SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Khoury S) "

Sökning: WFRF:(Khoury S)

  • Resultat 1-10 av 68
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • 2021
  • swepub:Mat__t
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  • Khoury, J. D., et al. (författare)
  • The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms
  • 2022
  • Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 36, s. 1703-1719
  • Tidskriftsartikel (refereegranskat)abstract
    • The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.
  •  
10.
  • Macari, F., et al. (författare)
  • TRM6/61 connects PKCα with translational control through tRNAiMet stabilization : impact on tumorigenesis
  • 2016
  • Ingår i: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 35:14, s. 1785-1796
  • Tidskriftsartikel (refereegranskat)abstract
    • Accumulating evidence suggests that changes of the protein synthesis machinery alter translation of specific mRNAs and participate in malignant transformation. Here we show that protein kinase C [alpha] (PKC[alpha]) interacts with TRM61, the catalytic subunit of the TRM6/61 tRNA methyltransferase. The TRM6/61 complex is known to methylate the adenosine 58 of the initiator methionine tRNA (tRNAiMet), a nuclear post-transcriptional modification associated with the stabilization of this crucial component of the translation-initiation process. Depletion of TRM6/61 reduced proliferation and increased death of C6 glioma cells, effects that can be partially rescued by overexpression of tRNAiMet. In contrast, elevated TRM6/61 expression regulated the translation of a subset of mRNAs encoding proteins involved in the tumorigenic process and increased the ability of C6 cells to form colonies in soft agar or spheres when grown in suspension. In TRM6/61/tRNAiMet-overexpressing cells, PKC[alpha] overexpression decreased tRNAiMet expression and both colony- and sphere-forming potentials. A concomitant increase in TRM6/TRM61 mRNA and tRNAiMet expression with decreased expression of PKC[alpha] mRNA was detected in highly aggressive glioblastoma multiforme as compared with Grade II/III glioblastomas, highlighting the clinical relevance of our findings. Altogether, we suggest that PKC[alpha] tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 68
Typ av publikation
tidskriftsartikel (59)
konferensbidrag (5)
bokkapitel (2)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (55)
övrigt vetenskapligt/konstnärligt (12)
Författare/redaktör
Khoury, S. (14)
Weiss, DJ (5)
El Khoury, A (5)
Mathe, AA (4)
Ho, D (3)
Mehta, A. (2)
visa fler...
Robson, A. (2)
Wu, M. (2)
Zhang, H. (2)
Brown, G. (2)
Banerjee, S. (2)
Thomas, P. (2)
Kumar, A. (2)
Gupta, R. (2)
Thomas, D. (2)
KLARESKOG, L (2)
Brown, R. (2)
Clark, J. (2)
Yamamoto, R. (2)
Khan, M (2)
Ranta, A (2)
Singh, A (2)
Smith, A (2)
Truelsen, TC (2)
Venketasubramanian, ... (2)
Yamada, T (2)
Wareham, Nick (2)
Riboli, Elio (2)
Farhoudi, M (2)
Yu, S. (2)
Shah, R. (2)
Berti, E. (2)
Hillert, J (2)
Spelman, T (2)
Lee, J. (2)
Piehl, F (2)
Wigerblad, G (2)
Svensson, CI (2)
Gronwall, C. (2)
Sonoda, K (2)
Pellegrini, F (2)
Fischer, U (2)
Mathe, A (2)
Wang, W. (2)
Smith, L (2)
Williams, D. (2)
Malmstrom, V (2)
Vanacker, P. (2)
Tsivgoulis, G. (2)
Sharma, K (2)
visa färre...
Lärosäte
Karolinska Institutet (48)
Uppsala universitet (8)
Lunds universitet (7)
Göteborgs universitet (6)
Umeå universitet (4)
Linköpings universitet (3)
visa fler...
Stockholms universitet (2)
Kungliga Tekniska Högskolan (1)
Mälardalens universitet (1)
Örebro universitet (1)
Linnéuniversitetet (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (68)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (21)
Naturvetenskap (5)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy