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- Koubarakis, M., et al.
(författare)
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From copernicus big data to extreme earth analytics
- 2019
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Ingår i: Advances in Database Technology - EDBT. - : OpenProceedings. - 9783893180813 ; , s. 690-693
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Konferensbidrag (refereegranskat)abstract
- Copernicus is the European programme for monitoring the Earth. It consists of a set of systems that collect data from satellites and in-situ sensors, process this data and provide users with reliable and up-to-date information on a range of environmental and security issues. The data and information processed and disseminated puts Copernicus at the forefront of the big data paradigm, giving rise to all relevant challenges, the so-called 5 Vs: volume, velocity, variety, veracity and value. In this short paper, we discuss the challenges of extracting information and knowledge from huge archives of Copernicus data. We propose to achieve this by scale-out distributed deep learning techniques that run on very big clusters offering virtual machines and GPUs. We also discuss the challenges of achieving scalability in the management of the extreme volumes of information and knowledge extracted from Copernicus data. The envisioned scientific and technical work will be carried out in the context of the H2020 project ExtremeEarth which starts in January 2019.
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| 2. |
- Lakiotaki, E, et al.
(författare)
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Potential role of AKT/mTOR signalling proteins in hairy cell leukaemia: association with BRAF/ERK activation and clinical outcome
- 2016
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6, s. 21252-
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Tidskriftsartikel (refereegranskat)abstract
- The potential role of AKT/mTOR signalling proteins and its association with the Raf-MEK-ERK pathway was investigated in hairy cell leukaemia (HCL). BRAFV600E expression and activated forms of AKT, mTOR, ERK1/2, p70S6k and 4E-BP1 were immunohistochemically assessed in 77 BM biopsies of HCL patients and correlated with clinicopathological and BM microvascular characteristics, as well as with c-Caspase-3 levels in hairy cells. Additionally, we tested rapamycin treatment response of BONNA-12 wild-type cells or transfected with BRAFV600E. Most HCL cases expressed p-p70S6K and p-4E-BP1 but not p-mTOR, being accompanied by p-ERK1/2 and p-AKT. AKT/mTOR activation was evident in BONNA-12 cells irrespective of the presence of BRAFV600E mutation and was implicated in cell proliferation enhancement. In multivariate analysis p-AKT/p-mTOR/p-4E-BP1 overexpression was an adverse prognostic factor for time to next treatment conferring earlier relapse. When p-AKT, p-mTOR and p-4E-BP1 were examined separately only p-4E-BP1 remained significant. Our findings indicate that in HCL, critical proteins up- and downstream of mTOR are activated. Moreover, the strong associations with Raf-MEK-ERK signalling imply a possible biologic interaction between these pathways. Most importantly, expression of p-4E-BP1 alone or combined with p-AKT and p-mTOR is of prognostic value in patients with HCL.
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| 3. |
- Ryon, J. E., et al.
(författare)
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Sizes and shapes of young star cluster light profiles in M83
- 2015
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 452:1, s. 525-539
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Tidskriftsartikel (refereegranskat)abstract
- We measure the radii and two-dimensional light profiles of a large sample of young, massive star clusters in M83 using archival HST/Wide Field Camera 3 (WFC3) imaging of seven adjacent fields. We use GALFIT to fit the two-dimensional light profiles of the clusters, from which we find effective (half-light) radii, core radii, and slopes of the power-law (EFF) profile (eta). We find lognormal distributions of effective radius and core radius, with medians of approximate to 2.5 and approximate to 1.3 pc, respectively. Our results provide strong evidence for a characteristic size of young, massive clusters. The average effective radius and core radius increase somewhat with cluster age. Little to no change in effective radius is observed with increasing galactocentric distance, except perhaps for clusters younger than 100 Myr. We find a shallow correlation between effective radius and mass for the full cluster sample, but a stronger correlation is present for clusters 200-300 Myr in age. Finally, the majority of the clusters are best fit by an EFF model with index eta less than or similar to 3.0. There is no strong evidence for change in. with cluster age, mass, or galactocentric distance. Our results suggest that clusters emerge from early evolution with similar radii and are not strongly affected by the tidal field of M83. Mass-loss due to stellar evolution and/or giant molecular cloud interactions appear to dominate cluster expansion in the age range we study.
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