| 1. |
- Holmes, Michael V., et al.
(författare)
-
Mendelian randomization of blood lipids for coronary heart disease
- 2015
-
Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 36:9, s. 539-539
-
Tidskriftsartikel (refereegranskat)abstract
- Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian randomization. Methods and results We developed weighted allele scores based on single nucleotide polymorphisms (SNPs) with established associations with HDL-C, triglycerides, and low-density lipoprotein cholesterol (LDL-C). For each trait, we constructed two scores. The first was unrestricted, including all independent SNPs associated with the lipid trait identified from a priormeta-analysis (threshold P < 2 x 10(-6)); and the second a restricted score, filtered to remove any SNPs also associated with either of the other two lipid traits at P <= 0.01. Mendelian randomization meta-analyses were conducted in 17 studies including 62,199 participants and 12,099 CHD events. Both the unrestricted and restricted allele scores for LDL-C (42 and 19 SNPs, respectively) associated with CHD. For HDL-C, the unrestrictedallele score (48SNPs) was associated with CHD(OR: 0.53; 95% CI: 0.40, 0.70), per 1 mmol/L higher HDL-C, but neither the restricted allele score (19 SNPs; OR: 0.91; 95% CI: 0.42, 1.98) nor the unrestricted HDL-C allele score adjusted for triglycerides, LDL-C, or statin use (OR: 0.81; 95% CI: 0.44, 1.46) showed a robust association. For triglycerides, the unrestricted allele score (67 SNPs) and the restricted allele score (27 SNPs) were both associated with CHD (OR: 1.62; 95% CI: 1.24, 2.11 and 1.61; 95% CI: 1.00, 2.59, respectively) per 1-log unit increment. However, the unrestricted triglyceride score adjusted for HDL-C, LDL-C, and statin use gave an OR for CHD of 1.01 (95% CI: 0.59, 1.75). Conclusion The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain.
|
|
| 2. |
- Ervasti, J, et al.
(författare)
-
Concurrent trajectories of self-rated health and working hour patterns in health care shift workers: A longitudinal analysis with 8-year follow-up
- 2022
-
Ingår i: Frontiers in public health. - : Frontiers Media SA. - 2296-2565. ; 10, s. 926057-
-
Tidskriftsartikel (refereegranskat)abstract
- The association between health and working hours is hypothesized to be reciprocal, but few longitudinal studies have examined changes in both health and working hour patterns over time. We examined combined trajectories of self-related health and two working hour patterns (working <35 h/week and working night shifts) and the extent to which these trajectories were predicted by employees' lifestyle and mental health.MethodsParticipants of this cohort study with a 8-year follow-up were 5,947 health care shift workers. We linked self-reports of health from three repeated surveys with objective pay-roll based data on working hours. Using group-based multi-trajectory analysis we identified concurrent trajectories for self-rated health and working hour patterns. We examined their associations with baseline lifestyle-related factors (smoking, at-risk alcohol use, obesity, and physical inactivity) and mental health (sleep problems and psychological distress) using multinomial regression analysis.ResultsThree combined trajectories of self-rated health and working <35 h/week and four combined trajectories of self-rated health and night work were identified. Unhealthy lifestyle and poor mental health were associated with trajectories of moderate and declining health. Sleep problems were linked with working <35 h/week. Younger age and good mental health were associated with a combined trajectory of good health and continued night shift work.ConclusionTrajectories of suboptimal and declining health are associated with trajectories of reducing working hours and leaving night work, and are more common in employees with unhealthy lifestyle, sleep problems, and psychological distress.
|
|
| 3. |
- Kettunen, J. A., et al.
(författare)
-
Valence electronic structure and photofragmentation of 1,1,1,2-tetrafluoroethane (CF3-CH2F)
- 2012
-
Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 85:6
-
Tidskriftsartikel (refereegranskat)abstract
- The electronic structure and fragmentation of the hydrofluorocarbon compound 1,1,1,2-tetrafluoroethane (CF3-CH2F) were studied using spectroscopical methods and quantum chemical calculations. Valence photoelectron spectra and the ionic fragmentation products were recorded with synchrotron radiation in the vacuum ultraviolet (VUV) region. The geometric and electronic structures of the CF3-CH2F molecule were calculated using the complete active space perturbation theory of second order. The calculated vertical ionization energies were used to interpret the experimental photoelectron spectrum. VUV photodissociation of the sample molecule was studied with photoelectron-photoion coincidence spectroscopy. Coincident ion yields are shown for several cations as a function of electron binding energy. The experimental data are discussed in comparison with theory and previous work.
|
|
| 4. |
- Ceolin, Denis, et al.
(författare)
-
Effect of the Cl2p core orbital excitation on the nuclear dynamics of the three dichloroethylene isomers
- 2011
-
Ingår i: Journal of Electron Spectroscopy and Related Phenomena. - : Elsevier BV. - 0368-2048 .- 1873-2526. ; 184:1-2, s. 24-28
-
Tidskriftsartikel (refereegranskat)abstract
- In this article, we present the X-ray absorption spectra of the three isomers of dichloroethylene C2H2Cl2 in the vicinity of the chlorine L-2 and L-3 edges. These isomers were excited along the first Cl2p to lowest unoccupied molecular orbital transition and an analysis of the corresponding resonant Auger spectra shows that the C-Cl bond can break before the electronic decay. An investigation of a possible Auger Doppler-like effect is also presented.
|
|
| 5. |
- Coreno, M., et al.
(författare)
-
Vis-UV fluorescence studies of fragments resulting from the relaxation of molecular core hole states
- 2007
-
Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; 76:3, s. C90-C95
-
Tidskriftsartikel (refereegranskat)abstract
- The absorption of soft x-ray radiation induces neutral and ionic core hole states in molecules. The relaxation of such states typically leads to a multi-step process, at the end of which photons in the visible and UV range can also be emitted from fragments. In this paper, we present results on Balmer and Lyman emission that originates from excited H atoms produced at the K-edge of the water, ammonia and methane molecules. Dissociation pathways leading to fluorescence emission are discussed.
|
|
| 6. |
- Decleva, P, et al.
(författare)
-
Shake-up transitions in S 2p, S 2s and F 1s photoionization of the SF6 molecule
- 2009
-
Ingår i: Journal of Physics B. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 42:5, s. 055102-
-
Tidskriftsartikel (refereegranskat)abstract
- Shake-up transitions occurring upon core photoionization in the SF6 molecule have been studied experimentally and theoretically. The S 2p, S 2s and F 1s shake-up satellite photoelectron spectra were measured using A1 Ka radiation at 1487 eV photon energy. They have been interpreted with the aid of ab initio configuration interaction calculations in the sudden-limit approximation. For the S 2p spectrum, conjugate shake-up transitions were also calculated. Clear evidence of conjugate processes is observed in the S 2p shake-up spectrum measured at 230 eV photon energy. The experimental and theoretical S 2p and S 2s shake-up spectra show very similar structures mainly due to orbital relaxation involving S 3s and 3p participation. For the calculation of the F 1s shake-up spectrum, the symmetry lowering of the molecule in the final states was considered, resulting in a good agreement with the experiment.
|
|
| 7. |
- Heikkila, Katriina, et al.
(författare)
-
Job Strain and Tobacco Smoking : An Individual-Participant Data Meta-Analysis of 166 130 Adults in 15 European Studies
- 2012
-
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:7
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Tobacco smoking is a major contributor to the public health burden and healthcare costs worldwide, but the determinants of smoking behaviours are poorly understood. We conducted a large individual-participant meta-analysis to examine the extent to which work-related stress, operationalised as job strain, is associated with tobacco smoking in working adults. Methodology and Principal Findings: We analysed cross-sectional data from 15 European studies comprising 166 130 participants. Longitudinal data from six studies were used. Job strain and smoking were self-reported. Smoking was harmonised into three categories never, ex- and current. We modelled the cross-sectional associations using logistic regression and the results pooled in random effects meta-analyses. Mixed effects logistic regression was used to examine longitudinal associations. Of the 166 130 participants, 17% reported job strain, 42% were never smokers, 33% ex-smokers and 25% current smokers. In the analyses of the cross-sectional data, current smokers had higher odds of job strain than never-smokers (age, sex and socioeconomic position-adjusted odds ratio: 1.11, 95% confidence interval: 1.03, 1.18). Current smokers with job strain smoked, on average, three cigarettes per week more than current smokers without job strain. In the analyses of longitudinal data (1 to 9 years of follow-up), there was no clear evidence for longitudinal associations between job strain and taking up or quitting smoking. Conclusions: Our findings show that smokers are slightly more likely than non-smokers to report work-related stress. In addition, smokers who reported work stress smoked, on average, slightly more cigarettes than stress-free smokers.
|
|
| 8. |
- Kivimaeki, A., et al.
(författare)
-
On the production of N-2(+) ions at the N 1s edge of the nitrogen molecule
- 2013
-
Ingår i: Physica Scripta. - : IOP Publishing. - 0031-8949 .- 1402-4896. ; 87:6
-
Tidskriftsartikel (refereegranskat)abstract
- The N-2(+) ion yield of the N-2 molecule has been measured at the N 1s -> Rydberg excitations. It displays Fano-type line shapes due to interference between direct outer-valence photoionization and participator decay of the core-excited Rydberg states. The N-2(+) ion yield is compared with the total intensity of the outer-valence photoelectron lines obtained recently with electron spectroscopy (Kivimaki et al 2012 Phys. Rev. A 86 012516). The increasing difference between the two curves at the higher core-to-Rydberg excitations is most likely due to soft x-ray emission processes that are followed by autoionization. The results also suggest that resonant Auger decay from the core-valence doubly excited states contributes to the N-2(+) ion yield at the photon energies that are located on both sides of the N 1s ionization limit.
|
|
| 9. |
- Kivimaeki, A., et al.
(författare)
-
Valence photoionization of the N-2 molecule in the region of the N 1s -> Rydberg excitations
- 2012
-
Ingår i: Physical Review A (Atomic, Molecular and Optical Physics). - 1050-2947. ; 86:1
-
Tidskriftsartikel (refereegranskat)abstract
- The intensities of the X and A valence photoelectron lines of N-2 have been found to display Fano line shapes as a function of photon energy around the N 1s -> Rydberg excitations. The vibrational intensity distributions of these photoelectron lines change at the N 1s -> 3s sigma and 3p pi resonances. These effects indicate interference between direct and resonant photoionization channels. Our numerical simulations reproduce quite well the experimental results.
|
|
| 10. |
|
|
