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- 2019
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Zayats, T, et al.
(författare)
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Exome chip analyses in adult attention deficit hyperactivity disorder
- 2016
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Ingår i: Translational Psychiatry. - : Nature Publishing Group. - 2158-3188. ; 6:10
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Tidskriftsartikel (refereegranskat)abstract
- Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable childhood-onset neuropsychiatric condition, often persisting into adulthood. The genetic architecture of ADHD, particularly in adults, is largely unknown. We performed an exome-wide scan of adult ADHD using the Illumina Human Exome Bead Chip, which interrogates over 250 000 common and rare variants. Participants were recruited by the International Multicenter persistent ADHD CollaboraTion (IMpACT). Statistical analyses were divided into 3 steps: (1) gene-level analysis of rare variants (minor allele frequency (MAF)<1%); (2) single marker association tests of common variants (MAF⩾1%), with replication of the top signals; and (3) pathway analyses. In total, 9365 individuals (1846 cases and 7519 controls) were examined. Replication of the most associated common variants was attempted in 9847 individuals (2077 cases and 7770 controls) using fixed-effects inverse variance meta-analysis. With a Bonferroni-corrected significance level of 1.82E-06, our analyses of rare coding variants revealed four study-wide significant loci: 6q22.1 locus (P=4.46E-08), where NT5DC1 and COL10A1 reside; the SEC23IP locus (P=6.47E-07); the PSD locus (P=7.58E-08) and ZCCHC4 locus (P=1.79E-06). No genome-wide significant association was observed among the common variants. The strongest signal was noted at rs9325032 in PPP2R2B (odds ratio=0.81, P=1.61E-05). Taken together, our data add to the growing evidence of general signal transduction molecules (NT5DC1, PSD, SEC23IP and ZCCHC4) having an important role in the etiology of ADHD. Although the biological implications of these findings need to be further explored, they highlight the possible role of cellular communication as a potential core component in the development of both adult and childhood forms of ADHD.
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| 3. |
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| 4. |
- Manninen, Mikael A., et al.
(författare)
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First encounters in the north : cultural diversity and gene flow in Early Mesolithic Scandinavia
- 2021
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Ingår i: Antiquity. - : Antiquity Publications. - 0003-598X .- 1745-1744. ; 95:380, s. 310-328
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Tidskriftsartikel (refereegranskat)abstract
- Population genetic studies often overlook the evidence for variability and change in past material culture. Here, the authors use a Mesolithic example to demonstrate the importance of integrating archaeological evidence into the interpretation of the Scandinavian hunter-gatherer genetic group. Genetic studies conclude that this group resulted from two single-event dispersals into Scandinavia before 7500 BC. Archaeological evidence, however, shows at least six immigration events pre-dating the earliest DNA, and that the first incoming groups arrived in Scandinavia before 9000 BC. The findings underline the importance of conducting careful archaeological analysis of prehistoric human dispersal in tandem with the study of ancient population genomics.
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| 5. |
- Toven, K., et al.
(författare)
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Use of chlorine dioxide and ozone in combination in prebleaching
- 2002
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Ingår i: Journal of Pulp and Paper Science (JPPS). - 0826-6220. ; 28:9, s. 305-310
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Tidskriftsartikel (refereegranskat)abstract
- (DZ)Eo prebleaching of oxygen-delignified softwood kraft pulp gave a synergistic delignification effect compared to the effect of chlorine dioxide and ozone Separately, and the (DZ)Eo process was somewhat better than (ZD)Eo prebleaching in terms of delignification. The solubilization of the lignin in chlorine dioxide and ozone bleaching seems to be governed by the large number of carboxyl groups introduced into the lignin structure. The efficient delignification obtained in (DZ)Eo prebleaching may be explained by the ability of chlorine dioxide and ozone to degrade different Apes of lignin structures. Whereas chlorine dioxide mainly degrades phenolic lignin structures, ozone is capable of degrading both phenolic and non-phenolic lignin structures. The (DZ) treatment initially allows chlorine dioxide to degrade the phenolic lignin structures, and leaves the non-phenolic and less reactive lignin structures for the ozone treatment.
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