| 1. |
- Ademuyiwa, Adesoji O., et al.
(författare)
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Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- 2016
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Ingår i: BMJ Global Health. - : BMJ Publishing Group Ltd. - 2059-7908. ; 1:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally.Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression.Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed.Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas.
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| 2. |
- Nguyen, Thanh N, et al.
(författare)
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Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.
- 2023
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Ingår i: Neurology. - 1526-632X. ; 100:4
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Tidskriftsartikel (refereegranskat)abstract
- Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020).We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases.There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations.There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.This study is registered under NCT04934020.
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| 3. |
- Anjum, Misbah, et al.
(författare)
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A framework for optimal patch release time using G-DEMATEL and multi-attribute utility theory
- 2024
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Ingår i: International Journal of Industrial and Systems Engineering. - : Inderscience Publishers. - 1748-5037 .- 1748-5045. ; 46:4, s. 531-555
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Tidskriftsartikel (refereegranskat)abstract
- The primary focus of the present work is to determine the optimal vulnerability patch release time using multi-attribute utility theory (MAUT) by considering two objectives that are cost minimisation and reliability maximisation. The novelty of the study lies in multi-phased research methodology for identifying the attributes affecting the software patch release time through a combination of literature review and the grey-Delphi approach for guiding the optimisation process. The literature has directly considered the weights of the attributes without emphasising their interrelationships, which is overcome by the use of the DEMATEL methodology under the grey environment in the current study for the evaluation of weights of selected attributes. The implications of the study will help in achieving the sustainable development goals pertaining to innovation and infrastructure. A numerical example is used to demonstrate the relevance of the optimisation problem.
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| 4. |
- Kish, Laszlo B, et al.
(författare)
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Information, Noise, and Energy Dissipation: : Laws, Limits, and Applications
- 2017
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Ingår i: Molecular Architectonics. - Cham : Springer. - 9783319570952 ; , s. 27-44
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Bokkapitel (refereegranskat)abstract
- This chapter addresses various subjects, including some open questions related to energy dissipation, information, and noise, that are relevant for nano- and molecular electronics. The object is to give a brief and coherent presentation of the results of a number of recent studies of ours
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| 5. |
- Kish, Laszlo Bela, et al.
(författare)
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Response to "Comment on 'Zero and negative energy dissipation at information-theoretic erasure'"
- 2016
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Ingår i: Journal of Computational Electronics. - : Springer Science and Business Media LLC. - 1569-8025 .- 1572-8137. ; 15:1, s. 343-346
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Tidskriftsartikel (refereegranskat)abstract
- We prove that statistical information-theoretic quantities, such as information entropy, cannot generally be interrelated with the lower limit of energy dissipation during information erasure. We also point out that, in deterministic and error-free computers, the information entropy of memories does not change during erasure because its value is always zero. On the other hand, for information-theoretic erasure-i.e., "thermalization"/randomization of the memory-the originally zero information entropy (with deterministic data in the memory) changes after erasure to its maximum value, 1 bit/memory bit, while the energy dissipation is still positive, even at parameters for which the thermodynamic entropy within the memory cell does not change. Information entropy does not convert to thermodynamic entropy and to the related energy dissipation; they are quantities of different physical nature. Possible specific observations (if any) indicating convertibility are at most fortuitous and due to the disregard of additional processes that are present.
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| 6. |
- Kish, Laszlo Bela, et al.
(författare)
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Zero and negative energy dissipation at information-theoretic erasure
- 2016
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Ingår i: Journal of Computational Electronics. - : Springer Science and Business Media LLC. - 1569-8025 .- 1572-8137. ; 15:1, s. 335-339
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Tidskriftsartikel (refereegranskat)abstract
- We introduce information-theoretic erasure based on Shannon's binary channel formula. It is pointed out that this type of erasure is a natural energy-dissipation-free way in which information is lost in double-potential-well memories, and it may be the reason why the brain can forget things effortlessly. We also demonstrate a new non-volatile, charge-based memory scheme wherein the erasure can be associated with even negative energy dissipation; this implies that the memory's environment is cooled during information erasure and contradicts Landauer's principle of erasure dissipation. On the other hand, writing new information into the memory always requires positive energy dissipation in our schemes. Finally, we show a simple system where even a classical erasure process yields negative energy dissipation of arbitrarily large energy.
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| 7. |
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