| 1. |
- Harjula, Erkki, et al.
(författare)
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Energy-aware load monitoring for improving battery life of mobile peer-to-peer nodes
- 2016
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Ingår i: SUSTAINABLE COMPUTING-INFORMATICS and SYSTEMS. - : ELSEVIER SCIENCE BV. - 2210-5379. ; 12, s. 43-54
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Tidskriftsartikel (refereegranskat)abstract
- In this article, we propose an energy -aware load monitoring model, called e-Mon, for enabling energy aware load balancing in Peer-to-Peer (P2P) systems. P2P is a scalable and self-organizing technology for utilizing computational resources of the end-user devices for the benefit of a computing system. In P2P systems, the need for fair balance of load is crucial since the end-users need to be incentivized to participate in the system. The short battery life, caused by additional strain on the computational resources of the end-user devices, is a significant negative incentive factor for mobile end-users of current P2P systems. The e-Mon model, proposed in this article, enables moving load from energy-critical to less energy-critical nodes in P2P systems. This is done by including the energy status of a peer node as one of the factors defining a nodes load. The model helps saving the energy of mobile P2P nodes, particularly in cases when the remaining battery capacity is low. The article provides a thorough energy efficiency evaluation demonstrating that e-Mon can significantly improve the battery life of mobile nodes by improving the quality and fairness of load balance between heterogeneous nodes. With a proper selection of a load balancing model for the application scenario, e-Mon is shown to achieve up to 470% battery life extension compared to the case with traditional load balancing with no battery monitoring. (C) 2016 Elsevier Inc. All rights reserved.
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| 2. |
- Hallberg, Per, et al.
(författare)
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Underestimation of intraocular pressure after photorefractive keratectomy : a biomechanical analysis
- 2006
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Ingår i: Medical and Biological Engineering and Computing. - : Springer. - 0140-0118 .- 1741-0444. ; 44, s. 609-618
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Tidskriftsartikel (refereegranskat)abstract
- Excimer laser surgery, to correct corneal refraction, induces changes in corneal thickness and curvature. Both factors can cause measurement errors when determining intraocular pressure (IOP). This study evaluates effects of photorefractive keratectomy (PRK) on IOP measurements, using Goldmann applanation tonometry (GAT) and Applanation resonance tonometry (ART), in an in vitro model. Six porcine eyes was enucleated and pressurised to a constant IOP = 30 mmHg. After removal of the epithelium, the eyes were PRK-treated for a total of 25 dioptres. The measured IOP decreased 13.2 mmHg for GAT and 9.0 mmHg for ART. The total underestimation by GAT was larger than for ART, and a part of the ART underestimation (3.5 mmHg) was assigned to sensitivity to the change in corneal surface structure resulting from the removal of epithelium. The flat contact probe of GAT, as compared with the convex tip of ART, provided explanation for the difference in IOP measurement error after PRK.
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| 3. |
- Hellinen, Laura, et al.
(författare)
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Inhibition of prolyl oligopeptidase : A promising pathway to prevent the progression of age-related macular degeneration
- 2022
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Ingår i: Biomedicine and Pharmacotherapy. - : Elsevier. - 0753-3322 .- 1950-6007. ; 146
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Tidskriftsartikel (refereegranskat)abstract
- Dry age-related macular degeneration (AMD) is a currently untreatable vision threatening disease. Impaired proteasomal clearance and autophagy in the retinal pigment epithelium (RPE) and subsequent photoreceptor damage are connected with dry AMD, but detailed pathophysiology is still unclear. In this paper, we discover inhibition of cytosolic protease, prolyl oligopeptidase (PREP), as a potential pathway to treat dry AMD. We showed that PREP inhibitor exposure induced autophagy in the RPE cells, shown by increased LC3-II levels and decreased p62 levels. PREP inhibitor treatment increased total levels of autophagic vacuoles in the RPE cells. Global proteomics was used to examine the phenotype of a commonly used cell model displaying AMD characteristics, oxidative stress and altered protein metabolism, in vitro. These RPE cells displayed induced protein aggregation and clear alterations in macromolecule metabolism, confirming the relevance of the cell model. Differences in intracellular target engagement of PREP inhibitors were observed with cellular thermal shift assay (CETSA). These differences were explained by intracellular drug exposure (the unbound cellular partition coefficient, Kpuu). Importantly, our data is in line with previous observations regarding the discrepancy between PREP's cleaving activity and outcomes in autophagy. This highlights the need to further explore PREP's role in autophagy so that more effective compounds can be designed to battle diseases in which autophagy induction is needed. The present work is the first report investigating the PREP pathway in the RPE and we predict that the PREP inhibitors can be further optimized for treatment of dry AMD.
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| 4. |
- Johannesson, Gauti, et al.
(författare)
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Change in intraocular pressure measurement 2 years after myopic laser-assisted subepithelial keratectomy
- 2012
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Ingår i: Journal of cataract and refractive surgery. - : Ovid Technologies (Wolters Kluwer Health). - 0886-3350 .- 1873-4502. ; 38:9, s. 1637-1642
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To evaluate intraocular pressure (IOP) measurements 24 months after laser-assisted subepithelial keratectomy (LASEK) with 3 tonometry methods-Goldmann applanation tonometry (DCT), Pascal dynamic contour tonometry (DCT), and applanation resonance tonometry (ART)-and to compare them with measurements taken preoperatively and 3 and 6 months postoperatively. SETTING: Department of Ophthalmology, Umea University, lima Sweden. DESIGN: Prospective randomized single-center. METHODS: One randomized eye per person from myopic healthy individuals who had LASEK was included. Visual acuity, central corneal thickness (CCT), corneal curvature, and IOP were measured at all time points. Six IOP measurements were performed per method, with a 5-minute lapse between methods. RESULTS: The study evaluated 38 eyes. Two years after LASEK, dynamic ART was the only method that did not measure significantly lower IOP than before LASEK (mean -0.2 mm Hg +/- 1.6 [SD]). The greatest difference was with GAT (mean -1.9 +/- 1.7 mm Hg) followed by static ART (mean -1.2 +/- 1.6 mm Hg) and then DCT (mean -0.9 +/- 1.3 mm Hg). All methods measured significantly lower IOP at 3 months and 6 months. CONCLUSIONS: Dynamic ART, which analyses IOP measurement during indentation, showed no significant difference in measured IOP after 24 months. The convex tip of the ART device and the continuous sampling of data during corneal indentation seem to be factors in why dynamic ART was less affected by corneal properties and therefore more suitable for IOP measurement in LASEK-treated eyes, although this must be confirmed in larger trials.
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| 5. |
- Jóhannesson, Gauti, et al.
(författare)
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Change in intraocular pressure measurement after myopic LASEK : a study evaluating Goldmann, Pascal and applanation resonance tonometry
- 2012
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Ingår i: Journal of glaucoma. - : Lippincott Williams & Wilkins. - 1057-0829 .- 1536-481X. ; 21:4, s. 255-259
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To prospectively evaluate 3 tonometry methods—the gold standard, Goldmann applanation tonometry, a new method, Pascal dynamic contour tonometry (PDCT), and a method under development, applanation resonance tonometry (ART)—with respect to intraocular pressure (IOP) measurements before, 3 and 6 months after laser-assisted subepithelial keratectomy (LASEK).Materials and Methods: One randomly assigned eye of each of 53 healthy individuals, who underwent LASEK surgery for myopia was studied. Visual acuity, central corneal thickness, corneal curvature, and IOP were measured at each visit. Six IOP measurements/methods with 5 minutes pause between methods were performed.Results: All tonometry methods measured a significantly lower IOP after LASEK correction by a mean of −3.1 diopters. The IOP reduction was largest after 6 months for Goldmann applanation tonometry (−1.7±1.8 mm Hg) followed by ARTstat (−1.2±1.5 mm Hg), PDCT (−1.1±1.6 mm Hg), and ARTdyn (−1.0±1.5 mm Hg). The reduction of IOP did not differ significantly between different methods (P=0.11). There was a significant further reduction of measured IOP for PDCT between 3 and 6 months (−0.5±1.0 mm Hg). Uncorrected visual acuity improved significantly between 3 and 6 months postoperatively from 1.32±0.28 to 1.43±0.27.Conclusions: All tonometry methods measured a significant, but low, reduction of IOP 3 and 6 months after LASEK. Further change in visual acuity and IOP measurements between 3 and 6 months suggest a still ongoing postoperative process.
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| 6. |
- Jonsson, Frida, et al.
(författare)
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Mutations in Collagen, Type XVII, Alpha 1 (COL17A1) Cause Epithelial Recurrent Erosion Dystrophy (ERED)
- 2015
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Ingår i: Human Mutation. - : John Wiley & Sons. - 1059-7794 .- 1098-1004. ; 36:4, s. 463-473
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Tidskriftsartikel (refereegranskat)abstract
- Corneal dystrophies are a clinically and genetically heterogeneous group of inherited disorders that bilaterally affect corneal transparency. They are defined according to the corneal layer affected and by their genetic cause. In this study, we identified a dominantly inherited epithelial recurrent erosion dystrophy (ERED)-like disease that is common in northern Sweden. Whole-exome sequencing resulted in the identification of a novel mutation, c.2816C>T, p.T939I, in the COL17A1 gene, which encodes collagen type XVII alpha 1. The variant segregated with disease in a genealogically expanded pedigree dating back 200 years. We also investigated a unique COL17A1 synonymous variant, c.3156C>T, identified in a previously reported unrelated dominant ERED-like family linked to a locus on chromosome 10q23-q24 encompassing COL17A1. We show that this variant introduces a cryptic donor site resulting in aberrant pre-mRNA splicing and is highly likely to be pathogenic. Bi-allelic COL17A1 mutations have previously been associated with a recessive skin disorder, junctional epidermolysis bullosa, with recurrent corneal erosions being reported in some cases. Our findings implicate presumed gain-of-function COL17A1 mutations causing dominantly inherited ERED and improve understanding of the underlying pathology.
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| 7. |
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| 8. |
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| 9. |
- Lindahl, Olof, et al.
(författare)
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Ögontrycksmätning på laserbehandlade hornhinnor
- 2004
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Ingår i: Svenska läkaresällskapets riksstämma 24-26 november 2004. - Stockholm : Svenska läkaresällskapet. ; , s. F15-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Lundqvist, Oskar, et al.
(författare)
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A paired comparison of intracameral mydriatics in refractive lens exchange surgery
- 2014
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Ingår i: Acta Ophthalmologica. - : Wiley. - 1755-375X .- 1755-3768. ; 92:5, s. 482-485
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To compare the efficacy and intra-operative safety of intracameral mydriatics to topical mydriatics in patients undergoing refractive lens exchange (RLE) surgery. Methods: In a randomized intra-individually comparing study performed at Koskelas Eye Clinic, Lulea, and Department of Clinical Sciences/Ophthalmology, Umea University Hospital, Umea, Sweden, 56 patients undergoing same-day bilateral RLE were included. Pupils were randomly dilated with topical mydriatics in one eye and intracameral mydriatics in the fellow eye. Pupil sizes were recorded intra-operatively throughout the procedures. Perceived pain/discomfort and glare were assessed immediately postoperatively using a visual analogue scale from 0 to 10. Results: Topical mydriatics and intracameral mydriatics both give satisfactory pupil dilation in routine RLE. However, there was noticeable iris billowing in 17 eyes dilated with topical mydriatics but only one eye with intracameral mydriatics (p < 0.001). Pupils were initially slightly larger in the topical mydriatics group but contracted during surgery. There was no perceived difference with regards to glare, pain or discomfort between the treatments. The surgeon graded intracameral mydriatics eyes as easier to operate on. Conclusion: Both topical mydriatics and intracameral mydriatics give satisfactory mydriasis for RLE, but pupil constriction and iris billowing are more pronounced with topical mydriatics.
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