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- af Klint, Johan, 1939-
(författare)
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The Barabudur : A Synopsis of Buddhism
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this PhD-dissertation is – on the one hand – to present in a critical and comprehensive manner an update of recent findings among Western scholars regarding the Barabudur monument and its illustrations of various Buddhist traditions, and – on the other hand – to throw some light on some of the outstanding issues regarding this monument. Focus has been laid on the religious aspects with a view of ascertaining which forms of Buddhism are most prominently represented on the monument.The Barabudur is the largest Buddhist monument in the world – being built on Central Java during the late eighth century CE. The Barabudur is constructed in four successively higher galleries with an area on top with three round terraces. The terraces encompass 72 latticed stupas, each containing Buddha Vairocana in dharmacakramudra large stupa is in the center. Each side of the squarely built monument is at the ground level around 123 meters. The height of the monument is believed to originally have been 41.81 meters. The walls and the balustrades of the galleries encompass 1,460 bas-reliefs representing various sutras, such as the Mahakarmavibhanga Sutra, the Lalitavistara, the Gandavyuha Sutra, the Dasabhumika Sutra and the Bhadracari. In addition, the Barabudur seems also to have been influenced by ideas from the ensuing Indonesian esoteric text the Sang Hyang Kamahayanikan, as well as by the esoteric Buddhist texts of the Mahavairocana Sutra, the Tattvasamgraha and the Prajnaparamita in 150 verses. The Barabudur thus presents aspects from the main three Buddhist traditions – the Sravakayana, the Mahayana and an early esoteric form of the Vajrayana.The main problem in studying the Barabudur is the lack of historical information. No dedicatory inscription has yet been found. The Barabudur was built during the Sailendra interregnum on Java. Their contacts with the Abhayagirivihara on Sri Lanka and with the Pala dynasty in Bengal, indicate that some early form of Vajrayana Buddhism existed on Java during the eighth century CE. In addition, some concepts from the esoteric Buddhism developed by the Three Monks in China during this period could well also have been introduced on Java.The Barabudur, together with the Candi Mendut, are supposed to represent the Twin-mandala – thus representing the “non-duality” between “Truth” and “Wisdom”. Dharmakaya Mahavairocana is in the center of both these Twin-mandalas symbolizing the amalavijnana.In conclusion, the Barabudur may be regarded as a holy monument, where the Buddha is present, and where the devotee may be taught directly by the Buddha.
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- Bonow, Johan M., et al.
(författare)
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A multi-disciplinary study of Phanerozoic landscape development in West Greenland
- 2007
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Ingår i: Geological Survey of Denmark and Greenland Bulletin: Review of Survey activities 2006. - 1604-8156. ; :13, s. 33-36
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Tidskriftsartikel (refereegranskat)abstract
- The western margin of the Greenland craton has been muchless stable in the Phanerozoic than previously thought. Thisnew insight has come from close integration of independentdata sets: geomorphological analysis of large-scale landscapes,apatite fission track analysis (AFTA), onshore and offshorestratigraphy and analysis of onshore fault and fracture sys -tems. Each data set records specific and unique parts of theevent chronology and is equally important to establish a con-sistent model. A key area for understanding the Mesozoic-Cenozoic landscape evolution and into the present is theuplifted part of the Nuussuaq Basin, where remnants of pla-nation surfaces cut across the Cretaceous to Eocene sedimen-tary and volcanic rocks. Our integrated analysis concludedthat the West Greenland mountains were formed by lateNeogene tectonic uplift (Fig. 1) and also provided newinsight into early Phanerozoic development. To understandour model, we present the different methods and the resultsthat can be deduced from them.
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- Ekman, Martin, et al.
(författare)
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Protein expression profiles in an endosymbiotic cyanobacterium revealed by a proteomic approach
- 2006
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Ingår i: Molecular Plant-Microbe Interactions. - 0894-0282 .- 1943-7706. ; 19:11, s. 1251-1261
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Tidskriftsartikel (refereegranskat)abstract
- Molecular mechanisms behind adaptations in the cyano-bacterium (Nostoc sp.) to a life in endosymbiosis with plants are still not clarified, nor are the interactions between the partners. To get further insights, the proteome of a Nostoc strain, freshly isolated from the symbiotic gland tissue of the angiosperm Gunnera manicata Linden, was analyzed and compared with the proteome of the same strain when free-living. Extracted proteins were separated by two-dimensional gel electrophoresis and were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry combined with tandem mass spectrometry. Even when the higher percentage of differentiated cells (heterocysts) in symbiosis was compensated for, the majority of the proteins detected in the symbiotic cyanobacteria were present in the free-living counterpart, indicating that most cellular processes were common for both stages. However, differential expression profiling revealed a significant number of proteins to be down-regulated or missing in the symbiotic stage, while others were more abundant or only expressed in symbiosis. The differential protein expression was primarily connected to i) cell envelope-associated processes, including proteins involved in exopolysaccharide synthesis and surface and membrane associated proteins, ii) to changes in growth and metabolic activities (C and N), including upregulation of nitrogenase and proteins involved in the oxidative pentose phosphate pathway and downregu-lation of Calvin cycle enzymes, and iii) to the dark, micro-aerobic conditions offered inside the Gunnera gland cells, including changes in relative phycobiliprotein concentrations. This is the first comprehensive analysis of proteins in the symbiotic state.
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- Klint, Elisabeth, et al.
(författare)
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Combined Use of Frameless Neuronavigation and In Situ Optical Guidance in Brain Tumor Needle Biopsies
- 2023
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Ingår i: Brain Sciences. - 2076-3425. ; 13:5
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Tidskriftsartikel (refereegranskat)abstract
- Brain tumor needle biopsies are performed to retrieve tissue samples for neuropathological analysis. Although preoperative images guide the procedure, there are risks of hemorrhage and sampling of non-tumor tissue. This study aimed to develop and evaluate a method for frameless one-insertion needle biopsies with in situ optical guidance and present a processing pipeline for combined postoperative analysis of optical, MRI, and neuropathological data. An optical system for quantified feedback on tissue microcirculation, gray-whiteness, and the presence of a tumor (protoporphyrin IX (PpIX) accumulation) with a one-insertion optical probe was integrated into a needle biopsy kit that was used for frameless neuronavigation. In Python, a pipeline for signal processing, image registration, and coordinate transformation was set up. The Euclidian distances between the pre- and postoperative coordinates were calculated. The proposed workflow was evaluated on static references, a phantom, and three patients with suspected high-grade gliomas. In total, six biopsy samples that overlapped with the region of the highest PpIX peak without increased microcirculation were taken. The samples were confirmed as being tumorous and postoperative imaging was used to define the biopsy locations. A 2.5 ± 1.2 mm difference between the pre- and postoperative coordinates was found. Optical guidance in frameless brain tumor biopsies could offer benefits such as quantified in situ indication of high-grade tumor tissue and indications of increased blood flow along the needle trajectory before the tissue is removed. Additionally, postoperative visualization enables the combined analysis of MRI, optical, and neuropathological data.
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- Klint, Elisabeth, et al.
(författare)
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FluoRa - a System for Combined Fluorescence and Microcirculation Measurements in Brain Tumor Surgery
- 2021
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Ingår i: 2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC). - : IEEE. - 9781728111797 ; , s. 1512-1515
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Konferensbidrag (refereegranskat)abstract
- In brain tumor surgery it is difficult to distinguish the marginal zone with the naked eye. Fluorescence techniques can help identifying tumor tissue in the zone during resection and biopsy procedures. In this paper a novel system for combined real-time measurements of PpIX-fluorescence, microcirculation and tissue grey-whiteness is presented and experimentally evaluated. The system consists of a fluorescence hardware with a sensitive CCD spectrometer for PpIX peak detection, a laser Doppler system, optical probes, and a LabView software. System evaluation was done on static fluorescing material, human skin, and brain tumor tissue. The static material indicates reproducibility, the skin measurements exemplify simultaneous fluorescence and microcirculation measurement in real-time, and the tumor tissue showed PpIX peaks. These decreased over time, as expected, due to photo bleaching. In addition, the system was prepared for clinical use and thus laser- and electrical safety issues were considered. In summary, a system for multiparameter measurements during neurosurgery was successfully evaluated in an experimental environment. As a next step the system will be applied in clinical brain tumor biopsies and resections.
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- Klint, Åsa, et al.
(författare)
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Dying With Unrelieved Pain-Prescription of Opioids Is Not Enough
- 2019
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Ingår i: Journal of Pain and Symptom Management. - : Elsevier BV. - 1873-6513 .- 0885-3924. ; 58:5, s. 1-791
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Fear of pain resonates with most people, in particular, in relation to dying. Despite this, there are still people dying with unrelieved pain.OBJECTIVES: We quantified the risk, and investigated risk factors, for dying with unrelieved pain in a nationwide observational cohort study.METHODS: Using data from Swedish Register of Palliative Care, we analyzed 161,762 expected deaths during 2011-2015. The investigated risk factors included cause of death, place of death, absence of an end-of-life (EoL) conversation, and lack of contact with pain management expertise. Modified Poisson regression models were fitted to estimate risk ratios (RRs) and 95% confidence intervals (CIs) for dying with unrelieved pain.RESULTS: Unrelieved pain during the final week of life was reported for 25% of the patients with pain, despite prescription of opioids PRN in 97% of cases. Unrelieved pain was common both among patients dying of cancer and of nonmalignant chronic diseases. Statistically significant risk factors for unrelieved pain included hospital death (RR = 1.84, 95% CI 1.79-1.88) compared with dying in specialist palliative care, absence of an EoL conversation (RR = 1.42, 95% CI 1.38-1.45), and dying of cancer in the bones (RR = 1.13, 95% CI 1.08-1.18) or lung (RR = 1.10, 95% CI 1.06-1.13) compared with nonmalignant causes.CONCLUSION: Despite almost complete prescription of opioids PRN for patients with pain, patients die with unrelieved pain. Health care providers, hospitals in particular, need to focus more on pain in dying patients. An EoL conversation is one achievable intervention.
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