| 1. |
- Gál, Erika, et al.
(författare)
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A fifth- to sixth-century CE lynx (Lynx lynx L., 1758) skeleton from Hungary 2 : Stature and archaeological interpretations
- 2024
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Ingår i: International journal of osteoarchaeology. - 1047-482X .- 1099-1212. ; 34:2
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Tidskriftsartikel (refereegranskat)abstract
- Lynx remains are rare in archaeological assemblages. The skeleton of an adult male accompanied by four dogs was found in a large Migration Period pit at Zamárdi–Kútvölgyi-dűlő II, Hungary. Extant lynx skeletons were used in estimating the shoulder height of this individual. Its stature is comparable to those of the large dogs it was buried with. None of the five skeletons showed skinning marks. Although the physical reconstruction of the lynx was of help in appraising this special pit, the actual nature of the deposit remains in question. Possible interpretations range from the mundane discard of carcasses to the poorly understood ritual burial of carnivores, beginning with the lynx. We reviewed these options within the framework of cultural diversity of Migration Period peoples in west-central Hungary.
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| 2. |
- Gál, Erika, et al.
(författare)
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A fifth–sixth century CE lynx (Lynx lynx L., 1758) skeleton from Hungary : Cranial morphology and zoological interpretations
- 2022
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Ingår i: International journal of osteoarchaeology. - : Wiley. - 1047-482X .- 1099-1212. ; 32:4, s. 783-791
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Tidskriftsartikel (refereegranskat)abstract
- The articulated skeleton of an adult male lynx was found in association with four dogs and scattered bones of other domesticates in a pit at Zamárdi-Kútvölgyi-dűlő II, Hungary. Lynx remains occur rarely in the archaeological record, and protocols for ageing and sexing do not exist. The intact skull of the skeleton offered an opportunity to review the craniological features of the species in comparison with a reference material of extant individuals, complementing our knowledge of lynx osteology, providing an empirical basis for zooarchaeological evaluation. Although caution is due in assigning a concrete function to the curious Zamárdi deposit, familiarity with the craniological properties, habitat preferences, and behavior of Eurasian lynx is indispensable in cultural interpretations subject to a forthcoming study on the osteoarchaeology of this rare wild felid.
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| 3. |
- Patterson, Nick, et al.
(författare)
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Large-scale migration into Britain during the Middle to Late Bronze Age
- 2022
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; , s. 588-594
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Tidskriftsartikel (refereegranskat)abstract
- Present-day people from England and Wales harbour more ancestry derived from Early European Farmers (EEF) than people of the Early Bronze Age1. To understand this, we generated genome-wide data from 793 individuals, increasing data from the Middle to Late Bronze and Iron Age in Britain by 12-fold, and Western and Central Europe by 3.5-fold. Between 1000 and 875 BC, EEF ancestry increased in southern Britain (England and Wales) but not northern Britain (Scotland) due to incorporation of migrants who arrived at this time and over previous centuries, and who were genetically most similar to ancient individuals from France. These migrants contributed about half the ancestry of Iron Age people of England and Wales, thereby creating a plausible vector for the spread of early Celtic languages into Britain. These patterns are part of a broader trend of EEF ancestry becoming more similar across central and western Europe in the Middle to Late Bronze Age, coincident with archaeological evidence of intensified cultural exchange2-6. There was comparatively less gene flow from continental Europe during the Iron Age, and Britain's independent genetic trajectory is also reflected in the rise of the allele conferring lactase persistence to ~50% by this time compared to ~7% in central Europe where it rose rapidly in frequency only a millennium later. This suggests that dairy products were used in qualitatively different ways in Britain and in central Europe over this period.
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| 4. |
- Szeitz, Beáta, et al.
(författare)
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In-depth proteomic analysis reveals unique subtype-specific signatures in human small-cell lung cancer
- 2022
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Ingår i: Clinical and Translational Medicine. - : Wiley. - 2001-1326. ; 12:9, s. 1060-1060
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Small-cell lung cancer (SCLC) molecular subtypes have been primarily characterized based on the expression pattern of the following key transcription regulators: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P) and YAP1 (SCLC-Y). Here, we investigated the proteomic landscape of these molecular subsets with the aim to identify novel subtype-specific proteins of diagnostic and therapeutic relevance.METHODS: Pellets and cell media of 26 human SCLC cell lines were subjected to label-free shotgun proteomics for large-scale protein identification and quantitation, followed by in-depth bioinformatic analyses. Proteomic data were correlated with the cell lines' phenotypic characteristics and with public transcriptomic data of SCLC cell lines and tissues.RESULTS: Our quantitative proteomic data highlighted that four molecular subtypes are clearly distinguishable at the protein level. The cell lines exhibited diverse neuroendocrine and epithelial-mesenchymal characteristics that varied by subtype. A total of 367 proteins were identified in the cell pellet and 34 in the culture media that showed significant up- or downregulation in one subtype, including known druggable proteins and potential blood-based markers. Pathway enrichment analysis and parallel investigation of transcriptomics from SCLC cell lines outlined unique signatures for each subtype, such as upregulated oxidative phosphorylation in SCLC-A, DNA replication in SCLC-N, neurotrophin signalling in SCLC-P and epithelial-mesenchymal transition in SCLC-Y. Importantly, we identified the YAP1-driven subtype as the most distinct SCLC subgroup. Using sparse partial least squares discriminant analysis, we identified proteins that clearly distinguish four SCLC subtypes based on their expression pattern, including potential diagnostic markers for SCLC-Y (e.g. GPX8, PKD2 and UFO).CONCLUSIONS: We report for the first time, the protein expression differences among SCLC subtypes. By shedding light on potential subtype-specific therapeutic vulnerabilities and diagnostic biomarkers, our results may contribute to a better understanding of SCLC biology and the development of novel therapies.
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