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Sökning: WFRF:(Kloft C.)

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1.
  • Swat, M. J., et al. (författare)
  • Pharmacometrics Markup Language (PharmML) : Opening New Perspectives for Model Exchange in Drug Development
  • 2015
  • Ingår i: CPT. - : American Society for Clinical Pharmacology & Therapeutics. - 2163-8306. ; 4:6, s. 316-319
  • Tidskriftsartikel (refereegranskat)abstract
    • The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reproducibility of research, and facilitate the reuse of existing model resources. Pharmacometrics Markup Language (PharmML), currently under development by the Drug Disease Model Resources (DDMoRe) consortium, is intended to become an exchange standard in pharmacometrics by providing means to encode models, trial designs, and modeling steps.
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2.
  • Ribba, B, et al. (författare)
  • A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis
  • 2014
  • Ingår i: CPT. - : Wiley. - 2163-8306. ; 3:5, s. 1-10
  • Tidskriftsartikel (refereegranskat)abstract
    • Population modeling of tumor size dynamics has recently emerged as an important tool in pharmacometric research. A series of new mixed-effects models have been reported recently, and we present herein a synthetic view of models with published mathematical equations aimed at describing the dynamics of tumor size in cancer patients following anticancer drug treatment. This selection of models will constitute the basis for the Drug Disease Model Resources (DDMoRe) repository for models on oncology.
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4.
  • Smith, Mike K., et al. (författare)
  • Model Description Language (MDL) : A Standard for Modeling and Simulation
  • 2017
  • Ingår i: CPT. - : WILEY. - 2163-8306. ; 6:10, s. 647-650
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent work on Model Informed Drug Discovery and Development (MID3) has noted the need for clarity in model description used in quantitative disciplines such as pharmacology and statistics. 1-3 Currently, models are encoded in a variety of computer languages and are shared through publications that rarely include original code and generally lack reproducibility. The DDMoRe Model Description Language (MDL) has been developed primarily as a language standard to facilitate sharing knowledge and understanding of models.
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  • Resultat 1-4 av 4

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