| 1. |
- Kóródi, F., et al.
(författare)
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Fused 1,2,4-TriazoIe Heterocycles. IV. Synthesis of Four New Heterocyclic Ring Systems of [1,2,4]Triazolo[1,3]thiazinoquinolines
- 1997
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Ingår i: Journal of Heterocyclic Chemistry. - : Wiley. - 0022-152X .- 1943-5193. ; 34:4, s. 1275-1281
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Tidskriftsartikel (refereegranskat)abstract
- Syntheses of 5H-[1,2,4]triazolo[5′1′:2,3][1,3]thiazino[5,4-c]quinolines 8, 5H-[1,2,4]triazolo[3′,4′:2,3][1,3]thiazino[5,4-c]quinolines 9, 5H-[1,2,4]triazolo[5′1′:2,3][1,3]thiazino[5,6-c]quinolines 14 and 5H-[1,2,4]triazolo[3′,4′:2,3][1,3]thiazino[5,6-c]quinolines 15 are described starting from 4-chloro-3-chloromethylquinaldine (4) and 1,2,4-triazole-5-thiols 5 taking advantage of different reactivity of the chlorine atoms of 4 under different reaction conditions. The structures of products 8, 9, 14 and 15 and the intermediates leading to them were confirmed by desulfurization, unequivocal syntheses and nmr spectroscopy as well.
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| 2. |
- Kóródi, F., et al.
(författare)
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Fused 1,2,4-triazole heterocycles. I. Synthesis of novel [1,2,4]triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]quinolines
- 1992
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Ingår i: Heterocycles. - : The Japan Institute of Heterocyclic Chemistry. - 0385-5414 .- 1881-0942. ; 34:9, s. 1711-1720
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Tidskriftsartikel (refereegranskat)abstract
- Derivatives of a new heterocyclic ring system of [1,2,4]triazolo[5′,1′: 2,3][1,3]thiazino[6,5-b]quinolines (4,5,6,7 and 8) have been synthesised by the reaction of 2-chloroquinoline-3-carbaldehyde derivatives (1 and 2) with 1,2,4-triazole-5-thiols (3), and subsequent transformations of the hydroxy group of 11-hydroxy[1,2,4]triazolo[5′,1′: 2,3][1,3]thiazino[6,5-b]quinoline (4a).
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| 3. |
- Kóródi, F., et al.
(författare)
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Fused 1,2,4-triazole heterocycles. iii. syntheses and structures of novel [1,2,4]triazolo[1,3]thiazinoquinolines
- 1995
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Ingår i: Heterocyclic Communications. - : Walter de Gruyter GmbH. - 0793-0283 .- 2191-0197. ; 1:4, s. 297-306
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Tidskriftsartikel (refereegranskat)abstract
- Synthetic methods are described for the preparation of 5H-[1,2,4]triazolo[5‘,1’:2,3][1,3]thiazino[4,5-b]quinolines 5, 5H-[1,2,4]triazolo[3',4’:2,3][1,3]thiazino[4,5-b]quinolines 6, 11 H-[1,2,4]triazolo[5‘, 1 ':2,3][1,3]thiazino[6,5-b]quinoline 13 and 11H-[1,2,4]triazolot[3',4’:2,3][1,3]thiazino[6,5-b]quinoline 14 starting from 2-chloro-3-chloromethylquinoline 1 and 1,2,4-triazole-5-thiols 2. Different reactivity of the chlorine atoms of 1 under different reaction conditions, and a new rearrangement were observed during elaboration of these methods. The structures of the products 5, 6,13,14 and the intermediates leading to them were confirmed by desulfurisation reactions, unequivocal syntheses and nmr spectroscopy.
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| 4. |
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| 5. |
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| 6. |
- Korodi, Zoltan
(författare)
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Seroepidemiology of sexually transmitted infections of prostate cancer
- 2008
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: There has been substantial progress in epidemiological research on prostate cancer over the last decade. An area of increasing interest is the possible role of sexual activity and history of sexually transmitted infections as a risk factor for prostate cancer. Specific sexually transmitted infections have only inconsistently been associated with prostate cancer, with positive associations being reported with syphilis, gonorrhea and Human Papillomavirus (HPV) infection. Some studies have also reported detection of viral DNA in prostate cancer cells, although other studies have not reproduced these findings. Seroepidemiological studies offer an attractive alternative for investigation associations of infections with prostate cancer, as they allow i) a readily standardized measure of long-term viral exposure on a biological sample ii) are objective (i.e. independent of subjective reporting) and iii) allow study designs that are epidemiologically valid in terms of sufficient study size and adequate controls. Aims: A large-scale epidemiological evaluation of possible associations between prostate cancer and infection with HPV-6, HPV-11, HPV-16, HPV-18 and HPV-52, Herpes simplex virus 2 (HSV-2) and Human Herpesvirus 8 (HHV-8) as well as two common human polyomaviruses (BK and JC). Results: Paper I is based on a follow-up of up to 24 years of the serum biobank of the Finnish Social Insurance agency, that identified 165 cases of prospectively occurring prostate cancer cases and matched controls that did not develop cancer during a similar length of follow-up. The seroprevalence of STIs was low in this cohort (2,4% for HHV-8 and 6,9% for HSV-2) and were not associated with prostate cancer risk (OR for prostate cancer if HHV-8-positive 0.74 (95% CI, 0.19–2.88), if HSV-2-positive 0.93 (95% CI, 0.44–1.96). In paper II, we used the biobanks that collaborate in the Nordic Biological Specimen Biobank Working Group on Cancer, Causes and Control that have jointly enrolled more than 200,000 men. Registry linkages identified 799 prospectively occurring cases of cancer and a selection of 2596 matched controls that did not develop prostate cancer. Seroprevalences for HPV-16, -18 or -33 were not significantly associated with prostate cancer risk, neither in the joint cohort nor in any one of the collaborating biobanks in the network. In paper III, we developed a multiplexed serology system for simultaneous one-tube detection of antibodies to several STIs (sexually transmitted infections) and applied it to a population-based case-control study of 245 men with prostate cancer and 204 matched controls. Seropositivities against HPV-6, -16, -18 and -52, HSV-2 or HHV-8 were not associated with prostate cancer. On the contrary, presence of multiple STIs was actually less common among prostate cancer patients (OR 0.18: 95% CI 0.04-0.83). In paper IV, we applied our multiplexed serology system to an even larger population-based case-control study of 2953 men with prostate cancer and 1819 population-based controls. The only infection that was significantly associated with prostate cancer was HHV-8, an inverse association (OR: 0,67; 95% Confidence Interval (CI): 0,51- 0,87). Conclusion: Technical development in high-throughput serology (“serolomics”) enabled sufficiently large-scale epidemiological studies to evaluate the STI hypothesis in prostate carcinogenesis. However, our studies which where of large size and had fairly strong statistical power, showed that it is unlikely, that there would exist any positive associations of STIs and prostate cancer.
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| 7. |
- Okroj, Marcin, et al.
(författare)
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Antibodies against Kaposi sarcoma-associated herpes virus (KSHV) complement control protein (KCP) in infected individuals
- 2007
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Ingår i: Vaccine. - : Elsevier BV. - 1873-2518 .- 0264-410X. ; 25:48, s. 8102-8109
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Tidskriftsartikel (refereegranskat)abstract
- Kaposi sarcoma-associated herpesvirus (KSHV) is the most important etiopathological factor of Kaposi's sarcoma (KS) and some specific types of malignant lymphomas. One of the viral lytic genes encodes the KSHV complement control protein (KCP), which functionally mimics human complement inhibitors. Although this protein provides an advantage for evading the complement attack, it can serve as target for adaptive immune response. Herein, we identified anti-KCP IgG antibodies in patients with KS and KSHV-related lymphomas. KCP-specific antibodies were only detected in sera of those patients who had high titres of antibodies against lytic or latent KSHV antigens. Complement control protein domain 2 (CCP2) was found to be the most immunogenic part of the KCP protein. Furthermore, pre-incubation of KCP-expressing CHO cells with patient sera containing anti-KCP antibodies resulted in an increased complement deposition when incubated with human serum.
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| 8. |
- Szabo, Zoltan, Associate professor, et al.
(författare)
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1H and 13C NMR study of novel fused 1,2,4‐triazole heterocycles
- 1992
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Ingår i: Magnetic Resonance in Chemistry. - : Wiley. - 0749-1581 .- 1097-458X. ; 30:11, s. 1111-1116
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Tidskriftsartikel (refereegranskat)abstract
- The 1H and 13C NMR spectra of some novel 1,2,4‐triazolo [1,3] thiazinoquinoline isomeric pairs are interpreted in terms of structural assignments. The structure of most compounds has been confirmed by NOE difference spectroscopy. Characteristic differences have been observed in both 1H and 13C NMR spectra of these isomeric Pairs: some of the 1H and 13C chemical shifts, and also the one bond 13C1H couplings of triazole protons, differ consistently in the NMR spectra of the isomers. The coupling constants have been determined using a combination of INEPT and chemical shift selective filtering.
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