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Numrering	Referens	Omslagsbild	Hitta
1.	Ferreira, Mjv, et al. (författare) Poster Session 3 : Tuesday 5 May 2015, 08 2015 Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1 Tidskriftsartikel (refereegranskat)
2.	Kaas, A., et al. (författare) Association between age, IL-10, IFN gamma, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes 2012 Ingår i: Diabetic Medicine. - : Wiley-Blackwell. - 0742-3071 .- 1464-5491. ; 29:6, s. 734-741 Tidskriftsartikel (refereegranskat)abstract AIMS: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes.METHODS: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months.RESULTS: IL-10 decreased (P < 0.001) by 7.7% (1 month), 10.4% (6 months) and 8.6% (12 months) per year increase in age of child, while a twofold higher C-peptide concentration at 1 month (p = 0.06), 6 months (P = 0.0003) and 12 months (P = 0.02) was associated with 9.7%, 18.6% and 9.7% lower IL-10 levels, independent of each other. IL-10 concentrations did not associate with the disease progression groups. By contrast, IFNγ concentrations differed between the four progression groups at 6 and 12 months (P = 0.02 and P = 0.01, respectively); patients with rapid progressing disease had the highest levels at both time points. Distribution of IL-10 and IFNγ genotypes was equal among patients from the progression groups.CONCLUSION: IL-10 serum levels associate inversely with age and C-peptide. As age and C-peptide also associate, a triangular association is proposed. Genetic influence on IL-10 production seems to be masked by distinct disease mechanisms. Increased serum IFNγ concentrations associate with rapid disease progression. Functional genetic variants do not associate with a single progression pattern group, implying that disease processes override genetically predisposed cytokine production.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Hansen, E. (1); Costa, G. (1); Martin, J. (1); Keller, M. (1); Sörensen, Jens (1); Sorensen, J (1); visa fler...; Hassan, A (1); Soares, J (1); Abdelkader, M. (1); Martinez, F. (1); Ramos, D (1); Patel, K (1); Kaas, A. (1); Jukema, J. W. (1); Alizadeh, B. Z. (1); Foley, J (1); Mostafa, S (1); Sayed, S (1); Amin, A. (1); Åman, Jan, 1948- (1); Yoshida, H (1); Bertuccio, G. (1); Buschard, K. (1); Kero, Tanja (1); Saraste, A. (1); Knuuti, J. (1); Cohen, M. (1); Tornos, P (1); Mushtaq, S (1); Bertella, E (1); Baggiano, A (1); Petulla', M (1); Conte, E (1); Andreini, D (1); Pontone, G (1); De Graaf, M A (1); Bax, J J (1); Scholte, A J (1); Thackeray, J T (1); Bengel, F M (1); Harms, H J (1); Tolbod, L P (1); Hansson, N H (1); Kim, W Y (1); Bouchelouche, K (1); Wiggers, H (1); Frokiaer, J (1); Erglis, A (1); Kornowski, R (1); Mintale, I (1); visa färre...

Lärosäte: Uppsala universitet (1); Örebro universitet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

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