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| 2. |
- Kim, Joon Tae, et al.
(författare)
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Dual antiplatelet Use for extended period taRgeted to AcuTe ischemic stroke with presumed atherosclerotic OrigiN (DURATION) trial : Rationale and design
- 2023
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Ingår i: International Journal of Stroke. - : SAGE Publications. - 1747-4930 .- 1747-4949. ; 18:8, s. 1015-1020
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Tidskriftsartikel (refereegranskat)abstract
- Rationale: The optimal duration of dual antiplatelet therapy (DAPT) with clopidogrel-aspirin for the large artery atherosclerotic (LAA) stroke subtype has been debated. Aims: To determine whether the 1-year risk of recurrent vascular events could be reduced by a longer duration of DAPT in patients with the LAA stroke subtype. Methods and study design: A total of 4806 participants will be recruited to detect a statistically significant relative risk reduction of 22% with 80% power and a two-sided alpha error of 0.05, including a 10% loss to follow-up. This is a registry-based, multicenter, prospective, randomized, open-label, blinded end point study designed to evaluate the efficacy and safety of a 12-month duration of DAPT compared with a 3-month duration of DAPT in the LAA stroke subtype. Patients will be randomized (1:1) to either DAPT for 12 months or DAPT for 3 months, followed by monotherapy (either aspirin or clopidogrel) for the remaining 9 months. Study outcomes: The primary efficacy outcome of the study is a composite of stroke (ischemic or hemorrhagic), myocardial infarction, and all-cause mortality for 1 year after the index stroke. The secondary efficacy outcomes are (1) stroke, (2) ischemic stroke or transient ischemic attack, (3) hemorrhagic stroke, and (4) all-cause mortality. The primary safety outcome is major bleeding. Discussion: This study will help stroke physicians determine the appropriate duration of dual therapy with clopidogrel-aspirin for patients with the LAA stroke subtype. Trial registration: URL: https://cris.nih.go.kr/cris. CRIS Registration Number: KCT0004407.
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| 3. |
- Jung, Young-Eun, et al.
(författare)
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The Korean version of the Connor-Davidson Resilience Scale: An extended validation
- 2012
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Ingår i: Stress and Health. - : John Wiley & Sons. - 1532-3005 .- 1532-2998. ; 28:4, s. 319-326
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Tidskriftsartikel (refereegranskat)abstract
- The Connor–Davidson Resilience Scale (CD‐RISC) is a brief self‐rating questionnaire for measuring resilience. The aims of the present study were to describe the development of a Korean version of the CD‐RISC (K‐CD‐RISC) and to more firmly establish its psychometric properties in terms of reliability and validity. The participants consisted of a general population sample (n = 194) and psychiatric outpatients (n = 127) with non‐psychotic mood or anxiety disorders. The K‐CD‐RISC score means (standard deviation) were 65.9 (13.6) in the general population and 50.4 (20.5) in the psychiatric outpatients. The mean score of the general population was significantly higher than that of the psychiatric outpatients. Exploratory factor analysis revealed five factors, and the obtained factor structure was verified through confirmatory factor analysis. In the general population, the Cronbach's α coefficient of the K‐CD‐RISC was found to be 0.92. Greater resilience was found to be associated with less perceived stress, anxiety and depression and with higher levels of positive affect and purpose in life. Taken together, our findings suggest that the K‐CD‐RISC has good psychometric properties and is a valid and reliable tool for assessing resilience.
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| 4. |
- Kim, Tae Kyung, et al.
(författare)
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Fabrication of Microfluidic Platform with Optimized Fluidic Network toward On-Chip Parallel Systematic Evolution of Ligands by Exponential Enrichment Process
- 2011
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Ingår i: Japanese Journal of Applied Physics. - 0021-4922. ; 50:6, s. 05-06
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the design and fabrication of a microplatform with the optimal fluidic network for an on-chip parallel "systematic evolution of ligands by exponential enrichment" (SELEX) process. The effectiveness of the optimized fluidic network for on-chip five-plex aptamer screening was verified by measuring the airflow rate at the elution ports and visualizing the specific elution during the SELEX process. The proposed device with an optimally designed hydraulic resistance-balanced channel network could be feasible and utilized as a multiplex selection module for a parallel SELEX process. (c) 2011 The Japan Society of Applied Physics
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| 5. |
- Hwang, Sunbin, et al.
(författare)
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All-Solid-State Organic Schmitt Trigger Implemented by Twin Two-in-One Ferroelectric Memory Transistors
- 2020
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Ingår i: Advanced Electronic Materials. - : WILEY. - 2199-160X. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- Although there have been many attempts to replace conventional inorganic electronics with organic materials that can be mass produced at low cost, few organic electronic filters to increase immunity to electrical noise have been reported thus far. Conventional Schmitt triggers or their inverters are used in many electronic circuits as versatile electronic noise filters. However, it is challenging to manufacture organic electronic systems with complex circuitry. In this study, a simple, all-solid-state organic Schmitt trigger consisting of twin two-in-one organic ferroelectric memory transistors with the same chemical compositions and device dimensions but different threshold voltages is introduced. Threshold voltages and hysteresis in the two-in-one devices can be controlled by polarization switching as demonstrated in a previous study. Hysteresis of a ferroelectric p-type depletion load inverter can be achieved using twin two-in-one devices when the sweep voltage is higher than the critical gate voltages. This facilitates inverter characteristics at two different threshold voltages, and realizing a Schmitt trigger. Finally, based on simulation program with integrated circuit emphasis (SPICE) simulation, guidelines are proposed on how to design organic Schmitt triggers with p- or n-type materials and ferroelectric or charge-trapping mechanisms to achieve inverting or non-inverting characteristics.
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| 6. |
- Hwang, Sunbin, et al.
(författare)
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Two-in-One Device with Versatile Compatible Electrical Switching or Data Storage Functions Controlled by the Ferroelectricity of P(VDF-TrFE) via Photocrosslinking
- 2019
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Ingår i: ACS Applied Materials and Interfaces. - : AMER CHEMICAL SOC. - 1944-8244 .- 1944-8252. ; 11:28, s. 25358-25368
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Tidskriftsartikel (refereegranskat)abstract
- Organic electronics demand new platforms that can make integrated circuits and undergo mass production while maintaining diverse functions with high performance. The field-effect transistor has great potential to be a multifunctional device capable of sensing, data processing, data storage, and display. Currently, transistor-based devices cannot be considered intrinsic multifunctional devices because all installed functions are mutually coupled. Such incompatibilities are a crucial barrier to developing an all-in-one multifunctional device capable of driving each function individually. In this study, we focus on the decoupling of electric switching and data storage functions in an organic ferroelectric memory transistor. To overcome the incompatibility of each function, the high permittivity needed for electrical switching and the ferroelectricity needed for data storage become compatible by restricting the motion of poly(vinylidene fluoride-trifluoroethylene) via photocrosslinking with bis-perfluorobenzoazide. The two-in-one device consisting of a photocrosslinked ferroelectric layer exhibits reversible and individual dual-functional operation as a typical transistor with nonvolatile memory. Moreover, a p-MOS depletion load inverter composed of the two transistors with different threshold voltages is also demonstrated by simply changing only one of the threshold voltages by polarization switching. We believe that the two-in-one device will be considered a potential component of integrated organic logic circuits, including memory, in the future.
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| 7. |
- Kang, Minji, et al.
(författare)
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Light-sensitive charge storage medium with spironaphthooxazine molecule-polymer blends for dual-functional organic phototransistor memory
- 2020
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Ingår i: Organic electronics. - : ELSEVIER. - 1566-1199 .- 1878-5530. ; 78
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Tidskriftsartikel (refereegranskat)abstract
- Organic phototransistor memory is considered as a promising optoelectronic device owing to its multifunctionality. However, due to the poor reliability of each function and the complexity of the device structure, it is necessary to optimize the thin-film process of functional materials when constructing multiple functions into a single device. Here, we demonstrate a dual-functional device that is both a working memory transistor and a phototransistor by incorporating photochromic spironaphthooxazine molecules into an organic insulating layer. The photochmmic molecules in the polymer matrix not only exhibit nonvolatile charge storage properties similar to nano-floating gates but also feature a reversible electronic band structure upon alternating irradiation with ultraviolet and visible light, which makes the device function as both an electrical memory transistor and a phototransistor. Furthermore, the photoresponsive charge trap layer in the demonstrated device leads to excellent memory performance under both dark and light conditions, which includes a large memory window (-56 V), stable endurance cycles (amp;gt;10(2)), and good retention characteristics (amp;gt;10(4) s). Our findings suggest an alternative strategy to realize organic multifunctional nonvolatile memories.
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| 8. |
- Pasquini, Luca, et al.
(författare)
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Magnesium- and intermetallic alloys-based hydrides for energy storage : modelling, synthesis and properties
- 2022
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Ingår i: Progress in Energy. - : Institute of Physics Publishing (IOPP). - 2516-1083. ; 4:3
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Forskningsöversikt (refereegranskat)abstract
- Hydrides based on magnesium and intermetallic compounds provide a viable solution to the challenge of energy storage from renewable sources, thanks to their ability to absorb and desorb hydrogen in a reversible way with a proper tuning of pressure and temperature conditions. Therefore, they are expected to play an important role in the clean energy transition and in the deployment of hydrogen as an efficient energy vector. This review, by experts of Task 40 'Energy Storage and Conversion based on Hydrogen' of the Hydrogen Technology Collaboration Programme of the International Energy Agency, reports on the latest activities of the working group 'Magnesium- and Intermetallic alloys-based Hydrides for Energy Storage'. The following topics are covered by the review: multiscale modelling of hydrides and hydrogen sorption mechanisms; synthesis and processing techniques; catalysts for hydrogen sorption in Mg; Mg-based nanostructures and new compounds; hydrides based on intermetallic TiFe alloys, high entropy alloys, Laves phases, and Pd-containing alloys. Finally, an outlook is presented on current worldwide investments and future research directions for hydrogen-based energy storage.
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