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- Andre, Kadri, et al.
(författare)
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SERT and NET polymorphisms, temperament and antidepressant response
- 2015
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Ingår i: Nordic Journal of Psychiatry. - : Informa UK Limited. - 0803-9488 .- 1502-4725. ; 69:7, s. 531-538
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Tidskriftsartikel (refereegranskat)abstract
- Background: The genetic variations in norepinephrine transporter (NET) and serotonin transporter (SERT) genes have been associated with personality traits, several psychiatric disorders and the efficacy of antidepressant treatment. Aims: We investigated the separate effects and possible interactions between NET T-182C (rs2242446) and SERT 5-HTTLPR (rs4795541) polymorphisms on selective serotonin reuptake inhibitors (SSRI) treatment response and temperamental traits assessed by the Temperament and Character Inventory (TCI) in a clinical sample of subjects with major depressive disorder (MDD). Methods: Our sample of 97 patients with major depression completed the 107-item TCI temperament questionnaire (version IX) at the initial assessment of the study and after 6 weeks of follow-up. All subjects received selective SSRI medications. Temperament dimension scores at baseline (1) and endpoint (2) during antidepressant treatment were analyzed between NET and SERT genotypes. Results: SS-genotype of 5-HTTLPR was associated with higher baseline Persistence scores than SL- or LL-genotype. A corresponding but weaker association was found at endpoint. No differences were found between 5-HTTLPR genotypes and other temperament dimensions and 5-HTTLPR genotypes had no effect on treatment response. Conclusions: Our results suggest that the SS-genotype of 5-HTTLPR is associated with Persistence scores in patients with MDD. Higher Persistence could be viewed as a negative trait when recovering from stress and its association with short and "weaker" S-allele may be related to less efficient serotonin neurotransmission, possibly resulting in less effective coping strategies on a behavioral level.
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| 2. |
- Illi, Ari, et al.
(författare)
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Is 5-HTTLPR linked to the response of selective serotonin reuptake inhibitors in MDD?
- 2011
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Ingår i: European Archives of Psychiatry and Clinical Neuroscience. - : Springer Science and Business Media LLC. - 0940-1334 .- 1433-8491. ; 261:2, s. 95-102
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Tidskriftsartikel (refereegranskat)abstract
- The role of a functional polymorphism in the transcriptional control region of serotonin transporter gene (5-HTTLPR, SERTPR) has been studied intensively in major depression and in the response to selective serotonin inhibitors (SSRIs) in major depression. The findings have been contradictory, although majority of the studies indicate that the short allele is associated with poor response to SSRIs in major depression. In the present study, we evaluated the association of 5-HTTLPR with treatment response to SSRI medication in Finnish Caucasian MDD patients. A secondary purpose was to study the possible association of this particular polymorphism with major depressive disorder. The aim of the study was to replicate the previous findings in this area. Primary outcomes of the treatment were remission, defined by an exit score of seven or less, and response, defined by a reduction of at least 50% on the MADRS. We had also a control population of 375 healthy blood donors, as a secondary objective was to evaluate the possible association of this particular polymorphism with major depressive disorder. Twenty-nine of the 85 (34.1%) patients reached the remission and 58.8% achieved the predefined response criteria. The l/l genotype of 5-HTTLPR was presented in 51.7% of those patients who achieved remission vs. 25.0% in the non-remitters (P = 0.03). The result remained statistically significant after adjusting for age, gender, medication and MADRS points at the study entry. However, the small sample size limits the reliability of this result.
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| 5. |
- Koivisto, Tero, et al.
(författare)
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Sine wave as a correlating signal for UWB radio
- 2006
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Ingår i: 2006 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS. - NEW YORK, NY : IEEE. - 9780780393899 ; , s. 674-677
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Konferensbidrag (refereegranskat)abstract
- In this paper, an analog correlator for impulse radio is designed using a sine wave as a correlating signal. The design of the low-power sine wave generation circuitry is demonstrated and the analog multiplier using this waveform is implemented. The overall power consumption of the 8GHz LC-VCO and the divider-by-two circuit is 5mW.
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| 6. |
- Malehmir, Alireza, et al.
(författare)
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3D Traveltime Tomography and Reflection Imaging for Mine Planning and Exploration in the Kevitsa Ni-Cu-PGE Mine, Finland
- 2016
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Konferensbidrag (refereegranskat)abstract
- Kevitsa disseminated Ni-Cu-PGE deposit in northern Finland is hosted by a major high velocity (6000-7500 m/s) gabbroic intrusion. The deposit is currently being mined using open-pit mining method at already over 100 m depth, and the final pit will extend to about 400-500 m depth in about 20 years, hence justifying a 3D seismic survey for its careful planning. The 3D seismic survey was carried out in 2010, before mining activities commenced, and resulted in a reflection volume rich in reflectivity, however, poor near the surface likely due to the survey setup and extremely high bedrock velocities. 3D first break tomography was performed with the main objective of linking near-surface geological information with the reflection seismic volume allowing to find a major low-velocity linear zone in the bedrock within the first 50 m depth. This was associated with a gently-dipping reflector with the same strike at 150 m depth and extending to about 500 m depth. The low-velocity zone striking in NE-SW, and originating from a gently-dipping fracture system, may contribute towards the formation of wedge blocks within the northern side of the planned open pit, which can be critical for its stability in the near future.
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| 7. |
- Malehmir, Alireza, 1977-, et al.
(författare)
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Why 3D seismic data are an asset for exploration and mine planning? : Velocity tomography of weakness zones in the Kevitsa Ni-Cu-PGE mine, northern Finland
- 2018
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Ingår i: Geophysics. - : SOC EXPLORATION GEOPHYSICISTS. - 0016-8033 .- 1942-2156. ; 83:2, s. B33-B46
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Tidskriftsartikel (refereegranskat)abstract
- Kevitsa is a disseminated Ni-Cu-PGE (platinum group elements) ore body in northern Finland, hosted by an extremely high-velocity (6.5-8.5 km/s) ultramafic intrusion. It is currently being mined at a depth of approximately 100 m with open-pit mining. The estimated mine life is 20 years, with the final pit reaching a depth of 500-600 m. Based on a series of 2D seismic surveys and given the expected mine life, a high-resolution 3D seismic survey was justified and conducted in the winter of 2010. We evaluate earlier 3D reflection data processing results and complement that by the results of 3D first-arrival traveltime tomography. The combined results provide insights on the nature of some of the reflectors within the intrusion. In particular, a major discontinuity, a weakness zone, is delineated in the tomography results on the northern side of the planned pit. Supported by the reflection data, we estimate the discontinuity, likely a thrust sheet, to extend down approximately 600 m and laterally 1000 m. The weakness zone terminates prominent internal reflectivity of the Kevitsa intrusion, and it is associated with the extent of the economic mineralization. Together with other weakness zones, a couple of which are also revealed by the tomography study, the discontinuity forms a major wedge block that influences the mine bench stability on the northern side of the open pit and likely will cause more issues during the extraction of the ore in this part of the mine. We argue that 3D seismic data should routinely be acquired prior to commencement of mining activities to maximize exploration efficiency at depth and also to optimize mining as it continues toward depth. Three-dimensional seismic data over mineral exploration areas are valuable and can be revisited for different purposes but are difficult to impossible to acquire after mining has commenced.
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| 8. |
- Malehmor, Alireza, et al.
(författare)
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Why 3D seismic data are an asset for both exploration and mine planning? Example of Kevitsa Ni-Cu-PGE, Finland
- 2016
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Ingår i: Lithosphere 2016. - Helsinki, Finland : University of Helsinki, Institute of Seismology. - 9789521050817 ; , s. 83-86
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Konferensbidrag (refereegranskat)abstract
- Kevitsa is a disseminated Ni-Cu-PGE ore body in northern Finland, hosted by an extremely high-velocity (6-8 km/s) mafic-ultramafic intrusion. It is currently being mined at a depth of about 100 m using open-pit mining method. The mine life is expected to be about 20 years, with the final pit depth at around 400-500 m. Based on a series of 2D seismic surveys and given the expected mine life, a high-resolution 3D seismic survey was justified and acquired in winter 2010. Various researchers and teams have exploited these data because of the unique nature of geology, and the data being challenging to interpret but rich in reflectivity. In this study, we present 3D reflection data processing results and complement them with 3D first break tomography work recently carried out. The combined results allow to provide some insights about the nature of some of the reflectors. It for example shows how the tomography results can be used for rock quality studies and further planning of the pit. In particular, we observe a major fracture system, resolved by the tomography results and running in the middle of the planned pit, with the reflection data providing information about its depth extent, estimated to be at least about 500 m. We argue that 3D seismic data should be acquired prior to commencement of mining activities in order to maximize exploration efficiency at depth, but also to optimize mining as it continues towards depth.
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