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Numrering	Referens	Omslagsbild	Hitta
1.	Bermudez, Christian A, et al. (författare) ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements. 2021 Ingår i: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. - 1557-3117. ; 40:11, s. 1267-1278 Tidskriftsartikel (refereegranskat)abstract Patients with connective tissue disease (CTD) present unique surgical, perioperative, operative, and postoperative challenges related to the often underlying severe pulmonary hypertension and right ventricular dysfunction. The International Society for Heart and Lung Transplantation-supported consensus document on lung transplantation in patients with CTD standardization addresses the surgical challenges and relevant cardiac involvement in the perioperative, operative, and postoperative management in patients with CTD.
2.	Hippich, Markus, et al. (författare) Genetic contribution to the divergence in type 1 diabetes risk between children from the general population and children from affected families 2019 Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 68:4, s. 847-857 Tidskriftsartikel (refereegranskat)abstract The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes (n = 4,573) in the longitudinal TEDDY birth cohort to determine how much of the divergent risk is attributable to genetic enrichment in affected families. Enrichment for susceptible genotypes of multiple type 1 diabetes–associated genes and a novel risk gene, BTNL2, was identified in FDR children compared with GP children. After correction for genetic enrichment, the risks in the FDR and GP children converged but were not identical for multiple islet autoantibodies (hazard ratio [HR] 2.26 [95% CI 1.6–3.02]) and for diabetes (HR 2.92 [95% CI 2.05–4.16]). Convergence varied depending upon the degree of genetic susceptibility. Risks were similar in the highest genetic susceptibility group for multiple islet autoantibodies (14.3% vs .12.7%) and diabetes (4.8% vs. 4.1%) and were up to 5.8-fold divergent for children in the lowest genetic susceptibility group, decreasing incrementally in GP children but not in FDR children. These findings suggest that additional factors enriched within affected families preferentially increase the risk of autoimmunity and type 1 diabetes in lower genetic susceptibility strata.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Lernmark, Åke (1); Toppari, Jorma (1); Mercier, Olaf (1); Hagopian, William A. (1); Rewers, Marian J. (1); She, Jin Xiong (1); visa fler...; Ziegler, Anette G. (1); Akolkar, Beena (1); Krischer, Jeffrey P. (1); Vehik, Kendra (1); Rich, Stephen S (1); Dellgren, Göran, 196 ... (1); Hippich, Markus (1); Bermudez, Christian ... (1); Crespo, Maria M (1); Shlobin, Oksana A (1); Cantu, Edward (1); Mazurek, Jeremy A (1); Levine, Deborah (1); Gutsche, Jacob (1); Kanwar, Manreet (1); Bush, Errol L (1); Heresi, Gustavo A (1); Cypel, Marcello (1); Hadler, Rachel (1); Kolatis, Nicholas (1); Franco, Veronica (1); Benvenuto, Luke (1); Mooney, Joshua (1); Pipeling, Matthew (1); King, Christopher (1); Mannem, Hannah (1); Raman, Sanjeev (1); Knoop, Christiane (1); Douglas, Aaron (1); Beyerlein, Andreas (1); Bonifacio, Ezio (1); Steck, Andrea K. (1); Onengut-Gumuscu, Sun ... (1); Knoop, Jan (1); Winker, Christiane (1); Robertson, Catherine ... (1); visa färre...

Lärosäte: Göteborgs universitet (1); Lunds universitet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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