| 1. |
- Aminoroaya, Alireza, et al.
(författare)
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A Review of Dental Composites : Methods Of Characterizations
- 2020
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Ingår i: ACS Biomaterials Science & Engineering. - : American Chemical Society (ACS). - 2373-9878. ; 6:7, s. 3713-3744
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Forskningsöversikt (refereegranskat)abstract
- Dental composites are becoming increasingly popular in esthetic restorative dentistry and present a promising substitute for amalgam. However, the major hurdles that hinder their total adoption in restorative dentistry are limited longevity and possible health risks, leading to significant attempts for addressing these shortcomings. Besides the new materials, the evaluation methods play a critical role in the introduction and improvement of these types of materials. This review aims to cover the characterization methods in the evaluation of dental composites that are most employed nowadays. Therefore, the methods for evaluating the physical properties of the dental composites are first explained. Subsequently, the assessment methods of curing kinetics and the mechanical properties of the composites are classified and reviewed. Afterward, the article delves into the introduction and classification of the microscopic and antibacterial evaluation methods. Finally, the test methods for assessment of in vitro cytotoxicity and self-healing ability are described. It should be noted, for each test method, the most recent and interesting articles are cited. It is envisaged that this review will facilitate an understanding and provide knowledge for the section and utilizing the most effective and suitable characterization methods for future research on the development of dental composites.
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| 2. |
- Aminoroaya, Alireza, et al.
(författare)
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A review of dental composites : Challenges, chemistry aspects, filler influences, and future insights
- 2021
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Ingår i: Composites Part B. - : Elsevier. - 1359-8368 .- 1879-1069. ; 216
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Forskningsöversikt (refereegranskat)abstract
- Resin-based dental composites are promising tooth-resembling materials in restorative dentistry. The limited longevity of dental composite restorations due to the bulk/marginal fracture and secondary caries as well as possible health risks are the critical challenges faced by such materials. Therefore, developments of resin-based dental composites received considerable attention in academic researches for clinical applications. A comprehensive review of the recent developments in the scientific literature on resin-based dental composites is presented in this article. Firstly, in the article, the challenges in dental composites are introduced and then the chemical aspects of the systems are classified through a review of employed resins. Subsequently, the different characteristics related to the fillers employed for the development of the resin-based dental composites are described. Finally, conclusions are drawn and future insights are proposed. This article provides an insight that paves the way for tailoring and designing resin-based dental composites for clinical applications.
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| 3. |
- Aminoroaya, Alireza, et al.
(författare)
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Facile encapsulation of cyanoacrylate-based bioadhesive by electrospray method and investigation of the process parameters
- 2024
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Ingår i: Scientific Reports. - : Nature Research. - 2045-2322. ; 14:1
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Tidskriftsartikel (refereegranskat)abstract
- Polymer microcapsules containing cyanoacrylates have represented a promising option to develop self-healing biomaterials. This study aims to develop an electrospray method for the preparation of capsules using poly(methyl methacrylate) (PMMA) as the encapsulant and ethyl 2-cyanoacrylate (EC) as the encapsulate. It also aims to study the effect of the electrospray process parameters on the size and morphology of the capsules. The capsules were characterized using Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and field-emission scanning electron microscopy (FE-SEM). Moreover, the effects of electrospray process parameters on the size were investigated by Taguchi experimental design. FTIR and TGA approved the presence of both PMMA and EC without further reaction. FE-SEM micrograph demonstrated that an appropriate choice of solvents, utilizing an appropriate PMMA:EC ratio and sufficient PMMA concentration are critical factors to produce capsules dominantly with an intact and spherical morphology. Utilizing various flow rates (0.3–0.5 ml/h) and applied voltage (18–26 kV), capsules were obtained with a 600–1000 nm size range. At constantly applied voltages, the increase in flow rate increased the capsule size up to 40% (ANOVA, p ≤ 0.05), while at constant flow rates, the increase in applied voltage reduced the average capsule size by 3.4–26% (ANOVA, p ≤ 0.05). The results from the Taguchi design represented the significance of solution flow rate, applied voltage, and solution concentration. It was shown that the most effective parameter on the size of capsules is flow rate. This research demonstrated that electrospray can be utilized as a convenient method for the preparation of sub-micron PMMA capsules containing EC. Furthermore, the morphology of the capsules is dominated by solvents, PMMA concentration, and PMMA:EC ratio, while the average size of the capsules can be altered by adjusting the flow rate and applied voltage of the electrospray process.
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| 4. |
- Ghane, Nazanin, et al.
(författare)
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Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery
- 2024
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 14
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Tidskriftsartikel (refereegranskat)abstract
- The current study developed an innovative design for the production of smart multifunctional core-double shell superparamagnetic nanoparticles (NPs) with a focus on the development of a pH-responsive drug delivery system tailored for the controlled release of Phenytoin, accompanied by real-time monitoring capabilities. In this regard, the ultra-small superparamagnetic iron oxide@silica NPs (IO@Si MNPs) were synthesized and then coated with a layer of gelatin containing Phenytoin as an antiepileptic drug. The precise saturation magnetization value for the resultant NPs was established at 26 emu g-1. The polymeric shell showed a pH-sensitive behavior with the capacity to regulate the release of encapsulated drug under neutral pH conditions, simultaneously, releasing more amount of the drug in a simulated tumorous-epileptic acidic condition. The NPs showed an average size of 41.04 nm, which is in the desired size range facilitating entry through the blood–brain barrier. The values of drug loading and encapsulation efficiency were determined to be 2.01 and 10.05%, respectively. Moreover, kinetic studies revealed a Fickian diffusion process of Phenytoin release, and diffusional exponent values based on the Korsmeyer-Peppas equation were achieved at pH 7.4 and pH 6.3. The synthesized NPs did not show any cytotoxicity. Consequently, this new design offers a faster release of PHT at the site of a tumor in response to a change in pH, which is essential to prevent epileptic attacks.
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| 5. |
- Ghane, Nazanin, et al.
(författare)
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Regeneration of the peripheral nerve via multifunctional electrospun scaffolds
- 2021
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Ingår i: Journal of Biomedical Materials Research. Part A. - : John Wiley & Sons. - 1549-3296 .- 1552-4965. ; 109:4, s. 437-452
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Forskningsöversikt (refereegranskat)abstract
- Over the last two decades, electrospun scaffolds have proved to be advantageous in the field of nerve tissue regeneration by connecting the cavity among the proximal and distal nerve stumps growth cones and leading to functional recovery after injury. Multifunctional nanofibrous structure of these scaffolds provides enormous potential by combining the advantages of nano‐scale topography, and biological science. In these structures, selecting the appropriate materials, designing an optimized structure, modifying the surface to enhance biological functions and neurotrophic factors loading, and native cell‐like stem cells should be considered as the essential factors. In this systematic review paper, the fabrication methods for the preparation of aligned nanofibrous scaffolds in yarn or conduit architecture are reviewed. Subsequently, the utilized polymeric materials, including natural, synthetic and blend are presented. Finally, their surface modification techniques, as well as, the recent advances and outcomes of the scaffolds, both in vitro and in vivo, are reviewed and discussed.
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| 6. |
- Ghomi, Erfan Rezvani, et al.
(författare)
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Synthesis of TiO2 nanogel composite for highly efficient self-healing epoxy coating
- 2023
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Ingår i: Journal of Advanced Research. - : Elsevier. - 2090-1232 .- 2090-1224. ; 43, s. 137-146
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionOrganic coatings are the most effective and facile methods of protecting steel against corrosion, which shields it from direct contact with oxygen and moisture. However, they are inherently defective and susceptible to damage, which allows the penetration of the corrosive media into the underlying substrates. Self-healing coatings were developed to address this shortcoming.ObjectiveThe current research aims to develop a coating with superior self-healing ability via embedment of titanium dioxide (TiO2) nanogel composite (NC) in a commercial epoxy.MethodsThe TiO2 NC was prepared by efficient dispersion of TiO2 nanoparticles in copolymer gel of acrylamide (AAm) and 2-acrylamido-2-methyl propane sulfonic acid (AMPS) with the help of 3-(trimethoxysilyl) propyl methacrylate (MPS). The chemical structure, morphology, and thermal properties of the modified and functionalized nanoparticles were assessed by infrared spectroscopy, electron microscopy, X-ray diffraction, and thermogravimetric analysis, respectively. In addition, TiO2 nanoparticles, nano-TiO2 functionalized monomer (NTFM), and NTFM/AAm/AMPS in different weight percentages were incorporated into epoxy resin to prepare a self-healing coating.ResultsThe results confirmed the successful fabrication of the NC. In addition, the incorporation of 1 wt% NTFM/AAm/AMPS led to homogenous dispersion, enhanced anti-corrosive and self-healing performance with the healing efficiencies of 100% and 98%, which were determined by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization methods, respectively.ConclusionThe prepared NC was sensitive towards salt concentration, pH, which aids the quick reaction of the TiO2 NC to corrosive ions, once the cracks occur. In addition, this is a unique feature compared to the other self-healing mechanisms, especially, the encapsulation of healing agents, which can be effective as long as the healing agent is present.
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| 7. |
- Ghomi, Erfan Rezvani, et al.
(författare)
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Wound dressings : Current advances and future directions
- 2019
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Ingår i: Journal of Applied Polymer Science. - Hoboken : John Wiley & Sons. - 0021-8995 .- 1097-4628. ; 136:27
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Tidskriftsartikel (refereegranskat)abstract
- Wound healing is a complicated and continuous process affected by several factors, which needs an appropriate surroundingto achieve accelerated healing. Wound healing process recruits three different phases: inflammation, proliferation, and maturation. Dueto the different types of wounds, as well as the advancement in medical technology, various products have been developed to repair dif-ferent skin lesions. Our objective is to investigate the advancement in wound dressings from traditional to the current methods of treat-ment. The article presents the characteristics of an ideal wound dressing, the requirements for the appropriate selection of differenttypes of wounds, and a detailed classification of wound dressings. Animal origin, herbal origin, and synthetic dressings arefirstly intro-duced and reviewed. Then, nonmedicated dressings including alginate, hydrogel, and hydrocolloid dressings, as well as medicated dress-ings are discussed. Finally, the developmental prospectives of the new generations of wound dressings for future researches arepresented.
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| 8. |
- Khosravi, Fatemeh, et al.
(författare)
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A bilayer GO/nanofibrous biocomposite coating to enhance 316L stainless steel corrosion performance
- 2019
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Ingår i: Materials Research Express. - : Institute of Physics (IOP). - 2053-1591. ; 6:8
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Tidskriftsartikel (refereegranskat)abstract
- A bilayer coating has been synthesized to be coated on the 316L stainless steel (SS) for bone implant application. The first layer consisted of graphene oxide (GO) which was coated via the electrophoretic deposition method. The second layer including Poly (ε-caprolactone) (PCL)/Gelatin-forsterite nanofibers was electrospun on the first layer. The morphology of the bare 316L SS, GO-coated, electrospun nanofibers, and nanofibers-coated samples were investigated using scanning electron microscopy (SEM). The electrospun nanofibers were also characterized by Fourier transform infrared spectroscopy (FTIR) and confirmed the presence of PCL, gelatin, and forsterite in the nanocomposite coating. Furthermore, the morphological investigation of the nanofibers revealed that 80:20 weight of PCL to gelatin did not show any beads, making them for coating on the GO coatings. In addition, the corrosion behavior of the coated samples was assessed by potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). The samples coated with GO and GO/PCL-gelatin-forsterite 1% showed the best corrosion resistance in comparison with other samples. Consequently, the prepared bilayer biocomposite coating including 1 wt% forsterite nanoparticles can be a promising candidate for orthopedic implants.
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| 9. |
- Khosravi, Fatemeh, et al.
(författare)
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Development of a Highly Proliferated Bilayer Coating on 316L Stainless Steel Implants
- 2020
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Ingår i: Polymers. - : MDPI. - 2073-4360. ; 12:5
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Tidskriftsartikel (refereegranskat)abstract
- In this research, a bilayer coating has been applied on the surface of 316 L stainless steel (316LSS) to provide highly proliferated metallic implants for bone regeneration. The first layer was prepared using electrophoretic deposition of graphene oxide (GO), while the top layer was coated utilizing electrospinning of poly (ε-caprolactone) (PCL)/gelatin (Ge)/forsterite solutions. The morphology, porosity, wettability, biodegradability, bioactivity, cell attachment and cell viability of the prepared coatings were evaluated. The Field Emission Scanning Electron Microscopy (FESEM) results revealed the formation of uniform, continuous, and bead-free nanofibers. The Energy Dispersive X-ray (EDS) results confirmed well-distributed forsterite nanoparticles in the structure of the top coating. The porosity of the electrospun nanofibers was found to be above 70%. The water contact angle measurements indicated an improvement in the wettability of the coating by increasing the amount of nanoparticles. Furthermore, the electrospun nanofibers containing 1 and 3 wt.% of forsterite nanoparticles showed significant bioactivity after soaking in the simulated body fluid (SBF) solution for 21 days. In addition, to investigate the in vitro analysis, the MG-63 cells were cultured on the PCL/Ge/forsterite and GO-PCL/Ge/forsterite coatings. The results confirmed an excellent cell adhesion along with considerable cell growth and proliferation. It should be also noted that the existence of the forsterite nanoparticles and the GO layer substantially enhanced the cell proliferation of the coatings.
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| 10. |
- Koochaki, Mohammad Sadegh, et al.
(författare)
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Facile strategy toward the development of a self-healing coating by electrospray method
- 2019
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Ingår i: Materials Research Express. - : Institute of Physics (IOP). - 2053-1591. ; 6:11
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Tidskriftsartikel (refereegranskat)abstract
- A self-healing anti-corrosion epoxy coating was prepared by the incorporation of dual capsule healing system. Microcapsules were prepared through the facile electrospray method by using Poly(styrene-co-acrylonitrile) polymer as shell material. Polyetheramine and Methylene diphenyl diisocyanate (MDI) based isocyanate prepolymer were utilized as core materials because of their high reactivity and low sensitivity in forming polyurea polymers. Scanning electron microscopy (sem) images confirmed the spherical morphology of the prepared microcapsules with average diameters of 0.93 ± 0.55 μm and 1.21 ± 0.68 μm for the encapsulated polyetheramine and isocyanate microcapsules, respectively. Moreover, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA) results confirmed the successful encapsulation of both core materials with a high encapsulation yield (71% and 68% for Polyetheramine and MDI based isocyanate respectively). Electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization technique were used to assess the effects of utilizing the aforementioned system on the intrinsic anti-corrosion barrier property (on pristine samples ) and the self-healing efficiency (after cross scratching) of the resulting smart coatings. The corrosion assessment results confirmed the self-healing performance of the incorporated capsules along with a high healing efficiency (85%) for the optimum microcapsule content.
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