| 1. |
- Thill, Serge, et al.
(författare)
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Driver adherence to recommendations from support systems improves if the systems explain why they are given : A simulator study
- 2018
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Ingår i: Transportation Research Part F. - : Elsevier BV. - 1369-8478 .- 1873-5517. ; 56, s. 420-435
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a large-scale simulator study on driver adherence to recommendations given by driver support systems, specifically eco-driving support and navigation support. 123 participants took part in this study, and drove a vehicle simulator through a pre-defined environment for a duration of approximately 10 min. Depending on the experimental condition, participants were either given no eco-driving recommendations, or a system whose provided support was either basic (recommendations were given in the form of an icon displayed in a manner that simulates a heads-up display) or informative (the system additionally displayed a line of text justifying its recommendations). A navigation system that likewise provided either basic or informative support, depending on the condition, was also provided. Effects are measured in terms of estimated simulated fuel savings as well as engine braking/coasting behaviour and gear change efficiency. Results indicate improvements in all variables. In particular, participants who had the support of an eco-driving system spent a significantly higher proportion of the time coasting. Participants also changed gears at lower engine RPM when using an eco-driving support system, and significantly more so when the system provided justifications. Overall, the results support the notion that providing reasons why a support system puts forward a certain recommendation improves adherence to it over mere presentation of the recommendation. Finally, results indicate that participants’ driving style was less eco-friendly if the navigation system provided justifications but the eco-system did not. This may be due to participants considering the two systems as one whole rather than separate entities with individual merits. This has implications for how to design and evaluate a given driver support system since its effectiveness may depend on the performance of other systems in the vehicle.
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| 2. |
- Andersson, Jonas, et al.
(författare)
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Hello human, can you read my mind?
- 2017
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Ingår i: ERCIM News. - Sophia Antipolis Cedex : European Research Consortium for Informatics and Mathematics (ERCIM). - 0926-4981 .- 1564-0094. ; :109, s. 36-37
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Forskningsöversikt (refereegranskat)abstract
- For safety reasons, autonomous vehicles should communicate their intent rather than explicitly invite people to act. At RISE Viktoria in Sweden, we believe this simple design principle will impact how autonomous vehicles are experienced in the future.
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| 3. |
- Bonagas, Nadilly, et al.
(författare)
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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
- 2022
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Ingår i: NATURE CANCER. - : Springer Science and Business Media LLC. - 2662-1347. ; 3:2, s. 156-
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Tidskriftsartikel (refereegranskat)abstract
- The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical development. In the present study, we demonstrate a role for MTHFD2 in DNA replication and genomic stability in cancer cells, and perform a drug screen to identify potent and selective nanomolar MTHFD2 inhibitors; protein cocrystal structures demonstrated binding to the active site of MTHFD2 and target engagement. MTHFD2 inhibitors reduced replication fork speed and induced replication stress followed by S-phase arrest and apoptosis of acute myeloid leukemia cells in vitro and in vivo, with a therapeutic window spanning four orders of magnitude compared with nontumorigenic cells. Mechanistically, MTHFD2 inhibitors prevented thymidine production leading to misincorporation of uracil into DNA and replication stress. Overall, these results demonstrate a functional link between MTHFD2-dependent cancer metabolism and replication stress that can be exploited therapeutically with this new class of inhibitors. Helleday and colleagues describe a nanomolar MTHFD2 inhibitor that causes replication stress and DNA damage accumulation in cancer cells via thymidine depletion, demonstrating a potential therapeutic strategy in AML tumors in vivo.
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| 4. |
- Bout, Martijn, et al.
(författare)
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A head-mounted display to support teleoperations of shared automated vehicles
- 2017
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Ingår i: AutomotiveUI 2017 - 9th International ACM Conference on Automotive User Interfaces and Interactive Vehicular Applications, Adjunct Proceedings. - New York, NY, USA : Association for Computing Machinery, Inc. - 9781450351515 ; , s. 62-66
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Konferensbidrag (refereegranskat)abstract
- Automated driving systems will be severely challenged in the unpredictable conditions of mixed traffic. Consequently, some form of human support remains essential in the foreseeable future. This challenge is especially true for Shared Automated Vehicles (SAVs), as these vehicles will likely not include any human driver on-board. When an SAV will encounter a scenario it cannot handle, a remote human operator will need to intervene and help the vehicle and its passengers. In this study a user-centred design approach is used to study whether a Head-Mounted Display (HMD) interface can support such operators and provide them with additional spatial awareness. Two prototypes (an HMD and a computer display) are developed and evaluated using pre-recorded real-world scenarios. Twelve participants assessed three possible scenarios a remote operator may encounter. Among participants, the study found evidence of strong implicit spatial awareness when using an HMD interface.
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| 5. |
- Böckle, Marc-Philipp, et al.
(författare)
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SAV2P - Exploring the impact of an interface for shared automated vehicles on pedestrians' experience
- 2017
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Ingår i: AutomotiveUI 2017 - 9th International ACM Conference on Automotive User Interfaces and Interactive Vehicular Applications, Adjunct Proceedings. - New York, NY, USA : ACM. - 9781450351515 - 9781450351508 ; , s. 136-140
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Konferensbidrag (refereegranskat)abstract
- To study future communication needs between pedestrians and shared automated vehicles (SAVs), an interface that communicates the intentions of SAVs to pedestrians was designed and implemented in a virtual reality (VR) environment. This enabled the exploration of behaviors and experiences of 34 pedestrians when encountering SAVs, both with and without the interface, in several street crossing situations. All pedestrians assessed the level of perceived safety and comfort directly after each encounter with the SAV. The results show that the pedestrians' level of perceived safety and comfort is higher in encounters with the interface than in encounters without the interface. This may have a positive influence on the acceptance of SAVs, and implies that future SAVs may gain from this, or similar interface.
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| 6. |
- Dey, Debargha, et al.
(författare)
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Workshop on Methodology : Evaluating Interactions Between Automated Vehicles and Other Road Users—What Works in Practice?
- 2018
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Ingår i: Proceedings of the 10th International Conference on Automotive User Interfaces and Interactive Vehicular Applications. - New York, NY, USA : ACM. - 9781450359474 ; , s. 17-22
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Konferensbidrag (refereegranskat)abstract
- Methods and metrics for studying interactions between automated vehicles and other road users in their vicinity, such as pedestrians, cyclists and non-automated vehicles, are not established yet. This workshop focuses on identifying the strengths and weaknesses of various methodologies that could potentially be used to study such interactions. The objective lies in determining the proper experimental design, sensitivity of metrics for measuring user behavior, ecological validity, generalizability of findings, extraction of insights regarding how findings can be translated into actionable requirements, and the alternatives for conducting longitudinal field studies. It will be of an interactive nature and involve hands-on activities. The workshop will consolidate existing knowledge, identify recurring issues, and explore the path towards resolving these issues. The outcome will be compiled into a paper to share this valuable knowledge with a broader research community.
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| 7. |
- Giordanetto, Fabrizio, et al.
(författare)
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Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1 H-indol-1-yl]pyridine-2-yl}propanoic Acid
- 2018
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Ingår i: ACS Medicinal Chemistry Letters. - : American Chemical Society. - 1948-5875. ; 9:7, s. 600-605
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Tidskriftsartikel (refereegranskat)abstract
- A lead generation campaign identified indole-based sPLA2-X inhibitors with a promising selectivity profile against other sPLA2 isoforms. Further optimization of sPLA2 selectivity and metabolic stability resulted in the design of (-)-17, a novel, potent, and selective sPLA2-X inhibitor with an exquisite pharmacokinetic profile characterized by high absorption and low clearance, and low toxicological risk. Compound (-)-17 was tested in an ApoE-/- murine model of atherosclerosis to evaluate the effect of reversible, pharmacological sPLA2-X inhibition on atherosclerosis development. Despite being well tolerated and achieving adequate systemic exposure of mechanistic relevance, (-)-17 did not significantly affect circulating lipid and lipoprotein biomarkers and had no effect on coronary function or histological markers of atherosclerosis.
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| 8. |
- Habibovic, Azra, et al.
(författare)
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Communicating Intent of Automated Vehicles to Pedestrians.
- 2018
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Ingår i: Frontiers in Psychology. - Lausanne : Frontiers Media SA. - 1664-1078. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- While traffic signals, signs, and road markings provide explicit guidelines for those operating in and around the roadways, some decisions, such as determinations of "who will go first," are made by implicit negotiations between road users. In such situations, pedestrians are today often dependent on cues in drivers' behavior such as eye contact, postures, and gestures. With the introduction of more automated functions and the transfer of control from the driver to the vehicle, pedestrians cannot rely on such non-verbal cues anymore. To study how the interaction between pedestrians and automated vehicles (AVs) might look like in the future, and how this might be affected if AVs were to communicate their intent to pedestrians, we designed an external vehicle interface called automated vehicle interaction principle (AVIP) that communicates vehicles' mode and intent to pedestrians. The interaction was explored in two experiments using a Wizard of Oz approach to simulate automated driving. The first experiment was carried out at a zebra crossing and involved nine pedestrians. While it focused mainly on assessing the usability of the interface, it also revealed initial indications related to pedestrians' emotions and perceived safety when encountering an AV with/without the interface. The second experiment was carried out in a parking lot and involved 24 pedestrians, which enabled a more detailed assessment of pedestrians' perceived safety when encountering an AV, both with and without the interface. For comparison purposes, these pedestrians also encountered a conventional vehicle. After a short training course, the interface was deemed easy for the pedestrians to interpret. The pedestrians stated that they felt significantly less safe when they encountered the AV without the interface, compared to the conventional vehicle and the AV with the interface. This suggests that the interface could contribute to a positive experience and improved perceived safety in pedestrian encounters with AVs - something that might be important for general acceptance of AVs. As such, this topic should be further investigated in future studies involving a larger sample and more dynamic conditions.
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| 9. |
- Habibovic, Azra, et al.
(författare)
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External Vehicle Interfaces for Communication with Other Road Users?
- 2019
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Ingår i: Road Vehicle Automation 5. - Cham : Springer. - 9783319948959 - 9783319948966 ; , s. 91-102
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Bokkapitel (refereegranskat)abstract
- How to ensure trust and societal acceptance of automated vehicles (AVs) is a widely-discussed topic today. While trust and acceptance could be influenced by a range of factors, one thing is sure: the ability of AVs to safely and smoothly interact with other road users will play a key role. Based on our experiences from a series of studies, this paper elaborates on issues that AVs may face in interactions with other road users and whether external vehicle interfaces could support these interactions. Our overall conclusion is that such interfaces may be beneficial in situations where negotiation is needed. However, these benefits, and potential drawbacks, need to be further explored to create a common language, or standard, for how AVs should communicate with other road users.
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| 10. |
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