| 1. |
- Munk, P., et al.
(författare)
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Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
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| 2. |
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| 3. |
- Richter, M. C., et al.
(författare)
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NiFe2O4 and Fe3O4 studied by XMCD and resonant photoemission
- 2009
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Ingår i: The European Physical Journal. Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 169, s. 175-180
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Tidskriftsartikel (refereegranskat)abstract
- X-ray magnetic circular dichroism and resonant photoemission at the Fe and Ni L-2,L-3 edges have been used to investigate the electronic structure of NiFe2O4 (NFO) thin films. The results, when compared to those obtained on Fe3O4, indicate that in a 12 nm NFO film the Ni atoms occupy mainly B sites, as in bulk NFO, and that a decrease in the thickness of the film results in a modi. cation of the nickel hybridization.
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| 4. |
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| 5. |
- Behrens, Manja, et al.
(författare)
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The Shapes of Z-alpha(1)-Antitrypsin Polymers in Solution Support the C-Terminal Domain-Swap Mechanism of Polymerization
- 2014
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Ingår i: Biophysical Journal. - : Elsevier BV. - 1542-0086 .- 0006-3495. ; 107:8, s. 1905-1912
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Tidskriftsartikel (refereegranskat)abstract
- Emphysema and liver cirrhosis can be caused by the Z mutation (Glu342Lys) in the serine protease inhibitor alpha 1-antitrypsin (alpha 1AT), which is found in more than 4% of the Northern European population. Homozygotes experience deficiency in the lung concomitantly with a massive accumulation of polymers within hepatocytes, causing their destruction. Recently, it was proposed that Z-alpha 1AT polymerizes by a C-terminal domain swap. In this study, small-angle x-ray scattering (SAXS) was used to characterize Z-alpha 1AT polymers in solution. The data show that the Z-alpha 1AT trimer, tetramer, and pentamer all form ring-like structures in strong support of a common domain-swap polymerization mechanism that can lead to self-terminating polymers.
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| 6. |
- Carabineiro, S A C, et al.
(författare)
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Resonant photoemission of N2O on Ir(110)
- 2004
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Ingår i: Surface Review and Letters. - 0218-625X. ; 11:4-5, s. 385-389
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Tidskriftsartikel (refereegranskat)abstract
- The adsorption of N2O on Ir(110) was investigated with high-resolution resonant photoemission at 135 K. The results obtained show evidence of molecular adsorption of N2O, along with some dissociation. It is found that the nitrogen photoemission spectra measured at the terminal and central nitrogen energy positions of the N2O/Ir(110) system are equivalent to those of N2O in the gas phase. In contrast, the oxygen spectrum shows little resemblance to the gas phase oxygen spectrum of N2O. In the nitrogen resonant photoemission spectra one can only discover resonant behavior with constant binding energy peaks. In contrast, the oxygen resonant photoemission spectra shows dominantly Auger behavior with peaks at constant kinetic energies. Both observations reveal that the oxygen is bonded to the Ir surface. A systematic study as a function of coverage and temperature and a comparison with other surfaces differing in structure and composition is needed to understand the variations in the adsorption behavior of N2O On metal surfaces.
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| 7. |
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| 8. |
- Pichler, T, et al.
(författare)
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Proof for trivalent Sc ions in Sc-2 @ C-84 from high-energy spectroscopy
- 2000
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Ingår i: PHYSICAL REVIEW B. - : AMERICAN PHYSICAL SOC. - 0163-1829. ; 62:19, s. 13196-13201
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Tidskriftsartikel (refereegranskat)abstract
- The electronic structure and the valency of the Sc ions in the endohedral dimetallofullerene Sc-2 @ C-84 with D-2d symmetry are probed using high-energy spectroscopy. Comparison of the Sc 2p --> 3d x-ray-absorption spectrum with calculated ionic multiplet
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