| 1. |
- Arango-Gonzalez, Blanca, et al.
(författare)
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Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.
- 2014
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:11
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Tidskriftsartikel (refereegranskat)abstract
- Cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration. We studied retinal neurodegeneration using 10 different animal models, covering all major groups of hereditary human blindness (rd1, rd2, rd10, Cngb1 KO, Rho KO, S334ter, P23H, Cnga3 KO, cpfl1, Rpe65 KO), by investigating metabolic processes relevant for different forms of cell death. We show that apoptosis plays only a minor role in the inherited forms of retinal neurodegeneration studied, where instead, a non-apoptotic degenerative mechanism common to all mutants is of major importance. Hallmark features of this pathway are activation of histone deacetylase, poly-ADP-ribose-polymerase, and calpain, as well as accumulation of cyclic guanosine monophosphate and poly-ADP-ribose. Our work thus demonstrates the prevalence of alternative cell death mechanisms in inherited retinal degeneration and provides a rational basis for the design of mutation-independent treatments.
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| 2. |
- Barucca, G., et al.
(författare)
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Study of excited Ξ baryons with the P¯ ANDA detector
- 2021
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Ingår i: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Tidskriftsartikel (refereegranskat)abstract
- The study of baryon excitation spectra provides insight into the inner structure of baryons. So far, most of the world-wide efforts have been directed towards N∗ and Δ spectroscopy. Nevertheless, the study of the double and triple strange baryon spectrum provides independent information to the N∗ and Δ spectra. The future antiproton experiment P¯ANDA will provide direct access to final states containing a Ξ¯ Ξ pair, for which production cross sections up to μb are expected in p¯p reactions. With a luminosity of L= 10 31 cm- 2 s- 1 in the first phase of the experiment, the expected cross sections correspond to a production rate of ∼106events/day. With a nearly 4 π detector acceptance, P¯ANDA will thus be a hyperon factory. In this study, reactions of the type p¯p → Ξ¯ +Ξ∗ - as well as p¯p → Ξ¯ ∗ +Ξ- with various decay modes are investigated. For the exclusive reconstruction of the signal events a full decay tree fit is used, resulting in reconstruction efficiencies between 3 and 5%. This allows high statistics data to be collected within a few weeks of data taking.
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| 3. |
- Barucca, G., et al.
(författare)
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The potential of Λ and Ξ- studies with PANDA at FAIR
- 2021
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Ingår i: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Tidskriftsartikel (refereegranskat)abstract
- The antiproton experiment PANDA at FAIR is designed to bring hadron physics to a new level in terms of scope, precision and accuracy. In this work, its unique capability for studies of hyperons is outlined. We discuss ground-state hyperons as diagnostic tools to study non-perturbative aspects of the strong interaction, and fundamental symmetries. New simulation studies have been carried out for two benchmark hyperon-antihyperon production channels: p¯ p→ Λ¯ Λ and p¯ p→ Ξ¯ +Ξ-. The results, presented in detail in this paper, show that hyperon-antihyperon pairs from these reactions can be exclusively reconstructed with high efficiency and very low background contamination. In addition, the polarisation and spin correlations have been studied, exploiting the weak, self-analysing decay of hyperons and antihyperons. Two independent approaches to the finite efficiency have been applied and evaluated: one standard multidimensional efficiency correction approach, and one efficiency independent approach. The applicability of the latter was thoroughly evaluated for all channels, beam momenta and observables. The standard method yields good results in all cases, and shows that spin observables can be studied with high precision and accuracy already in the first phase of data taking with PANDA.
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| 4. |
- Erni, W., et al.
(författare)
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Technical design report for the PANDA (AntiProton Annihilations at Darmstadt) Straw Tube Tracker
- 2013
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Ingår i: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 49:2
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Tidskriftsartikel (refereegranskat)abstract
- This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the PANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole PANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described.
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| 8. |
- Koch, Christian, 1958, et al.
(författare)
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Radical Sustainable Innovation of office buildings
- 2017
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Ingår i: Proceedings of the 9th Nordic Conference on Construction Economics and Organization. - 9788750211259
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Konferensbidrag (refereegranskat)abstract
- The recent development of technologies, processes and methods of sustainable building has enabled anunprecedented quantum leap in the available solutions. These possibilities could be interpreted asradical, yet they appear at a time as results of a long emergent development. The aim of this paper is tocritically scrutinize, theoretically and empirically, whether radical innovation is occurring insustainable building and what the implication are.The theoretical framework is based on concepts ofradical innovation, inventions and sustainability. Radical sustainable innovation (RSI) should becharacterized by high degrees of newness in the entire life cycle. RSI should offer significantenhancements of known benefits, entirely new benefits, or substantial cost reductions, leading to thetransformation of existing markets, the creation of sustainable growth, and global sustainability. Thus,if buildings were RSI, it would be a shift in paradigm of how buildings are designed, build andused.Serious limitations on these notions are addressed. Buildings are large complex products realisedthrough complex processes and with a long lifecycle. It appears impossible that an entire buildingshould/could be radically new. How to evaluate radicality is a major challenge. It is tentativelyproposed, to use standards for sustainable office buildings. Standards are developed to accelerate thesustainable development but has to some extent come to constrain possibilities of radical innovation.As the criteria of newness is incorporated in standards, going beyond them, could be viewed as radical.Empirically a selection of international cases of office buildings with very high scores of BREEAM,LEED and DGNB are examined. Six selected cases were analysed more in detail, one ofthem,GeelensCounterflow’s Headquarters, being the most outstanding.This handful of office buildingshave reached remarkable higher level of sustainability than contemporary building regulations. Thereisindeed a gap between these few buildings and the majority, making them more radical, yet due toweak social sustainability, they are not evaluated as radical innovation.
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| 9. |
- Koch, Daniel, et al.
(författare)
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2,2 '-Biindolyl Reactions with Aldehydes
- 2016
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Ingår i: European Journal of Organic Chemistry. - : Wiley-VCH Verlag. - 1434-193X .- 1099-0690. ; :7, s. 1389-1396
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Tidskriftsartikel (refereegranskat)abstract
- 2,2'-Biindolyl has been condensed with aromatic and aliphatic aldehydes and products featuring 10-membered rings have been obtained. Thus, benzaldehyde gave compound 24a as the primary product, which readily underwent transannular oxidative coupling to 25a. The structures of both compounds were confirmed by X-ray crystallography. The product from 2,2'-biindolyl and formaldehyde under strongly acidic conditions was slightly different leading to compound 11, whose structure also was confirmed by X-ray crystallography. In this case, two molecules of 2,2'-biindolyl reacted with six molecules of formaldehyde.
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| 10. |
- Koch, Ida Elisabeth, et al.
(författare)
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Isi Foighels dissenser
- 2008
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Ingår i: Denne verden fortjener at blive forandret, Hyldest til Isi Foighel.
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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