| 1. |
- Giustina, Marissa, et al.
(författare)
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A Significant-Loophole-Free Test of Bells Theorem with Entangled Photons
- 2017
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Ingår i: QUANTUM INFORMATION SCIENCE AND TECHNOLOGY III. - : SPIE-INT SOC OPTICAL ENGINEERING. - 9781510613492 - 9781510613485
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Konferensbidrag (refereegranskat)abstract
- John Bells theorem of 1964 states that local elements of physical reality, existing independent of measurement, are inconsistent with the predictions of quantum mechanics (Bell, J. S. (1964), Physics (College. Park. Md). 1 (3), 195). Specifically, correlations between measurement results from distant entangled systems would be smaller than predicted by quantum physics. This is expressed in Bells inequalities. Employing modifications of Bells inequalities, many experiments have been performed that convincingly support the quantum predictions. Yet, all experiments rely on assumptions, which provide loopholes for a local realist explanation of the measurement. Here we report an experiment with polarization-entangled photons that simultaneously closes the most significant of these loopholes. We use a highly efficient source of entangled photons, distributed these over a distance of 58.5 meters, and implemented rapid random setting generation and high-efficiency detection to observe a violation of a Bell inequality with high statistical significance. The merely statistical probability of our results to occur under local realism is less than 3.74 . 10(-31), corresponding to an 11.5 standard deviation effect.
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| 2. |
- Giustina, Marissa, et al.
(författare)
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Significant-Loophole-Free Test of Bells Theorem with Entangled Photons
- 2015
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Ingår i: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 115:25, s. 250401-
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Tidskriftsartikel (refereegranskat)abstract
- Local realism is the worldview in which physical properties of objects exist independently of measurement and where physical influences cannot travel faster than the speed of light. Bells theorem states that this worldview is incompatible with the predictions of quantum mechanics, as is expressed in Bells inequalities. Previous experiments convincingly supported the quantum predictions. Yet, every experiment requires assumptions that provide loopholes for a local realist explanation. Here, we report a Bell test that closes the most significant of these loopholes simultaneously. Using a well-optimized source of entangled photons, rapid setting generation, and highly efficient superconducting detectors, we observe a violation of a Bell inequality with high statistical significance. The purely statistical probability of our results to occur under local realism does not exceed 3.74 x 10(-31), corresponding to an 11.5 standard deviation effect.
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| 3. |
- Crary, John F., et al.
(författare)
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Primary age-related tauopathy (PART) : a common pathology associated with human aging
- 2014
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 128:6, s. 755-766
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Tidskriftsartikel (refereegranskat)abstract
- We recommend a new term, "primary age-related tauopathy" (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer's disease (AD), in the absence of amyloid (A beta) plaques. For these "NFT+/A beta-aEuroe brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as "tangle-only dementia" and "tangle-predominant senile dementia", are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of A beta accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.
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| 4. |
- Dewey, Marc, et al.
(författare)
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Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia
- 2020
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Ingår i: Nature Reviews Cardiology. - : Springer Nature. - 1759-5002 .- 1759-5010. ; 17:7, s. 427-450
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Tidskriftsartikel (refereegranskat)abstract
- Cardiac imaging has a pivotal role in the prevention, diagnosis and treatment of ischaemic heart disease. SPECT is most commonly used for clinical myocardial perfusion imaging, whereas PET is the clinical reference standard for the quantification of myocardial perfusion. MRI does not involve exposure to ionizing radiation, similar to echocardiography, which can be performed at the bedside. CT perfusion imaging is not frequently used but CT offers coronary angiography data, and invasive catheter-based methods can measure coronary flow and pressure. Technical improvements to the quantification of pathophysiological parameters of myocardial ischaemia can be achieved. Clinical consensus recommendations on the appropriateness of each technique were derived following a European quantitative cardiac imaging meeting and using a real-time Delphi process. SPECT using new detectors allows the quantification of myocardial blood flow and is now also suited to patients with a high BMI. PET is well suited to patients with multivessel disease to confirm or exclude balanced ischaemia. MRI allows the evaluation of patients with complex disease who would benefit from imaging of function and fibrosis in addition to perfusion. Echocardiography remains the preferred technique for assessing ischaemia in bedside situations, whereas CT has the greatest value for combined quantification of stenosis and characterization of atherosclerosis in relation to myocardial ischaemia. In patients with a high probability of needing invasive treatment, invasive coronary flow and pressure measurement is well suited to guide treatment decisions. In this Consensus Statement, we summarize the strengths and weaknesses as well as the future technological potential of each imaging modality.
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| 5. |
- Khrennikov, Andrei, et al.
(författare)
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On the equivalence of the Clauser-Horne and Eberhard inequality based tests
- 2014
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Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; T163
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Tidskriftsartikel (refereegranskat)abstract
- Recently, the results of the first experimental test for entangled photons closing the detection loophole (also referred to as the fair sampling loophole) were published (Vienna, 2013). From the theoretical viewpoint the main distinguishing feature of this long-aspired to experiment was that the Eberhard inequality was used. Almost simultaneously another experiment closing this loophole was performed (Urbana-Champaign, 2013) and it was based on the Clauser-Horne inequality (for probabilities). The aim of this note is to analyze the mathematical and experimental equivalence of tests based on the Eberhard inequality and various forms of the Clauser-Horne inequality. The structure of the mathematical equivalence is nontrivial. In particular, it is necessary to distinguish between algebraic and statistical equivalence. Although the tests based on these inequalities are algebraically equivalent, they need not be equivalent statistically, i.e., theoretically the level of statistical significance can drop under transition from one test to another (at least for finite samples). Nevertheless, the data collected in the Vienna test implies not only a statistically significant violation of the Eberhard inequality, but also of the Clauser-Horne inequality (in the ratio-rate form): for both a violation > 60 sigma.
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| 6. |
- Kofler, Florian, et al.
(författare)
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Approaching Peak Ground Truth
- 2023
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Ingår i: Proceedings - International Symposium on Biomedical Imaging. - 1945-7928 .- 1945-8452. - 9781665473583
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Konferensbidrag (refereegranskat)abstract
- Machine learning models are typically evaluated by computing similarity with reference annotations and trained by maximizing similarity with such. Especially in the biomedical domain, annotations are subjective and suffer from low inter-and intra-rater reliability. Since annotations only reflect one interpretation of the real world, this can lead to sub-optimal predictions even though the model achieves high similarity scores. Here, the theoretical concept of Peak Ground Truth (PGT) is introduced. PGT marks the point beyond which an increase in similarity with the reference annotation stops translating to better Real World Model Performance (RWMP). Additionally, a quantitative technique to approximate PGT by computing inter- and intra-rater reliability is proposed. Finally, four categories of PGT-aware strategies to evaluate and improve model performance are reviewed.
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| 7. |
- Kofler, Johannes, et al.
(författare)
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Requirements for a loophole-free photonic Bell test using imperfect setting generators
- 2016
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - : American Physical Society. - 1050-2947 .- 1094-1622. ; 93:3, s. 032115-
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Tidskriftsartikel (refereegranskat)abstract
- Experimental violations of Bell inequalities are in general vulnerable to so-called loopholes. In this work, we analyze the characteristics of a loophole-free Bell test with photons, closing simultaneously the locality, freedom-of-choice, fair-sampling (i.e., detection), coincidence-time, and memory loopholes. We pay special attention to the effect of excess predictability in the setting choices due to nonideal random-number generators. We discuss necessary adaptations of the Clauser-Horne and Eberhard inequality when using such imperfect devices and-using Hoeffdings inequality and Doobs optional stopping theorem-the statistical analysis in such Bell tests.
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| 8. |
- Kovacs, Gabor G., et al.
(författare)
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Aging-related tau astrogliopathy (ARTAG) : harmonized evaluation strategy
- 2016
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 0001-6322 .- 1432-0533. ; 131:1, s. 87-102
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Tidskriftsartikel (refereegranskat)abstract
- Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.
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| 9. |
- Kovacs, Gabor G., et al.
(författare)
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Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)
- 2017
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Ingår i: Journal of Neuropathology and Experimental Neurology. - : Oxford University Press (OUP). - 0022-3069 .- 1554-6578. ; 76:7, s. 605-619
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Tidskriftsartikel (refereegranskat)abstract
- Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal lobar degeneration tauopathies we evaluated how consistently neuropathologists recognize (1) different astroglial tau immunoreactivities, including those of ARTAG and those associated with primary tauopathies (Study 1); (2) ARTAG types (Study 2A); and (3) ARTAG severity (Study 2B). Microphotographs and scanned sections immunostained for phosphorylated tau (AT8) were made available for download and preview. Percentage of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for Study 1 was > 60% with a kappa value of 0.55 (95% CI 0.433-0.645). Moderate agreement (> 90%, kappa 0.48, 95% CI 0.457-0.900) was reached in Study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa 0.37-0.72), whereas fair agreement (kappa 0.40, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa 0.60, 95% CI 0.534-0.653) among raters. Our study supports the application of the current harmonized evaluation strategy for ARTAG with a slight modification of the evaluation of its severity.
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| 10. |
- Larsson, Jan-Åke, et al.
(författare)
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Bell-inequality violation with entangled photons, free of the coincidence-time loophole
- 2014
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - : American Physical Society. - 1050-2947 .- 1094-1622. ; 90:3, s. 032107-
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Tidskriftsartikel (refereegranskat)abstract
- In a local realist model, physical properties are defined prior to and independent of measurement and no physical influence can propagate faster than the speed of light. Proper experimental violation of a Bell inequality would show that the world cannot be described with such a model. Experiments intended to demonstrate a violation usually require additional assumptions that make them vulnerable to a number of "loopholes." In both pulsed and continuously pumped photonic experiments, an experimenter needs to identify which detected photons belong to the same pair, giving rise to the coincidence-time loophole. Here, via two different methods, we derive Clauser-Horne- and Eberhard-type inequalities that are not only free of the fair-sampling assumption (thus not being vulnerable to the detection loophole), but also free of the fair-coincidence assumption (thus not being vulnerable to the coincidence-time loophole). Both approaches can be used for pulsed as well as for continuously pumped experiments. Moreover, as they can also be applied to already existing experimental data, we finally show that a recent experiment [Giustina et al., Nature (London) 497, 227 (2013)] violated local realism without requiring the fair-coincidence assumption.
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