relative stability of the homometallic complexes versus the heterometallic complexes and the possibility to transform a homometallic complex into a heterometallic complex were investigated. By titrating one metal into a solution containing the other homometallic dimer it was possible to observe that Fe2+ added to a solution of a Mn/Mn complex led to the replacement of one Mn ion in the complex with a Fe ion.The manganese complex of DPCPMP was investigated as a functional model for MnCAT, catalysing the disproportionation of H2O2 to oxygen and water. In the presence of H2O2 this complex also forms a high-valent species with a di-µ-oxo bridge similar to the MnCAT and RNR.Finally, the methodology used for the study of these complexes was also applied to a set of Ir complexes that act as water oxidation catalysts, and we could show that the presence of a pendant group stabilizes the metal at higher oxidation states leading to higher activity for the catalyst.
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| 8. |
- Berggren Kleja, Dan, et al.
(författare)
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Bismuth(III) Forms Exceptionally Strong Complexes with Natural Organic Matter
- 2022
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 56, s. 3076-3084
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Tidskriftsartikel (refereegranskat)abstract
- The use of bismuth in the society has steadily increased during the last decades, both as a substitute for lead in hunting ammunition and various metallurgical applications, as well as in a range of consumer products. At the same time, the environmental behavior of bismuth is largely unknown. Here, the binding of bismuth(III) to organic soil material was investigated using extended X-ray absorption spectroscopy (EXAFS) and batch experiments. Moreover, the capacity of suwannee river fulvic acid (SRFA) to enhance the solubility of metallic bismuth was studied in a long-term (2 years) equilibration experiment. Bismuth(III) formed exceptionally strong complexes with the organic soil material, where >99% of the added bismuth(III) was bound by the solid phase, even at pH 1.2. EXAFS data suggest that bismuth(III) was bound to soil organic matter as a dimeric Bi3+ complex where one carboxylate bridges two Bi3+ ions, resulting in a unique structural stability. The strong binding to natural organic matter was verified for SRFA, dissolving 16.5 mmol Bi per gram carbon, which largely exceeds the carboxylic acid group density of this compound. Our study shows that bismuth(III) will most likely be associated with natural organic matter in soils, sediments, and waters.
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| 9. |
- Breijaert, T. C., et al.
(författare)
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Self-assembly of ferria – nanocellulose composite fibres
- 2022
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Ingår i: Carbohydrate Polymers. - : Elsevier Ltd. - 0144-8617 .- 1879-1344. ; 291
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Tidskriftsartikel (refereegranskat)abstract
- An environmentally benign synthesis of a magnetically responsive carboxymethylated cellulose nanofibril-based material is reported. Applied experimental conditions lead to the in-situ formation of magnetite nanoparticles with primary particle sizes of 2.0–4.0 nm or secondary particles of 3.6–16.4 nm depending on whether nucleation occurred between individual carboxymethylated cellulose nanofibrils, or on exposed fibril surfaces. The increase in magnetite particle size on the cellulose fibril surfaces was attributed to Ostwald ripening, while the small particles formed within the carboxymethyl cellulose aggregates were presumably due to steric interactions. The magnetite nanoparticles were capable of coordinating to carboxymethylated cellulose nanofibrils to form large “fibre-like” assemblies. The confinement of small particles within aggregates of reductive cellulose molecules was most likely responsible for excellent conservation of magnetic characteristics on storage of this material. The possibility for using the material in drug delivery applications with release rate controlled by daylight illumination is presented. © 2022 The Author(s)
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| 10. |
- Breijaert, Troy C., et al.
(författare)
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Tailoring a bio-based adsorbent for sequestration of late transition and rare earth elements
- 2022
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Ingår i: Dalton Transactions. - : Royal Society of Chemistry. - 1477-9226 .- 1477-9234. ; 51:47, s. 17978-17986
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Tidskriftsartikel (refereegranskat)abstract
- The demand for new renewable energy sources, improved energy storage and exhaust-free transportation requires the use of large quantities of rare earth (REE) and late transition (LTM, group 8–12) elements. In order to achieve sustainability in their use, an efficient green recycling technology is required. Here, an approach, a synthetic route and an evaluation of the designed bio-based material are reported. Cotton-derived nano cellulose particles were functionalized with a polyamino ligand, tris(2-aminoethyl) amine (TAEA), achieving ligand content of up to ca. 0.8 mmol g−1. The morphology and structure of the produced adsorbent were revealed by PXRD, SEM-EDS, AFM and FTIR techniques. The adsorption capacity and kinetics of REE and LTM were investigated by conductometric photometric titrations, revealing quick uptake, high adsorption capacity and pronounced selectivity for LTM compared to REE. Molecular insights into the mode of action of the adsorbent were obtained via the investigation of the molecular structure of the Ni(II)–TAEA complex by an X-ray single crystal study. The bio-based adsorbent nanomaterial demonstrated in this work opens up a perspective for tailoring specific adsorbents in the sequestration of REE and LTM for their sustainable recycling.
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